Core Viewpoint - The release of new national food safety standards regarding pesticide maximum residue limits will enhance the standardization of pesticide residue detection technology in China, providing reliable technical support for agricultural product quality safety regulation [1][2]. Group 1: Regulatory Developments - The National Health Commission, Ministry of Agriculture and Rural Affairs, and State Administration for Market Regulation jointly issued seven national food safety standards, effective from March 1, 2026 [1]. - The revised national standards specify detection methods for over 500 pesticides and their metabolites in plant-based foods, covering all major pesticide varieties currently registered for use in China [1]. Group 2: Technological Advancements - The development of integrated rapid pretreatment technology, combined with high-throughput tandem mass spectrometry analysis, addresses issues related to traditional detection methods, such as complex pretreatment processes and low sensitivity and precision [2]. - The new standards are expected to be widely applied in national agricultural product quality safety risk monitoring, national food safety supervision sampling, and local agricultural and food safety regulation [2].

Core Viewpoint - The article evaluates the compensation efficiency of six composite analytical protectants in pesticide residue detection in fruits and vegetables using gas chromatography-tandem mass spectrometry (GC-MS/MS) technology, establishing a method for detecting 45 types of pesticide residues with improved recovery rates and sensitivity compared to existing standards [2][4]. Group 1: Methodology and Results - The study utilized an orthogonal test to optimize the formulation of composite protectants, analyzing their effects on matrix effects (ME) during pesticide residue detection [4][6]. - The ideal composite protectant combination, AP3, significantly improved chromatographic peak shapes and achieved comprehensive compensation effects, with a linear range of 2.5–200.0 µg/L and correlation coefficients (r²) greater than 0.995 [4][28]. - Detection limits for winter melon were established at 0.25–1.95 µg/kg, and for pear at 0.16–1.87 µg/kg, with quantification limits for winter melon at 0.91–5.12 µg/kg and for pear at 0.71–5.34 µg/kg [4][28]. Group 2: Analysis of Matrix Effects - The matrix effects were evaluated for 45 pesticide residues, revealing significant differences in ME for the same pesticide across different matrices, with some pesticides exhibiting strong ME in certain fruits [17][24]. - The study identified that the commonly used analytical protectants could vary in their effectiveness based on the type of pesticide and its concentration, necessitating a composite approach for optimal results [6][25]. Group 3: Composite Analytical Protectants - The six analytical protectants evaluated included L-gulonic acid-γ-lactone, D-sorbitol, shikimic acid, 3-ethoxy-1,2-propanediol, D-panthenol, and di(2-hydroxyethyl)iminotris(hydroxymethyl)methane, each contributing differently to ME compensation [4][24]. - The study concluded that while single protectants have limitations, a composite approach can effectively address the diverse nature of pesticide residues in complex matrices [25][28].

Core Viewpoint - The collaboration between Dalian Institute of Chemical Physics and Beijing University of Technology has led to the development of a novel flexible biosensor (PAAP) for the rapid, non-destructive, and highly sensitive detection of the fungicide thiram, with a detection limit as low as 6.57 nM, suitable for on-site food monitoring [1][2][6]. Group 1: Technology and Innovation - The new biosensor utilizes DNA-AgNPs hydrogel microneedles, enabling quick and visual detection of thiram, addressing the urgent need for real-time monitoring in food safety and agricultural environmental monitoring [2][3]. - Traditional detection methods rely on complex and time-consuming laboratory techniques, which are costly and destructive to samples, making them unsuitable for live or on-site monitoring [3][6]. Group 2: Performance and Usability - The biosensor demonstrates excellent selectivity and sensitivity for thiram, with a detection limit of 6.57 nM, meeting trace detection requirements [6]. - The detection process is user-friendly, allowing for semi-quantitative or quantitative analysis through smartphone photography and color analysis software, eliminating the need for large specialized instruments [6][7]. Group 3: Application Prospects - This technology is applicable for rapid screening of thiram residues in various food products, including meat and fruits, and offers a new technical pathway for continuous and live monitoring of pesticide residues during the growth and storage of edible plants and animals [7]. - The research team successfully demonstrated the monitoring of thiram concentration changes in simulated real-world scenarios, validating the feasibility of on-site applications [7]. Group 4: Research Background - The breakthrough is a result of the research team's long-term focus on wearable sensors for aquatic organisms, with previous achievements published in top-tier journals and multiple domestic and international patents filed [8]. - This research marks a significant expansion and transformation of cutting-edge sensor technology into the broader field of food safety monitoring, showcasing a complete innovation chain from basic research to applied solutions [8].