撰文丨王聪 编辑丨王多鱼 排版丨水成文 对于即将接受外科手术的患者来说， 术后疼痛 是一个令人担忧的问题 ，据统计， 大约 75% 的患者在术 后会出现中度至重度的急性疼痛，且有 50% 的患者无法获得充分的止痛效果。 目前临床上常用的强效镇痛药主要是 阿片类药物 （例如 吗啡 ） ，但它们带来的恶心、呕吐、呼吸抑制等 副作用同样让人望而生畏。如何在有效镇痛与减少副作用之间找到平衡，一直是医学界面临的挑战。 2025 年 12 月 8 日， 华中科技大学同济医学院附属协和医院 陈向东 主任医师 、天津市南开医院 余剑波 主任医师、 河南省人民医院 张加强 主任医师等，在 Cell 子刊 Cell Reports Medicine 上发表了题为： Tegileridine for moderate-to-severe acute pain following abdominal surgery: A randomized, double- blind, phase 3 clinical trial 的研究论文。 这项随机、双盲、3 期临床试验结果表明 ，新型镇痛药物 Tegileridine （泰吉利定，由恒瑞 ...

Core Insights - A research team from the University of Pennsylvania and Scripps Research has discovered a previously overlooked type of brain cell that activates during persistent pain, potentially opening new treatment avenues for chronic pain affecting about 1/5 of the global population [1] Group 1: Research Findings - The focus of the research is on the periaqueductal gray area, specifically the lateral parabrachial nucleus, which acts as a hub for processing sensory information and relaying it to other brain regions [1] - In mouse experiments, a specific subset of neurons carrying neuropeptide Y receptors was identified, which remain active in a "persistent mode" following initial pain stimuli such as nerve injury [1] - Activation of these Y1R neurons in mice resulted in typical pain responses, while blocking their activity significantly alleviated persistent pain without affecting responses to acute threats like high temperatures [1] Group 2: Implications for Pain Treatment - The study indicates that during stress, other brain regions release neuropeptide Y to the lateral parabrachial nucleus, naturally achieving analgesic effects [1] - This physiological mechanism provides crucial insights for the development of new analgesic drugs, with the neuropeptide Y signaling pathway identified as a promising drug target for chronic pain treatment [1]