以下文章来源于内分泌早知道 ，作者关注内分泌的 内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展，「每医健」旗下内容平台。 最新研究显示，当实验小鼠的饮食中去除半胱氨酸后，短短7天内体重骤降30%，这一突破性发现为代谢调控研究开辟了新方向。 在全球肥胖问题日益严峻的背景下，这项研究无疑为理解体重调控机制提供了全新视角。 当前全球肥胖人口已突破总人口的六分之一，传统减肥方式如低碳饮食、生酮疗法等虽然各具特色，但效果参差不齐。这项发表在权威 期刊的研究首次揭示，半胱氨酸在能量代谢中扮演着关键角色。实验过程中，研究人员观察到停止供应该氨基酸的小鼠不仅体重急剧下 降，更令人惊讶的是，在恢复正常饮食后，其体重能够快速回升。这种可逆的体重变化模式暗示着人体内可能存在着类似代谢"开关"， 为未来开发新型减肥干预措施提供了重要线索。 深入分析表明，半胱氨酸缺乏可能触发了某种未知的代谢重编程机制。科学家推测，这种氨基酸或是连接能量摄入与消耗的重要媒介， 其缺失直接导致体内能量平衡系统发生剧烈调整。值得注意的是，这种减重效果远超现有饮食干预手段，其背后隐藏的分子机制或将改 写我们对体 ...

Core Viewpoint - The latest research reveals that the removal of cysteine from the diet of experimental mice leads to a dramatic weight loss of 30% within just seven days, opening new avenues for metabolic regulation research [4][6][10]. Group 1: Research Findings - The study published in the journal "Nature" indicates that cysteine plays a crucial role in energy metabolism, and its absence triggers significant metabolic reprogramming [6][9][11]. - Mice lacking the ability to synthesize cysteine experienced a drastic weight loss, suggesting that cysteine is a central regulatory point for energy balance [7][10]. - The weight loss effect observed in the cysteine-deficient group surpassed that of traditional dietary interventions, even when caloric intake was maintained [7][10]. Group 2: Mechanisms of Action - The absence of cysteine leads to a fundamental shift in metabolic patterns, including a significant reduction in the respiratory exchange ratio and an increase in fat burning efficiency [7][11]. - White adipose tissue underwent "browning," characterized by the expression of thermogenic protein UCP1, indicating a shift towards a fat-burning state [7][10]. - The activation of dual stress pathways in the liver was noted, which involves the phosphorylation of eIF2α to inhibit protein synthesis and the activation of NRF2 to regulate the antioxidant system [7][11]. Group 3: Implications for Obesity Treatment - This groundbreaking research challenges traditional weight loss theories and suggests that targeting cysteine metabolism could provide new strategies for obesity treatment [6][9][11]. - The reversible nature of weight loss through cysteine restriction offers a safe boundary for clinical applications, allowing for both short-term weight loss and prevention of metabolic disorders [11]. - The findings highlight the dynamic plasticity of amino acid metabolic networks, suggesting that effective weight management may rely on precise regulation of specific metabolic pathways rather than simple caloric restriction [11].