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维立志博-B(9887.HK):【维立志博】41BB和TCE双抗平台已验证 下一代IO和ADC疗法全布局
Ge Long Hui· 2026-01-22 19:29
Core Insights - The company is strategically positioned in the next-generation tumor immunotherapy space through its platforms, including the Agonist platform, TCE platform, and ADC, focusing on innovative targets and differentiated pipelines [1] Group 1: Product Development - LBL-024 (PDL1/4-1BB bispecific antibody) has shown historical best data in lung neuroendocrine carcinoma, with excellent efficacy in first-line SCLC and promising preliminary results in NSCLC; it demonstrates a low incidence of ≥3 grade liver enzyme elevation at only 1.3%, indicating superior safety [2] - LBL-034 (GPRC5D/CD3 bispecific antibody) has a 2:1 structure that enhances TAA binding while balancing efficacy and safety; in I/II clinical studies, it achieved an ORR of 77.8% at 400μg/kg and 90.9% at 800μg/kg, comparable to CAR-T efficacy [3] Group 2: Clinical Research and Pipeline - LBL-024 is the first 4-1BB targeted molecule to reach critical clinical stages globally, with ongoing clinical research approved in multiple cancer types including SCLC, BTC, OC, and others, showing promising clinical effects [2] - Other pipeline developments include BDCA2×TACI expected to file IND in the second half of 2025, a CD19/BCMA/CD3 trispecific antibody IND anticipated in Q1 2026, and DLL3 TCE ADC expected to file IND in the first half of 2027 [3] Group 3: Financial Projections - Revenue forecasts for the company are projected at 1.80 billion, 0.94 billion, and 0.10 billion yuan for 2025, 2026, and 2027 respectively, with growth rates of 833%, -48%, and -90% [3] - Using a DCF model with a WACC of 8.78% and a perpetual growth rate of 1%, the company's fair stock price is estimated at 101.86 HKD, leading to a fair market capitalization of 20.3 billion HKD [3]