Core Viewpoint - The article emphasizes the significant role of metabolic regulation in mammalian embryogenesis, challenging the traditional view that metabolism merely supports developmental processes passively [2][4]. Group 1: Metabolic Regulation in Early Development - Metabolic needs during early embryonic development are critical, with pyruvate being essential for maintaining redox balance [4]. - The metabolic remodeling drives zygotic genome activation (ZGA), where mitochondrial TCA cycle enzymes temporarily localize to the nucleus in a pyruvate-dependent manner, closely linked to epigenetic reprogramming [4]. - Lactate accumulation in early embryos is crucial, and inhibiting lactate production or uptake can halt development at the two-cell stage [4]. Group 2: Metabolic Changes During Blastocyst Formation - As embryos progress from the two-cell stage to the blastocyst stage, significant metabolic activity changes occur, including increased mitochondrial activity and enhanced pyruvate oxidation [4]. - The dynamic changes in lipids during this stage are vital for establishing polarity in the outer cells of the morula [4]. Group 3: Metabolic Activity During Implantation - Lipids and their derivatives are essential for blastocyst implantation, with fatty acid-related inflammatory responses aiding in establishing the maternal-fetal interface and optimizing uterine receptivity [4]. Group 4: Metabolic Features in Gastrulation and Organogenesis - Metabolic gradients, such as spatially and temporally specific glucose metabolism waves, play a regulatory role in gastrulation [4]. Group 5: Metabolic Characteristics of Embryo Dormancy - Increased autophagic activity generates more nutrients, and higher levels of taurine and hypotaurine provide antioxidant protection during embryo dormancy [4]. Group 6: Advanced Methods for Assessing Embryonic Metabolism - The article discusses advanced methods for evaluating embryonic metabolism, including metabolomics for small embryos, spatial metabolomics, and Raman spectroscopy for assessing embryo quality in vitro [4].

以下文章来源于内分泌早知道 ，作者关注内分泌的 内分泌早知道 . 深度分享内分泌用药经验、病例剖析、指南专业解读并紧跟国内外内分泌领域前沿进展。 最新研究显示，当实验小鼠的饮食中去除半胱氨酸后，短短7天内体重骤降30%，这一突破性发现为代谢调控研究开辟了新方向。 在全球肥胖问题日益严峻的背景下，这项研究无疑为理解体重调控机制提供了全新视角。 当前全球肥胖人口已突破总人口的六分之一，传统减肥方式如低碳饮食、生酮疗法等虽然各具特色，但效果参差不齐。这项发表在权威 期刊的研究首次揭示，半胱氨酸在能量代谢中扮演着关键角色。实验过程中，研究人员观察到停止供应该氨基酸的小鼠不仅体重急剧下 降，更令人惊讶的是，在恢复正常饮食后，其体重能够快速回升。这种可逆的体重变化模式暗示着人体内可能存在着类似代谢"开关"， 为未来开发新型减肥干预措施提供了重要线索。 深入分析表明，半胱氨酸缺乏可能触发了某种未知的代谢重编程机制。科学家推测，这种氨基酸或是连接能量摄入与消耗的重要媒介， 其缺失直接导致体内能量平衡系统发生剧烈调整。值得注意的是，这种减重效果远超现有饮食干预手段，其背后隐藏的分子机制或将改 写我们对体重调节的认知。随着研究的 ...