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《自然》重磅解密:少食真能长寿?谷歌抗衰老团队揭示"延寿代价"
GLP1减重宝典· 2025-08-01 08:32
Core Viewpoint - The article discusses the implications of recent research on calorie restriction (CR) and intermittent fasting (IF) on health and longevity, highlighting the potential trade-offs between lifespan extension and overall health [9][11][19]. Summary by Sections Research Findings - A study conducted by Calico Life Sciences in collaboration with other institutions revealed that calorie restriction can extend lifespan significantly, with a 40% CR group showing a lifespan increase of 36.3% compared to ad libitum (AL) groups [13][15]. - Intermittent fasting (IF) showed some benefits in lifespan extension, but its effects were less pronounced than those of calorie restriction, with the 1D and 2D fasting groups showing only slight increases in lifespan [13][19]. Health Implications - While CR can extend lifespan, it may lead to adverse health effects, such as reduced immune function and weight loss, which could increase infection risk [15][19]. - The study found that IF could also have health risks, such as increased red blood cell distribution width (RDW), which is associated with aging and mortality [16][19]. Weight and Longevity Paradox - The research highlighted a paradox where lower body weight does not necessarily correlate with longer lifespan, suggesting that maintaining an appropriate weight and fat content is crucial for longevity [17][19]. - Genetic factors were found to play a significant role in lifespan variation, with 23.6% of lifespan variation in younger mice explained by genetics, compared to only 7.4% by diet [17][19]. Conclusion - The findings suggest that while dietary restrictions can extend lifespan, they may compromise health, indicating a need for caution regarding extreme dieting methods [19]. Further research is required to understand the specific impacts of these dietary practices on human longevity [19].