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AI驱动的药物发现引擎 - Isomorphic Labs 正在构建一个药物设计引擎，旨在为不同疾病领域和适应症设计新的分子，甚至适用于不同的药物形式[2] - 该引擎由一系列AI模型驱动，需要大约六个类似AlphaFold的突破性技术共同作用[3] - 这些模型包括预测蛋白质结构、分子结合强度以及药物安全性和吸收性的能力[3][6] 传统药物发现的变革 - 传统药物设计是迭代的，耗时且成本高昂，而Isomorphic Labs 正在将这一过程转移到虚拟世界，在计算机上进行设计和测试，从而缩短时间并提高效率[8][9][10] - 通过在计算机上进行多次迭代，选择最佳结果进行实验室测试，从而跳过步骤，更快地获得更好的结果[10] 模型能力与挑战 - AlphaFold 已经解决了蛋白质折叠问题，但仍需要提高模型的准确性，并理解分子如何与身体的不同部分相互作用[11][12][13] - 分子空间巨大（约10的60次方），需要生成模型和搜索过程来有效地搜索整个空间，从而减少需要实验室测试的分子数量[15][16] 数据策略与质量 - 机器学习依赖于高质量的数据，Isomorphic Labs 拥有全面的数据战略，利用公共数据、历史数据以及专门为机器学习模型创建的湿实验室数据[24][25] - 公司在理解、摄取、清理数据以及从中提取信号方面投入了大量精力[26] 通用性与可重用性 - Isomorphic Labs 专注于构建通用的技术，可以应用于任何靶点、任何疾病领域，甚至任何不同的药物形式[27][28] - 通用模型更具挑战性，但可以创造针对长期未解决的问题的全新化学物质[30][31] 疾病领域重点 - 公司专注于免疫学和肿瘤学，因为这些领域的临床试验更易于处理，可以在更短的时间内完成，并且对患者的影响很大[33][34] - 目标是将癌症转变为一种慢性疾病，患者可以通过药物治疗获得正常的寿命，这可能在几年内实现[36][37] 模型能力与应用 - 这些模型可以应用于整个人类蛋白质组，并且由于神经网络模型运行速度快，可以并行分析数千个蛋白质[39] - 这改变了实验设计，因为在实验世界中，一次只能研究一个蛋白质[40] 合作与里程碑 - 与诺华和礼来等公司的合作非常密切，在一些具有挑战性的靶点上取得了良好的进展[44] - 在某些情况下，已经识别出与以前未知的蛋白质结合的首批化学物质[45] 未来展望 - 目标是在2-3年内将AI药物发现过程缩短至几个月，关键在于提高计算机实验结果的预测准确性[47][48][49] - 展望未来，AI工具可以帮助诊断疾病，并提供相应的药物治疗，从而对人类健康和疾病产生重大影响[50][51]

Core Message - Life adversities, like cancer, are unwanted gifts that can be returned, exchanged, regifted, or shelved [5][6][9][11][21] - Integrating these unwanted gifts into one's identity can lead to personal growth and resilience [9][22][26] - The experience of adversity can foster compassion, consideration, sensitivity, and caring in individuals [21] Cancer Experience & Impact - A cancer diagnosis evokes terror and enters one into an unimaginable world [3] - The speaker experienced a sense of changing identity and beauty, shame, disfigurement, and devastation after being diagnosed with cancer at 37 [6][7] - The speaker had a breast cancer recurrence seven years after the initial diagnosis and developed skin cancer twice [14] - The speaker's children's conversations shifted from "boooos in her boobies" to life and death discussions during the second cancer experience [19] Coping & Growth - Taking care of oneself can aid in early detection and tolerance of treatments [17] - Resiliency is developed daily by showing up, rewiring neuropathways, and coping with adversity [23] - The speaker chooses not to return, exchange, or regift life, embracing it as a wondrous gift [24] - The speaker emphasizes the importance of grasping onto empowering coping techniques during challenging times [24][25]

Health Impact of 9/11 Toxic Exposure - First responders are battling chronic illnesses due to toxic exposure at disaster sites [1] - Common initial health issues included coughing, asthma, sinus problems, and gastroesophageal reflux disease (GERD), alongside anxiety, PTSD, and depression [7][8] - Over time, chronic conditions like COPD and lung scarring (fibrosis) emerged [8] - Thousands of cancer cases are now being seen, including severe cancers, with early cancers predominantly being blood cancers [9] Program & Funding Needs - Northwell's program provides healthcare to nearly 5,000 first responders, offering annual exams, physicals, blood work, chest X-rays (every other year), breathing tests, and cancer screenings [4][5] - The World Trade Center Health Program monitors and treats individuals affected by 9/11 [12] - There is a need for continued funding to ensure timely and seamless care for affected individuals [11][13] - 9/11-linked cancers have increased by a shocking 143% in the last five years, highlighting the growing need for support [10] Ongoing Suffering - First responders are still getting sick and suffering 24 years later [16] - The 9/11 responder and survivor funding act is currently stalled in Congress [14]

Healthcare Innovation - Russia officially announces cancer vaccine is ready for clinical use [1] - The cancer vaccine will be rolled out to patients for free [1]

Core Argument - The presentation emphasizes the importance of acknowledging both the positive and negative aspects of life to cultivate genuine gratitude [12][17][18][21] - It suggests that recognizing both "story one" (difficulties) and "story two" (blessings) leads to a more complete and realistic perspective ("story three") [12][13][19][20] Psychological and Health Benefits of Gratitude - Research indicates that focusing on positive aspects ("tailwinds") can enhance happiness, optimism, and positive emotions [15] - Medical studies suggest gratitude can calm the nervous system, boost immunity and heart health, improve sleep, and strengthen relationships [16] - Psychologists advise practicing gratitude with discernment, ensuring it is realistic and honest [17] Personal Anecdotes - The presentation includes personal stories of hardship, including family illness, loss, and personal health challenges [1][2][3][4][5][6] - It also shares stories of positive experiences, such as a loving family, successful career, and travel [7][8][9][10][11] - The speaker highlights a 35-year teaching career and achieving a PhD after surviving stage four cancer [10] Practical Application - The presentation advocates for a mindset of deep thankfulness for all of life, rather than simply keeping a gratitude journal [20] - It suggests that cultivating gratitude can help individuals embrace both the difficult and the fabulous aspects of their lives [21]

New research suggests cells with faulty DNA can be prevented from growing into full-blown tumours through the activity of healthy cells around them. That could prove an effective strategy for stopping cancer https://t.co/onS8jqg5Cv ...

New findings about cancer are forcing clinicians to rethink their approach to preventing the disease https://t.co/KTZp1IxqH1 ...

Health Benefits of Fasting - Fasting is presented as a highly effective treatment for high blood pressure, a leading cause of death and disability [1] - Fasting can reduce insulin resistance and enhance cognitive capacities, potentially affecting depression and anxiety [1] - Fasting mobilizes visceral fat, which is linked to heart disease, cancer, and diabetes [2] - Chemical changes that happen with exercise also occur with fasting, such as increasing EDNF, a neurochemical protecting the brain from Alzheimer's disease [3][4] Societal and Lifestyle Context - The report highlights that 76% of people are overweight or obese, indicating a significant public health challenge [3] - The current environment is designed to promote unhealthy lifestyles, making people fat, sick, and miserable [3] Unique Selling Points of Fasting - Fasting is presented as a unique intervention with benefits beyond weight loss [5] - All human beings have the capacity to fast [4] - Water fasting has shown profound effects on conditions unresolved by medications, including polycystic ovarian syndrome [4]

Philanthropy - Phil Knight donates $2 billion to cancer research [1]