整理 | GLP1减重宝典内容团队 如果您怀孕了或者正准备怀孕，您需要了解以下关于使用 GLP-1 药物治疗 2 型糖尿病或肥胖症的信息。 研究人员发现，与母亲在怀孕期间注射胰岛素控制糖尿病相比，母亲使用 GLP-1 药物所生的孩子患先天性缺陷的风险并没有增加。 虽然研究结 果令人鼓舞，但研究人员指出，还需要更多的证据才能排除 GLP-1 对胎儿的潜在风险，而且他们的研究只是迈出了了解这些药物如何影响儿童 发育的第一步。 胰高血糖素样肽 1 (GLP-1) 受体激动剂，如 Ozempic (semaglutide) 和 Trulicity (dulaglutide)，越来越多地用于治疗 2 型糖尿病，在某些情况 下，还用于减肥。如果您患有 2 型糖尿病，您的医生甚至可能提到过尝试其中一种较新的药物。 但是，如果您怀孕或试图怀孕，这些药物可以 安全使用吗？ 现有研究结果并不一致，因此专家建议女性在这种情况下暂时停止或推迟开始使用 GLP-1 药物。 "需要进行更多研究来确定在怀孕期间服用司美格鲁肽或其他 GLP-1 是否安全，"凤凰城亚利桑那州妇女健康中心的妇产科医生Monte Swarup 医 学博士说。"因 ...

Core Viewpoint - The article discusses the safety concerns and recommendations regarding the use of GLP-1 medications during pregnancy and breastfeeding, highlighting the need for caution and further research in this area [1][3]. Group 1: Research on GLP-1 Medications and Pregnancy - A large study published in January 2024 in JAMA Internal Medicine tracked around 50,000 children born to mothers with type 2 diabetes who used GLP-1 or insulin in early pregnancy, finding no increased risk of congenital defects compared to insulin use [5]. - Another study published in 2023 reviewed 39 independent studies on the effects of GLP-1 agonists and SGLT2 inhibitors during pregnancy and breastfeeding, concluding that there is extremely limited information on their safety [6]. Group 2: Risks Associated with GLP-1 Use During Pregnancy - Potential risks of GLP-1 medications during pregnancy may include miscarriage, low birth weight, and congenital defects, primarily due to their impact on maternal food intake and weight gain [6][7]. - Although concerns are mainly based on animal studies, the lack of human research has led to recommendations for discontinuation during pregnancy [7]. Group 3: Recommendations for Women Planning to Become Pregnant - Women are advised to stop using any GLP-1 medications at least two months before attempting to conceive, along with adopting additional preconception lifestyle measures [8]. - The American Diabetes Association recommends insulin as the preferred medication for managing diabetes during pregnancy, while other diabetes medications like metformin and glipizide are not first-line treatments due to their placental transfer [7][8]. Group 4: Breastfeeding Considerations - There is insufficient research to determine the safety of GLP-1 medications during breastfeeding, leading to recommendations against their use during this period [9][10].