Core Viewpoint - The article discusses the upcoming 2025 Conference of Industrial Biotechnology and Biomanufacturing in Tianjin, China, focusing on advancements in synthetic biology and biomanufacturing technologies. Group 1: Conference Details - The conference will take place on October 25, 2025, in Tianjin, China [3]. - It will feature various sub-forums, including one on green biosynthesis of chemicals [3]. Group 2: Key Speakers and Their Contributions - Hui-Min Yin, a professor at Tsinghua University, will discuss new methods and applications in synthetic biology and advanced biomanufacturing, having led over 50 research projects and published more than 160 papers [3]. - Shou-Wen Chen from Hubei University will present on the construction and application of a cell factory platform, having developed key technologies for producing various bioproducts and generating over 1 billion yuan in tax revenue for enterprises [4]. - Jian-Jun Qiao from Tianjin University will cover applications of quorum sensing and synthetic biology, with over 100 published papers and 20 patents [7]. - Jin Hou from Shandong University will focus on metabolic engineering for synthesizing Vitamin A, contributing significantly to yeast synthetic biology [8]. - Bo Yu from the Chinese Academy of Sciences will discuss rational design of synthetic pathways and enzymes, with over 100 publications and 20 patents in the field [9]. - Gao-Yi Tan from East China University of Science and Technology will present on gene editing tools and metabolic engineering, with 47 published papers and 25 patents [10]. - Xin-Na Zhu from the Chinese Academy of Sciences will address the regulation of material and energy metabolism in microbial cell factories [11]. Group 3: Registration and Payment Information - Registration fees are set at 2500 yuan for regular attendees and 1500 yuan for students, with deadlines for payment noted [18]. - Payment methods include bank transfer, payment codes, and credit card processing [20][21].

Core Viewpoint - The article discusses the advancements in the biosynthesis of 1,4-butanediol (BDO) through engineered Escherichia coli, highlighting the challenges and breakthroughs in creating a sustainable production method without antibiotics or inducers [2][3][7]. Group 1: BDO Production Challenges - BDO biosynthesis faces three main challenges: lack of natural BDO-producing microorganisms, significant carbon loss during synthesis, and high dependency on antibiotics and inducers, leading to increased costs [3]. Group 2: Engineering Breakthroughs - Researchers at Zhejiang University have developed a high-efficiency BDO synthesis strain by systematically engineering E. coli, resulting in a production of 0.1 g/L of BDO initially, which was later optimized to 0.82 g/L [6]. - The optimal enzyme combination for BDO production was identified, including enzymes from various bacteria, and a mutant enzyme variant was created that increased BDO yield by 11.19 times [6]. - By knocking out the pdhR gene, the researchers enhanced the conversion efficiency of pyruvate to acetyl-CoA, significantly reducing pyruvate accumulation and increasing BDO yield by 44% to 1.83 g/L [6]. Group 3: Antibiotic-Free Fermentation System - A significant advancement was the development of an antibiotic-free fermentation system, where the researchers utilized E. coli's native transcriptional regulatory elements to drive BDO synthesis without external inducers [7]. - The engineered strain B21-pT19 achieved a remarkable BDO production of 34.63 g/L in a 5 L reactor over 72 hours, maintaining stable yields across multiple fermentation batches without the need for antibiotics or inducers, marking the highest reported level of BDO production to date [7].

Report Summary 1. Report Industry Investment Rating No information provided. 2. Core Viewpoints - The company adheres to the development mission of empowering global agriculture with biological and digital technologies, focusing on the "biotechnology + digital technology" dual - wheel drive for global agricultural modernization transformation, aiming to become a leading global agricultural technology service enterprise [25][26][28]. - In 2025 H1, the company achieved stable business development, with overall revenue of 684.5976 million yuan, a year - on - year increase of 6.50%. The modern agriculture business achieved revenue of 122.3698 million yuan, a year - on - year increase of 13.31% [28][31][34]. - The company will continue to deepen its global strategic layout, optimize resource allocation, upgrade product structure, and improve operational efficiency to enhance profitability and sustainable development capabilities [31][36]. 3. Summary by Directory 3.1. Research Basic Situation - Research object: Fubang Co., Ltd. - Industry: Fertilizer industry - Reception time: August 26, 2025 - Reception personnel: Company's chairman and general manager Wang Renzong, independent director Guo Fei, deputy general manager and financial controller Wan Gang, deputy general manager and board secretary Yi Min [16] 3.2. Detailed Research Institutions - The reception objects are investors who participated in the company's 2025 semi - annual online performance briefing through the Panorama Network live interactive platform [19]. 3.3. Research Institution Proportion No information provided. 3.4. Main Content Data - **Agro - chemical Auxiliary Business**: In 2025 H1, the auxiliary business won the title of "No. 1 in global fertilizer auxiliary sales" by Sullivan, achieving revenue of 496.4149 million yuan, a year - on - year increase of 5.62%. The company promotes transformation and upgrading, focusing on R & D of customized products in the domestic market and expanding overseas markets through localization operations [23]. - **Core Technologies and Products**: The company focuses on technological innovation, researching and applying new materials, and launching products and service models in biological and digital agriculture, aiming to build a modern agricultural ecosystem [24]. - **Land Transfer**: The company built a digital agriculture industrial park in Sanhe Town, Yingcheng City, introducing intelligent technologies in facility agriculture [25]. - **Modern Agriculture Business Strategy**: The biological agriculture segment focuses on four product areas and builds a full - chain R & D system. The digital agriculture segment provides full - process products and services, aiming to build a modern agricultural ecosystem [26]. - **Digital Economy Layout**: The company responds to national strategies, introduces advanced technologies, and sets up the "Tomato Commune" as a demonstration park [26][27]. - **Performance of Modern Agriculture Business**: In 2025 H1, it achieved revenue of 122.3698 million yuan, a year - on - year increase of 13.31%. It made progress in R & D, market expansion, and established a new marketing model [28]. - **Digital Agriculture Layout**: The company focuses on "biotechnology + digital technology", and has advantages in digital soil testing, intelligent water and fertilizer management, and orchard yield estimation [29]. - **Sub - company Wuhan Sotu Data Technology Co., Ltd.**: It developed a "soil digital map" and related digital solutions, currently in the demonstration application stage [30]. - **Overseas Cooperative Organization**: The company established Forbon Technology Netherlands Holdings Co. Cooperatief U.A. in the Netherlands in 2015 to promote international cooperation and business development [30]. - **2025 H1 Operating Performance**: The company achieved revenue of 684.5976 million yuan, a year - on - year increase of 6.50%. Domestic revenue was 365.0579 million yuan, a year - on - year increase of 5.10%, accounting for 53.32% of total revenue; overseas revenue was 319.5397 million yuan, a year - on - year increase of 8.16%, accounting for 46.68% of total revenue [31]. - **Exchange Rate Risk Management**: The company uses natural hedging and diversified settlement strategies to reduce the impact of exchange rate fluctuations [32]. - **Auxiliary Business R & D**: The company focuses on R & D of high - efficiency and environmentally friendly auxiliary products and promotes frontier project research [33]. - **Investment in Wuhan Shuanglvyuan Chuangxin Technology Co., Ltd.**: It developed a leading genomic intelligent breeding system based on biological breeding gene chips [33]. - **Market Promotion of Biological Agriculture Products**: The company's products in biological agriculture are in the demonstration and verification stage, and the "Tianshengdan" project is being promoted [34]. - **Reasons for Net Profit Decline in 2025 H1**: The company increased strategic investment, promoted large - scale demonstration projects, and faced impacts from overseas market expansion [34][35][36]. - **Measures to Address Financial Risks**: The company will improve the capital management system, evaluate goodwill regularly, and actively communicate with the market [36].

Core Insights - The research published in the journal "Nature Chemistry" reveals that E. coli can convert a molecule derived from waste plastic bottles into the painkiller acetaminophen, suggesting a sustainable method to upgrade plastic waste into useful products [1][2] Group 1: Research Findings - Plastic waste is an increasingly serious issue, and upgrading it sustainably remains a primary task [1] - The study utilized metabolic engineering to combine chemical reaction networks used in biological cells to produce desired molecules, although the effectiveness of this approach in upgrading plastic into useful products was previously unclear [1] - The research identified a chemical reaction called rearrangement catalyzed by phosphate in E. coli, which produces nitrogen-containing organic compounds essential for cell metabolism [1] Group 2: Production Efficiency - The study demonstrated that the molecule derived from plastic can serve as a starting material for producing acetaminophen in E. coli, achieving a yield of 92% [2] - The authors suggest that this research may be the first instance of generating acetaminophen from waste using E. coli, indicating potential for further exploration of other bacteria or plastics to produce useful products [2]

Core Viewpoint - Anhui Huaheng Biological Technology Co., Ltd. plans to invest RMB 320 million in the construction of an "Artificial Intelligence Precision Fermentation and Protein Engineering Shared Demonstration Project" to maintain its industry leadership and meet market demand for high-quality, low-cost products [1][2]. Investment Overview - The investment amount for the project is RMB 320 million, primarily funded by self-owned or self-raised funds, with a construction period of 36 months [1][2]. - The project is located in the northeast corner of the intersection of Shuangfeng Road and Yingzhou Road in the Shuangfeng Economic Development Zone, Changfeng County [1]. Decision and Approval Process - The investment decision was approved by the company's management and does not require board approval, as it falls within the management's authority [1][2]. - The company has signed a total of RMB 710 million in investment agreements with the Changfeng (Shuangfeng) Economic Development Zone Management Committee over the past 12 months [2]. Project Details - The project aims to utilize advanced microbial fermentation technology combined with artificial intelligence for precise control of the fermentation process, enhancing production efficiency and product quality [5]. - The project will establish a smart production system, improving the company's core competitiveness in the market [5]. Environmental and Safety Compliance - The company is required to adhere to national environmental protection standards and energy-saving regulations during the construction and operation of the project [4]. - The project must comply with safety management laws and regulations, ensuring proper handling of wastewater, waste gas, and solid waste [4].