Core Viewpoint - The research team led by Zhang Xiaoheng at the University of Chinese Academy of Sciences has developed a new technique called "molecular editing" that allows for the safe and efficient conversion of C-N bonds in aromatic amines, facilitating the synthesis of key drug components without hazardous intermediates [1][2]. Group 1 - The "molecular editing" technique enables a smooth and controllable process, allowing ordinary pharmaceutical workers to operate it easily [1]. - This method bypasses the high-risk "diazotization" process that has been used for over a century, making it both safer and more environmentally friendly [1]. - The technique can connect multiple coupling reactions in a single pot, significantly speeding up the modification of drug molecules [1]. Group 2 - The new method is adaptable to nearly all drug molecular structures and can reduce the cost of certain drug intermediates by 40%-50% [1]. - The Zhang Xiaoheng team has already engaged with pharmaceutical companies for the synthesis of intermediates for anti-cancer drugs, indicating practical applications of their research [1]. - The rapid publication of their findings in Nature, just one month after submission, highlights the efficiency and significance of their work, receiving high praise from reviewers and industry experts [1][2]. Group 3 - The breakthrough has been described as a "Nobel Prize-level breakthrough" by Zhou Hongyi, chairman of 360, emphasizing its potential impact [2]. - The research reflects a shift in China's scientific capabilities from following to leading in innovative processes, with more breakthroughs anticipated in green drug synthesis and other areas [2].