近日，中国科学院大学杭州高等研究院研究员张夏衡团队与合作企业在《自然》上发表论文，阐述 了他们改造芳香胺的最新研究成果。研究中，他们使用"直接脱氨"新策略，通过廉价试剂将芳香胺中稳 定的碳—氮键替换为功能各异的多种重要化学键，有望规避传统工艺潜在的爆炸风险与重金属污染。这 让从1884年沿用至今的芳香胺应用工艺迎来了新突破，也为解决抗癌药成本难题带来了希望。 该论文从投稿《自然》到正式发表仅用时不到50天，并获得审稿人的高度评价。制药巨头辉瑞公司 高级研发总监斯科特·巴格利在公开审稿意见中称其为"真正的杰作"。 绕开高风险的重氮盐中间体 在微观视角下，很多化合物可以看作由无数"小积木"拼接而成。芳香胺相当于其中的"基础积木"， 在抗癌药物合成等领域有广泛应用，但在拼接过程中，需要将芳香胺原有的氨基去除，将其转化成能拼 接具备各种功能部件的"功能积木"。 在过去的一个多世纪里，工业领域长期沿用一种发明自140年前的传统工艺去除芳香胺的氨基：先 将芳香胺转化为重氮盐中间体，再通过铜盐促进等手段去除氨基，引入新官能团，开展后续转化。传统 工艺的关键问题在于，重氮盐不稳定，具有爆炸危险性。此外，传统工艺还面临铜消耗大 ...

Core Insights - The chemical sector is experiencing a significant influx of funds, with the chemical ETF (159870) seeing a net subscription of 500 million units during trading hours. This is attributed to a new direct deamination strategy developed by a research team from the University of Science and Technology of China, which allows for the replacement of stable carbon-nitrogen bonds in aromatic amines with various important chemical bonds using common and inexpensive reagents, enabling kilogram-scale synthesis [1]. Group 1 - The new technology is considered a "disruption of 140 years," as it eliminates the need for the dangerous diazonium salt intermediate, addressing safety concerns associated with traditional processes that are prone to explosions [1]. - The new method is expected to reduce the synthesis cost of certain drug intermediates, such as anticancer drugs, by 40% to 50%, benefiting multiple fine chemical sectors including pharmaceuticals, pesticides, dyes, pigments, and fragrances [1]. Group 2 - As of October 31, 2025, the top ten weighted stocks in the CSI Sub-Industry Chemical Theme Index (000813) include Wanhua Chemical (600309), Salt Lake Industry (000792), Tianci Materials (002709), Juhua Co. (600160), Cangge Mining (000408), Jinfa Technology (600143), Baofeng Energy (600989), Hualu Hengsheng (600426), Hengli Petrochemical (600346), and Yuntianhua (600096), collectively accounting for 44.83% of the index [2].