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沈阳农业大学发表Nature子刊论文:生酮饮食能够抗疟疾
生物世界· 2025-05-24 03:13
Core Viewpoint - The emergence of drug-resistant malaria parasites necessitates the development of new treatment strategies, with a focus on dietary and metabolic interventions to combat malaria infection [2][4]. Group 1: Research Findings - A study published by a team from Shenyang Agricultural University indicates that a ketogenic diet can inhibit the growth of Plasmodium falciparum and confer protection against malaria in mice [3][4]. - The mechanism involves β-hydroxybutyrate (β-OHB), a ketone body produced during a ketogenic diet, which halts the development of malaria parasites, highlighting the potential of dietary strategies in malaria prevention [4][9]. - The study found that high levels of β-OHB in the blood disrupt the biological regulation mechanisms of malaria parasites, leading to their developmental stasis [9][11]. Group 2: Mechanisms of Action - β-OHB not only serves as an energy source but also acts as a signaling molecule that influences metabolic regulation, inflammation, and oxidative stress pathways [8]. - The inhibition of histone deacetylase (HDAC) by β-OHB results in increased histone acetylation levels, which can lead to gene expression alterations and protective effects against oxidative stress in mouse tissues [8][9]. - The research demonstrated that both ketogenic diets and direct supplementation of β-OHB can induce metabolic reprogramming in malaria parasites, reducing their NAD levels and downregulating genes associated with their development and virulence [11]. Group 3: Implications for Malaria Treatment - The findings suggest that dietary and metabolic interventions, particularly through ketogenic diets and β-OHB, could be promising strategies for developing new anti-malarial treatments [4][11]. - The study emphasizes the antimicrobial potential of metabolic interventions, as highlighted in a concurrent article in Nature Metabolism, which discusses the protective effects of β-OHB against malaria [11].