Core Points - The Lasker Awards are prestigious biomedical awards in the U.S., established in 1946, recognizing significant contributions in the medical field, often seen as a precursor to the Nobel Prize [2][3] - The 2025 Lasker Award winners include six scientists recognized for their groundbreaking work in basic and clinical medicine [3] Group 1: Lasker Basic Medical Award - Winners: Dirk Görlich and Steven L. McKnight for their discoveries regarding the structure and function of low-complexity domains (LCDs) in proteins, which elucidate new principles of intracellular transport and organization [7][26] - Their research challenges traditional views that LCDs, composed of a limited number of amino acids, are insignificant, revealing that approximately 15%-20% of eukaryotic proteins contain such domains that play crucial roles in various physiological functions [7][26] Group 2: Lasker Clinical Medical Award - Winners: Michael J. Welsh, Jesús González, and Paul A. Negulescu for their pivotal role in developing a three-drug combination therapy for cystic fibrosis, transforming it into a manageable condition [29] Group 3: Lasker Special Achievement Award - Winner: Lucy Shapiro for her 55 years of contributions in bacterial cell biology and national leadership, including the establishment of Stanford University's developmental biology department and her advisory role on issues like antibiotic resistance [30]