Financial Data and Key Metrics Changes - The first quarter results showed a 4% constant currency revenue decline year-over-year, primarily due to the loss of exclusivity of Atozed in Europe [20] - Adjusted gross margin was 61.7%, down from 62.1% in the same quarter last year, reflecting unfavorable pricing impacts [25] - Adjusted EBITDA margin for the first quarter was 32%, about 150 basis points better than expected [26] - Free cash flow before one-time costs was $146 million, an improvement from the prior year [27] Business Line Data and Key Metrics Changes - The women's health franchise grew 12% excluding exchange, driven by Nexplanon, which was up 14% [10] - Fertility products experienced nearly 26% global growth, with U.S. sales increasing by 70% [12] - Jada grew 20% in the quarter, with significant adoption among major birthing hospitals [13] - Biosimilars showed mixed results, with HEDLEMA growing 57% while Ontrazont and REMFLEXIS continued to decline [14] Market Data and Key Metrics Changes - Approximately 75% of revenue is generated outside the U.S., with Europe and Canada contributing about 25% and China about 13% [7] - The U.S. market is primarily supplied by European manufacturing, with limited exposure to tariffs in 2025 [6][9] Company Strategy and Development Direction - The company is focusing on deleveraging, aiming for a net leverage ratio below four by year-end 2025 [5][30] - A strategic shift has been made to redirect dividend funds towards debt reduction, allowing for nearly $200 million in potential savings [5] - The company plans to pursue business development opportunities while maintaining lower leverage [6] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in achieving revenue targets for VITAMA, citing strong market signals and positive feedback from healthcare providers [43] - The macroeconomic environment remains uncertain, but the company has limited exposure to current tariff policies [6][66] - Future growth is expected to be driven by the successful launch of new products and ongoing operational efficiency improvements [39] Other Important Information - The company anticipates $200 million in annual savings from restructuring initiatives [5] - Onetime costs related to the spin-off are expected to be zero in 2025, with a focus on improving operating expense efficiency [27][28] Q&A Session Summary Question: Confidence in VITAMA sales target and access issues - Management is confident in reaching the $150 million sales target for VITAMA due to strong market uptake and effective managed care strategies [43] Question: Priorities regarding deleveraging and business development - The focus is currently on deleveraging, with future opportunities for business development as leverage decreases [46] Question: Future business development deal frequency and size - The company has a broad definition of women's health and is open to various deal sizes, focusing on those that align with strategic goals [53] Question: Capital allocation and share buyback considerations - Share buybacks are currently a lower priority compared to managing leverage and growth opportunities [68] Question: Impact of tariffs on future operations - The company has minimal exposure to tariffs in 2025 and is well-positioned to navigate potential future changes [66][76] Question: Nexplanon generic competition and FDA issues - Management is confident in the strength of Nexplanon's patents and the regulatory challenges faced by potential generic competitors [85][90]

Financial Data and Key Metrics Changes - The company reported total revenues of $15.5 billion, reflecting a decrease of 2% year-over-year, or an increase of 1% when excluding foreign exchange impacts [23][12] - Earnings per share (EPS) were reported at $2.22, with a gross margin of 82.2%, an increase of one percentage point due to a favorable product mix [35][34] - The company maintained its full-year revenue guidance of between $64.1 billion and $65.6 billion, representing growth of 1% to 3% excluding foreign exchange impacts [35][36] Business Line Data and Key Metrics Changes - In oncology, sales of Keytruda grew 6% to $7.2 billion, driven by increased uptake in earlier-stage cancers and robust demand for metastatic indications [25] - GARDASIL sales decreased by 40% to $1.3 billion, primarily due to reduced demand in China, while global growth excluding China was strong at 16% [27] - The animal health business saw sales increase by 10%, reflecting higher demand across all species and contributions from the Aqua portfolio acquired from Elanco [32] Market Data and Key Metrics Changes - The decline in GARDASIL sales in China was approximately $1.1 billion, which reduced growth excluding foreign exchange by seven percentage points [24] - Outside of the US and China, GARDASIL experienced strong demand, particularly from a catch-up cohort in Japan [27] - The company noted that the ongoing launch of WinRevair generated global sales of $280 million, with significant uptake in both the US and international markets [30] Company Strategy and Development Direction - The company is focused on balancing its manufacturing footprint and has invested $12 billion in US manufacturing since 2018, with an additional commitment of over $9 billion through 2028 [11][10] - The strategic direction emphasizes the advancement of a robust pipeline, with over 20 promising new products expected to launch in the coming years, potentially generating over $50 billion in commercial opportunities by the mid-2030s [16][19] - The company is committed to maintaining its dividend and prioritizing investments in business development to drive growth and returns for shareholders [42][44] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to navigate the current dynamic global environment and emphasized the importance of innovation in addressing health challenges [10][20] - The management team highlighted the ongoing efforts to mitigate potential impacts from tariffs and emphasized a strong inventory position to manage short-term challenges [13][75] - The company remains optimistic about its long-term growth prospects, particularly in light of its expanding late-phase pipeline and the potential for new product launches [18][19] Other Important Information - The company is actively evaluating opportunities for science-driven business development transactions, despite the complexities introduced by the current macroeconomic environment [92][94] - Management acknowledged the disconnect between market realities and seller expectations in the current business development landscape [94] - The company is open to working with the administration on pricing reforms to address the price differentials between the US and international markets [96][100] Q&A Session Summary Question: Can you discuss Merck's mitigating strategies regarding tariffs? - Management highlighted ongoing changes to the supply chain strategy and investments in US manufacturing to mitigate tariff impacts, with a focus on optimizing supply chain operations [70][72] Question: What is the long-term guidance for KEYTRUDA given patent expiry concerns? - Management emphasized confidence in the long-term pipeline, with over 20 new products expected to launch, which could offset concerns related to KEYTRUDA's patent expiry [78][80] Question: Can you comment on the FDA's recent changes and their impact on vaccines? - Management noted that while there are active dialogues with the FDA regarding imminent PDUFA dates, the long-term impact of personnel transitions remains uncertain [85][86] Question: What is the environment for business development given macro volatility? - Management confirmed that the focus on business development remains unchanged, although the current environment presents complexities in executing deals [92][94] Question: What are the prospects for GARDASIL growth and pricing adjustments? - Management indicated that while GARDASIL growth is expected to slow, particularly in China, they remain committed to ensuring the vaccine's value is understood in pricing discussions [132][130]

Financial Data and Key Metrics Changes - The company reported total revenues of $15.5 billion, reflecting a decrease of 2% year-over-year, or an increase of 1% when excluding foreign exchange impacts [23][12] - Earnings per share (EPS) were reported at $2.22, with a gross margin of 82.2%, an increase of one percentage point due to a favorable product mix [35][34] - The company maintained its full-year revenue guidance of between $64.1 billion and $65.6 billion, representing growth of 1% to 3% excluding foreign exchange impacts [36][35] Business Line Data and Key Metrics Changes - In oncology, sales of Keytruda grew 6% to $7.2 billion, driven by increased uptake in earlier-stage cancers and robust demand for metastatic indications [25] - GARDASIL sales decreased by 40% to $1.3 billion, primarily due to reduced demand in China, while global growth excluding China was strong at 16% [27][24] - The animal health business saw sales increase by 10%, reflecting higher demand across all species and contributions from the Aqua portfolio acquired from Elanco [32] Market Data and Key Metrics Changes - The decline in GARDASIL sales in China was approximately $1.1 billion, which reduced growth excluding foreign exchange by seven percentage points [24] - Outside of the US and China, GARDASIL experienced strong demand, particularly from a catch-up cohort in Japan [27] - The company noted that the ongoing launch of WinRevair generated global sales of $280 million, with significant uptake in both the US and international markets [30] Company Strategy and Development Direction - The company is focused on balancing its manufacturing footprint and has invested $12 billion in US manufacturing since 2018, with an additional commitment of over $9 billion through 2028 [11][10] - The strategic direction emphasizes the advancement of a robust pipeline, with over 20 promising new products expected to launch in the coming years, potentially generating over $50 billion in commercial opportunities by the mid-2030s [16][19] - The company is committed to maintaining its dividend and prioritizing investments in business development to drive growth and returns for shareholders [42][44] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the outlook for improved growth in the second half of the year, despite challenges from tariffs and foreign exchange impacts [12][13] - The company is well-positioned to navigate the potential impacts of tariffs due to its global supply chain and inventory management strategies [13][70] - Management highlighted the importance of scientific leadership and innovation as key drivers for long-term value creation [20][19] Other Important Information - The company has nearly tripled its late-phase pipeline since 2021, with significant advancements in oncology, cardiometabolic diseases, and HIV treatments [16][14] - The FDA has set PDUFA dates for several key products, including subcutaneous pembrolizumab and doravirine-based regimens, indicating a strong pipeline of upcoming approvals [60][56] Q&A Session Summary Question: Can you discuss Merck's strategies to mitigate tariffs? - Management highlighted ongoing efforts to rebalance the supply chain and invest in US manufacturing to mitigate the impact of existing tariffs, with a focus on optimizing supply chain strategies [70][72] Question: What is the long-term guidance for KEYTRUDA? - Management emphasized confidence in the long-term potential of the pipeline, with over 20 new products expected to drive significant revenue growth, but did not provide specific line-by-line guidance [78][79] Question: Can you comment on the FDA's recent changes and their impact on vaccines? - Management noted that while there are active dialogues with the FDA regarding imminent PDUFA dates, the long-term impact of personnel transitions remains uncertain [85][86] Question: What is the environment for business development given current macroeconomic conditions? - Management acknowledged the complexities in the current environment but reaffirmed their commitment to pursuing science-driven business development opportunities [92][94] Question: What are the expectations for GARDASIL growth moving forward? - Management indicated that while GARDASIL growth is expected to slow, strong growth is anticipated outside of China, and they are focused on maximizing opportunities in the market [132][131]

Financial Data and Key Metrics Changes - Total company revenues for Q1 2025 were approximately $11.2 billion, reflecting strong demand across the growth portfolio, with an 18% increase in global sales of the growth portfolio [29][38] - Gross margin was approximately 73%, primarily due to product mix, and diluted earnings per share were $1.80 [37][38] - The company is increasing its full-year revenue guidance to a range of $45.8 billion to $46.8 billion, reflecting strong performance and a favorable impact of approximately $500 million related to foreign exchange rates [42][45] Business Line Data and Key Metrics Changes - The immuno-oncology (IO) portfolio, Breyanzi, Reblozyl, and Camzyos were key contributors to the growth portfolio, with Breyanzi's sales more than doubling and international sales tripling [10][32] - Cobenfi, launched in Q1, generated approximately $27 million in sales, tracking ahead of all branded schizophrenia launch benchmarks [36][116] - Eliquis global sales were down 3% due to the impact of Medicare Part D redesign, while Camzyos sales nearly doubled, benefiting from strong global demand [33][34] Market Data and Key Metrics Changes - The growth portfolio's global sales increased approximately 18%, driven by key brands, while the legacy portfolio is expected to decline approximately 16% to 18% for the year [29][42] - The company is seeing strong early uptake of Cobenfi, with approximately 40% to 50% of prescriptions now in second and third-line treatments [56][116] - The company expects total Eliquis revenue to be stronger in the second half of the year due to the Part D redesign and elimination of the coverage gap [34] Company Strategy and Development Direction - The company is focused on maximizing its growth portfolio, accelerating its R&D pipeline, driving operational excellence, and strategically allocating capital [8][22] - Business development remains a top priority, with the company actively pursuing opportunities that can enhance its growth profile [22][94] - The company is taking deliberate actions to rightsize its cost structure and become more efficient, expecting to realize approximately $2 billion in annual cost savings by the end of 2027 [24][40] Management's Comments on Operating Environment and Future Outlook - The current global operating climate presents uncertainty related to tariffs and potential economic downturns, but the company remains confident in its ability to navigate these complexities [25][26] - Management emphasized the importance of strong execution and maintaining a robust pipeline with significant growth potential [26][68] - The company is committed to innovating for patients and advancing first and/or best-in-class medicines through internal discovery and business development [22][68] Other Important Information - The company is on track to pay down $10 billion of debt relative to its March 31, 2024 balance and has maintained its strategic and balanced approach to capital allocation [38][39] - The company has a strong cash position with approximately $12.1 billion in cash equivalents and marketable securities as of March 31 [38] Q&A Session Summary Question: Can you provide any color on the company's US manufacturing footprint ability to shift manufacturing to the US over time? - Management appreciates the administration's efforts to enhance US manufacturing and has been investing in core infrastructure in the US for many years [52][53] Question: How do you think about the future pipeline and riskiness of it? - Management remains confident in delivering growth ambitions driven by the internal R&D pipeline, despite recent setbacks [66][68] Question: How does the readout from ARISE impact your confidence in Alzheimer's psychosis readout? - Management stated that ARISE data has no impact on confidence regarding Alzheimer's disease psychosis trials [80] Question: What are your expectations for the bar for the Alzheimer's psychosis study? - Management indicated that statistical significance in the primary endpoint for hallucinations and delusions is required, but no specific number is predefined [130] Question: Can you provide comments on Bristol's perspective regarding committed capital expenditure going forward? - Management confirmed plans to continue investing in core infrastructure related to R&D and technology in the US [138] Question: How do you approach making M&A decisions in the context of internal success rates? - Management does not tie M&A decisions to specific data readouts but focuses on sourcing new science and innovation that can enhance the growth profile [140][142]

Financial Data and Key Metrics Changes - For the full year 2024, revenue was $6.4 billion, representing a 3% growth rate at constant currency, marking the third consecutive year of constant currency revenue growth [7] - Adjusted EBITDA was $1.96 billion, with a 30.6% adjusted EBITDA margin; excluding IPR&D, the margin was 31.8%, reflecting a half-point margin expansion over the previous year [8][47] - The company expects 2025 revenue to range from $6.125 billion to $6.325 billion, with an approximate $200 million headwind from foreign currency [9][56] Business Line Data and Key Metrics Changes - The women's health franchise grew 5% ex-exchange, driven by Nexplanon, which saw a 17% increase ex-FX, positioning it for at least $1 billion in revenue in 2025 [11][12] - The fertility franchise declined by 2% ex-exchange in 2024, impacted by a late 2023 buy-in and offset by growth in new launches in various regions [15] - The biosimilars franchise grew 12% at constant currency, with expectations of mid-single-digit declines in 2025 due to mature products [16][17] Market Data and Key Metrics Changes - Outside the U.S., strong growth was noted in the LAMERA region, particularly in Brazil and the U.K. [12] - The U.S. market benefited from Nexplanon's leadership and pricing strategies, including management of the 340B discount program [12] - The company anticipates a $200 million impact from foreign exchange in 2025, reflecting the strengthening U.S. dollar [60] Company Strategy and Development Direction - The company aims to demonstrate resiliency in its base business, capture efficiencies, consistently deploy capital, and deliver on growth products and pipeline [22][25] - The focus is on profitable growth, with a commitment to regular dividends as the top capital allocation priority [24][52] - The company plans to launch a Denosumab biosimilar in collaboration with Shanghai Henlius, pending FDA approval [17][33] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about Nexplanon's future growth, especially with the potential five-year indication submitted to the FDA [13] - The company expects to manage through the loss of exclusivity of Atozet in Europe while offsetting it with growth in other products [9][57] - Management highlighted the potential for continued constant currency revenue growth in 2025 despite challenges [68] Other Important Information - The company achieved $967 million of free cash flow before one-time costs in 2024, with expectations of around $900 million for 2025 [48][75] - One-time spin-related costs were $160 million in 2024, with expectations for these costs to be essentially zero in 2025 [50] - The adjusted gross margin for 2025 is expected to be in the range of 60% to 61%, reflecting ongoing pricing pressures [61] Q&A Session Summary Question: Free cash flow estimate for 2025 and biosimilar opportunity for Denosumab - The company expects around $900 million of free cash flow before one-time items for 2025, with confidence in the denosumab biosimilar launch later in Q4 [75][76] Question: Status of Nexplanon and future growth ambitions - No paragraph four filing for Nexplanon has been received, and management is confident that no generics will enter the U.S. market before 2030 [80][85] Question: Competitive landscape for Vtama and margin improvements - Vtama has shown strong growth, with a 51% increase in NRX, and is expected to be a significant contributor to growth [92] - Margin improvements from manufacturing separation from Merck are anticipated to be around 250 to 300 basis points starting in 2027 [96] Question: Future plans for the dermatology business and net leverage targets - The company aims to build out its dermatology portfolio beyond Vtama and expects to reduce net leverage to below four times by the end of 2026 [106][107]