Aristotle Funds, an investment advisor, released its “Growth Equity Fund” fourth-quarter 2025 investor letter. A copy of the letter can be downloaded here. U.S. equity markets reached new all-time highs in Q4 2025, with the S&P 500 Index rising 2.66% and the Bloomberg U.S. Aggregate Bond Index increasing by 1.10%. Within the Russell 1000 Growth Index, healthcare, communication services, and financials were the top-performing sectors, while utilities, real estate, and materials lagged. The U.S. economy show ...

BOCA RATON, Fla., Feb. 18, 2026 (GLOBE NEWSWIRE) -- LIXTE Biotechnology Holdings, Inc. (“LIXTE” or the “Company”) (Nasdaq: LIXT), a clinical stage pharmaceutical and med-tech company focused on advancing cancer treatments, today announced it has appointed Sidney Braun as Chief Executive Officer of the Company’s Liora Technologies Europe Ltd. subsidiary (“Liora”). A veteran of the healthcare industry, Braun brings to Liora more than two decades of operational and strategic advisory experience at companies in ...

Core Insights - Exelixis, Inc. (EXEL) reported better-than-expected fourth-quarter results for 2025, with adjusted earnings per share (EPS) of 94 cents, surpassing the Zacks Consensus Estimate of 77 cents and up from 55 cents in the same quarter last year [1][2][6] - The company achieved net revenues of $598.7 million, exceeding the Zacks Consensus Estimate of $585 million, representing a year-over-year increase of 5.6% [2][4] - Despite the positive results, Exelixis' stock experienced a decline in pre-market trading following the earnings announcement [2] Financial Performance - The growth in net revenues was primarily driven by higher product sales, with net product revenues reaching $546.6 million, a 6% increase year over year [4] - Cabometyx (cabozantinib) generated revenues of $544.7 million, slightly missing the Zacks Consensus Estimate of $554 million but marginally exceeding internal estimates [5][6] - Collaboration revenues totaled $52.1 million, reflecting a 1% year-over-year increase, mainly due to higher royalty revenues from cabozantinib sales outside the U.S. [8] Operating Expenses - Research and development expenses, including stock-based compensation, decreased by 14.4% year over year to $213.2 million, attributed to lower clinical trial costs [9] - Selling, general, and administrative expenses fell by 8% year over year to $123 million, primarily due to reductions in stock-based compensation and personnel costs [9] Share Repurchase Program - During the quarter, Exelixis repurchased $264.5 million in shares, completing a $500 million share repurchase program authorized in February 2025 [10] - Since the initiation of its first share repurchase program in March 2023, the company has repurchased a total of $2.16 billion in common stock [10] 2025 Results and 2026 Guidance - For 2025, Exelixis reported revenues of approximately $2.32 billion, a 7% increase from 2024, with adjusted EPS of $3.08, up from $2 in 2024 [11] - The company expects total revenues for 2026 to be between $2.525 billion and $2.625 billion, with net product revenues projected to be in the range of $2.325 billion to $2.425 billion [12] Pipeline and Regulatory Updates - Exelixis is developing zanzalintinib, a next-generation oral investigational tyrosine kinase inhibitor, with an NDA accepted by the FDA for previously treated metastatic colorectal cancer [14][15] - The company is also advancing several phase I assets and has two new investigational new drug filings planned for 2026 [21][22] Market Position and Future Outlook - Cabometyx remains a leading TKI monotherapy for renal cell carcinoma (RCC) and is gaining traction in the neuroendocrine tumor market [23] - The strong uptake of Cabometyx in the newly approved NET indication is expected to drive future sales growth [24] - The potential approval of zanzalintinib is viewed as a significant catalyst for Exelixis' oncology pipeline, with management expanding sales infrastructure to support growth [24][25]

Eli Lilly is paying $350 million upfront to collaborate with Chinese biotech Innovent in developing new treatments for cancer and immune disorders, a further vote of confidence for the innovation capabilities of the country’s drugmakers https://t.co/SViSaZ5qnn ...

Fears flight route changes could affect cancer patients https://t.co/9R1gAwMoHB ...

Core Insights - AngioDynamics (ANGO) is experiencing growth driven by its NanoKnife product and a focus on cancer treatment markets, supported by a strong second-quarter fiscal 2026 performance and ongoing studies [1][2] Financial Performance - AngioDynamics reported a revenue increase of 8.8% year over year to $79.4 million in fiscal Q2 2026, with the NanoKnife revenue rising 22.2% due to record prostate cancer procedure volumes [7][10] - The Auryon franchise generated $16.3 million in revenue, reflecting an 18.6% year-over-year growth, marking 18 consecutive quarters of double-digit growth [5][10] - The company has a market capitalization of $422.1 million and projects a 51.9% growth over the next year [2] Growth Drivers - The NanoKnife franchise is a key growth driver, with probe sales increasing 14.4% year over year, attributed to rising adoption in prostate cancer procedures [3][4] - Management noted steady adoption of NanoKnife, supported by procedural growth and increasing clinical utilization, particularly in the prostate cancer market [4] - The mechanical thrombectomy portfolio saw a revenue increase of 3.9% year over year to $11 million, with AlphaVac achieving over 40% growth [9] Market Position and Trends - AngioDynamics has gained 9.8% in share price over the last six months, outperforming the industry growth of 5.2% and the S&P 500's increase of 11.9% [1] - The company has been experiencing a positive estimate revision trend, with the Zacks Consensus Estimate for loss narrowing to 27 cents per share for fiscal 2026 [13] Challenges - Management acknowledged ongoing tariff-related costs of $4–$6 million for the fiscal year, which may pose a structural margin headwind [11][12]

व्हेनएवर आई सॉ अ कंट्री ग्रोइंग अप स्पेशली आवर नेबर कंट्री लॉन्चिंग सम रॉकेट और सम सेटेलाइट इंटू द स्पेस आई वुड नोटिस जनरली टू काइंड्स ऑफ ग्रुप्स इन द पाकिस्तानी यूथ। द फर्स्ट व्हिच जस्ट टॉक्स या पाकिस्तान हैज़ बीन फॉलिंग बिहाइंड इन द स्पेस रिसर्च यस वी आर नॉट डूइंग इनफ बट व्हाट कैन वी डू एंड देन देयर इज़ द सेकंड ग्रुप व्हिच एक्चुअली ट्राइ टू कंट्रीब्यूट इन व्हाटएवर कैपेसिटी दे कैन एंड इफ यू हेड आस्क मी अ डेकेड एगो देयर फातिमा व्हाट डू यू वांट टू बी व्हेन यू ग्रो अप ओर व्हाट डू यू वांट टू डू विथ योर लाइफ आई आ ...

Core Insights - Hoth Therapeutics, Inc. announced positive interim results from the CLEER-001 clinical trial, demonstrating significant improvements in disease severity and patient-reported symptoms for cancer patients receiving EGFR inhibitor therapy [1][2][6]. Group 1: Primary Endpoint Results - The primary endpoint, assessed using the ARIGA scale, showed a ~50% reduction in disease severity, with mean ARIGA scores improving from 1.67 at baseline to 0.83 by Week 6 [3][4]. - All evaluable patients achieved ARIGA 1 by Week 6, indicating they fell within the low-severity disease range, with improvements noted as early as Week 3 [4]. Group 2: Additional Endpoints - The trial also reported a ~34% improvement in oncology toxicity (CTCAE), with scores decreasing from 2.0 at baseline to 1.33 at Week 6 [7]. - Patient-reported pruritus scores improved by ~37%, from a mean of 4.22 at baseline to 2.67 at Week 6, indicating a significant reduction in symptom severity [7]. Group 3: Treatment Context and Implications - EGFR inhibitors are critical in treating various cancers, but they often lead to treatment-related toxicity that can hinder patient outcomes [6]. - The results from CLEER-001 suggest that HT-001 could play a vital role in supportive care, helping patients maintain their cancer treatment regimens [6][8]. Group 4: Company Overview - Hoth Therapeutics is a clinical-stage biopharmaceutical company focused on developing innovative therapies aimed at improving the quality of life for cancer patients [9].

Core Insights - AbbVie and Genmab announced topline results from the Phase 3 EPCORE DLBCL-1 trial, showing that epcoritamab improved progression-free survival (PFS) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) compared to standard chemoimmunotherapy [2][3] Group 1: Trial Results - The EPCORE DLBCL-1 trial demonstrated a PFS improvement with a hazard ratio (HR) of 0.74 (95% CI 0.60 to 0.92), indicating a statistically significant benefit [2][3] - Improvements were also noted in complete response rates (CRR), duration of response (DoR), and time to next treatment for patients receiving epcoritamab [2] - However, the trial did not show a statistically significant improvement in overall survival (OS) with an HR of 0.96 (95% CI 0.77 to 1.20) [2] Group 2: Study Details - The trial enrolled 483 patients with R/R DLBCL, with 73% having received two or more prior lines of therapy, and all patients were ineligible for high-dose chemotherapy and autologous stem cell transplant [3] - EPCORE DLBCL-1 is the first Phase 3 study to show PFS improvement using a CD3xCD20 T-cell engaging bispecific monotherapy [3] Group 3: Safety and Regulatory Actions - Adverse events observed were consistent with the known safety profile of epcoritamab, and the companies are assessing the impact of external factors such as the COVID-19 pandemic on trial outcomes [4] - AbbVie and Genmab plan to engage global regulatory authorities to discuss next steps following the trial results [4] Group 4: Background on DLBCL - DLBCL accounts for approximately 25-30% of all non-Hodgkin lymphoma (NHL) cases, with around 25,000 new cases diagnosed annually in the U.S. [5] - This type of lymphoma is fast-growing and primarily affects B-cell lymphocytes, with management remaining challenging despite new therapies [5] Group 5: Epcoritamab Overview - Epcoritamab, known as EPKINLY in the U.S. and Japan, and TEPKINLY in the EU, has received regulatory approval in over 65 countries for certain lymphoma indications [6][9] - The drug is being evaluated in ongoing clinical programs as both a monotherapy and in combination regimens across various hematologic malignancies [6][10]

Evorpacept Program - ALX Oncology's Evorpacept is a leading CD47 program with a unique design and inactive Fc region, showing activity in five combinations and targeting a CD47 biomarker[8] - In HER2+ Gastric Cancer, the Overall Response Rate (ORR) increased from 26% with Trastuzumab + Ramucirumab + Paclitaxel to 65% with Evorpacept + Trastuzumab + Ramucirumab + Paclitaxel in the ASPEN-06 subset, a randomized Phase 2 trial[31] - In HER2+ Breast Cancer, the ORR was 56% with Evorpacept + Zanidatamab compared to a benchmark of 22% with Margenza® + Chemo[32] - In indolent NHL, the complete response rate improved from a Rituximab benchmark of 18% to 54% with Evorpacept + Rituximab[35] - The addition of Evorpacept reduced the risk of disease progression or death by 61% for patients with retained HER2+ disease and high CD47 expression (Hazard Ratio = 0.39)[46] - The addition of Evorpacept led to improved overall survival for patients with retained HER2+ and high CD47 expression (Hazard Ratio = 0.63)[49] - Approximately 20,000 addressable patients are CD47-high in 2L+ HER2+ Breast Cancer, representing a $2-4 billion market opportunity[73] ALX2004 Program - ALX2004 is a highly differentiated EGFR ADC in Phase 1 dose escalation, targeting EGFR-expressing tumors including NSCLC, CRC, HNSCC, and ESCC, with initial safety data anticipated in 1H 2026[8, 99] - Preclinical data supports dose-dependent activity and a differentiated safety profile for ALX2004, with no evidence of payload-related ILD in NHP toxicity studies[8, 82] - ALX Oncology's projected cash runway extends into Q1 2027, driving key milestones for both Evorpacept and ALX2004 programs[10, 105]