Financial Data and Key Metrics Changes - In the first nine months of 2025, the company achieved 15% sales growth and 10% operating profit growth, with guidance narrowed to 8-11% for sales and 4-7% for operating profit due to expected lower growth in GLP-1 treatments for diabetes and obesity [7][35][38] - The gross margin decreased to 81.0% from 84.6% in 2024, primarily due to one-off restructuring costs and impairments [35] - Net profit increased by 4%, and diluted earnings per share rose to DKK 16.99 [37] Business Line Data and Key Metrics Changes - GLP-1 sales in diabetes increased by 10%, while insulin sales grew by 3% [14] - Obesity care sales surged by 41%, with US operations growing by 24% and international operations by 83% [14] - Rare disease sales increased by 13%, driven by a 14% increase in the US [14] Market Data and Key Metrics Changes - In international operations, GLP-1 diabetes sales increased by 10%, with a notable growth in China [16] - The combined diabetes and obesity GLP-1 market share remains at 68% in international operations [17] - Wegovy sales reached approximately DKK 20 billion, growing at 168% across all regions [16] Company Strategy and Development Direction - The company is sharpening its focus on diabetes and obesity, discontinuing non-core assets and reallocating resources to areas aligned with its strengths [10][11] - A company-wide transformation program aims to simplify operations and reallocate capital towards high-growth opportunities, expecting annual savings of approximately DKK 8 billion by the end of 2026 [12] - The company is pursuing acquisitions to enhance its R&D portfolio, including a proposal to acquire Medcera for $6.7 billion [24] Management's Comments on Operating Environment and Future Outlook - Management acknowledged the loss of market share in the GLP-1 market and emphasized the need for strategic initiatives to regain momentum [46][50] - The company remains optimistic about the long-term potential in the diabetes and obesity markets, despite current competitive pressures [78] - Future growth is expected to be impacted by the loss of exclusivity in certain markets and increased R&D costs from acquisitions [92] Other Important Information - The company has submitted Mim8 for regulatory approval in both the US and EU [8] - The FDA approved Wegovy for the treatment of MASH in the US, expanding its market potential [20] - The company anticipates a regulatory decision regarding the Wegovy Pill by the end of 2025 [32] Q&A Session Summary Question: Market share loss in GLP-1 market - Management acknowledged the significant loss of market share and discussed strategic initiatives to expand the market and regain momentum [46][50] Question: Capital allocation and dividend payout - The CFO confirmed a consistent capital allocation framework prioritizing business investment, dividend payments, and potential share buybacks [52][53] Question: Differentiation of Medcera assets - Management expressed excitement about the Medcera acquisition, highlighting the complementary nature of its assets to the existing pipeline [60][61] Question: Medicare opportunities and IRA risks - Management emphasized the importance of Medicare coverage for obesity treatments and acknowledged the potential risks associated with the Inflation Reduction Act [67][70] Question: Device strategy setbacks - Management discussed setbacks with the Wegovy FlexTouch device and plans to explore other device options for market entry [81]

Financial Data and Key Metrics Changes - In the first nine months of 2025, the company achieved 15% sales growth and 10% operating profit growth, with guidance narrowed to 8-11% for sales and 4-7% for operating profit due to expected lower growth in GLP-1 treatments for diabetes and obesity [7][35][38] - The gross margin decreased to 81.0% from 84.6% in 2024, primarily due to one-off restructuring costs and impairments [35] - Free cash flow for the first nine months of 2025 was DKK 63.9 billion, down from DKK 71.8 billion in the same period of 2024 [37] Business Line Data and Key Metrics Changes - GLP-1 sales in diabetes increased by 10%, while insulin sales grew by 3% [14] - Obesity care sales surged by 41%, with U.S. operations growing by 24% and international operations by 83% [14][16] - Rare disease sales increased by 13%, driven by a 14% increase in the U.S. [16] Market Data and Key Metrics Changes - In international operations, GLP-1 diabetes sales increased by 10%, with significant growth in China [16][17] - The combined diabetes and obesity GLP-1 market share for the company remains at 68% in international operations [17] - The company is facing intensifying competition in both diabetes and obesity markets, impacting growth expectations [38] Company Strategy and Development Direction - The company is sharpening its focus on diabetes and obesity, discontinuing non-core assets and reallocating resources to areas aligned with its strengths [10][11] - A company-wide transformation program is underway, expected to reduce approximately 9,000 positions globally, aiming for DKK 8 billion in annual savings by the end of 2026 [12] - The company is pursuing acquisitions to enhance its R&D portfolio, including a proposal to acquire Medcera for $6.7 billion [24] Management's Comments on Operating Environment and Future Outlook - Management acknowledged the loss of market share in the GLP-1 market and emphasized the need for strategic initiatives to regain momentum [46][50] - The company remains optimistic about future growth opportunities in diabetes and obesity, despite current competitive pressures [78] - Management highlighted the importance of expanding access to treatments through partnerships and new product launches [50][88] Other Important Information - The company has submitted Mim8 for regulatory approval in both the U.S. and EU [8] - The Wegovy Pill is anticipated to launch in early 2026, pending regulatory approval [21][90] - The company expects a negative low single-digit impact on global sales growth in 2026 due to the compound patent expiry of semaglutide in certain countries [41] Q&A Session Summary Question: Market share loss in GLP-1 market - Management acknowledged the loss of 9 percentage points in global market share and discussed strategic initiatives to address this issue, including expanding the pipeline and increasing commercial partnerships [46][50] Question: Capital allocation and dividend payout - The company maintains a consistent capital allocation framework, prioritizing investments in the business, paying dividends, and pursuing pipeline additions [48][53] Question: Differentiation of Medcera assets - Management expressed excitement about the Medcera acquisition, emphasizing that the assets are complementary to the existing pipeline and address diverse patient needs [57][60] Question: Medicare coverage and IRA impact - Management highlighted the importance of Medicare coverage for obesity treatments and acknowledged the potential risks associated with the Inflation Reduction Act [67][70] Question: Device strategy setbacks - Management discussed setbacks with the Wegovy FlexTouch device and indicated plans to explore other device presentations and options for the future [75][81]