据了解，美国食品药品监督管理局(FDA)已于去年12月22日批准这款口服药上市，此举为诺和诺德在与 礼来(LLY.US)的市场竞争中重获优势注入新动力。 此次获批的口服司美格鲁肽片剂与注射型Wegovy及Ozempic活性成分相同，均以Wegovy品牌销售。值 得一提的是，诺和诺德此前已推出针对2型糖尿病的口服司美格鲁肽药物Rybelsus。 诺和诺德(NVO.US)周一表示，自1月5日起，将向美国自费患者推出两种规格的口服减肥药Wegovy，其 中1.5毫克与4毫克剂型月定价为149美元。据该公司官网信息，同日上市的还有两款高剂量口服剂型 ——9毫克与25毫克，月定价为299美元。 公告同时指出，4毫克剂型的售价将于4月15日起上调至每月199美元。 ...

Bagsværd, Denmark, 31 December 2025 – Today, the Supreme People’s Court in China made a positive decision concerning the intellectual property rights relating to the semaglutide compound patent. Novo Nordisk is pleased that the Court has upheld the Beijing IP Court ruling recognising the validity of the semaglutide compound patent. “This outcome is very positive for semaglutide and demonstrates firm government support for protecting medical innovation,” said Mike Doustdar, president and CEO of Novo Nordisk. ...

Bagsværd, Denmark, 31 December 2025 – Today, the Supreme People’s Court in China made a positive decision concerning the intellectual property rights relating to the semaglutide compound patent. Novo Nordisk is pleased that the Court has upheld the Beijing IP Court ruling recognising the validity of the semaglutide compound patent. “This outcome is very positive for semaglutide and demonstrates firm government support for protecting medical innovation,” said Mike Doustdar, president and CEO of Novo Nordisk. ...

Core Insights - Novo Nordisk has faced significant challenges over the past 18 months, including clinical setbacks, disappointing financial results, and a loss of market share in its key therapeutic area, leading to a notable decline in stock price [1] - Recent regulatory approval for an oral version of Wegovy, the first oral GLP-1 approved for weight management, has positively impacted Novo Nordisk's share price, increasing it by as much as 8% in one day [1][3] Group 1: Product Developments - Novo Nordisk primarily generates revenue from GLP-1 products, including Wegovy, which is used for diabetes treatment and weight management [2] - The newly approved oral Wegovy is expected to attract more patients by eliminating the need for injections, making it easier and cheaper to manufacture at scale [4] - The approval of oral Wegovy provides Novo Nordisk with a first-mover advantage in the oral weight loss market, potentially helping the company regain market share lost to competitors [5] Group 2: Competitive Landscape - Eli Lilly, a major competitor, is also advancing in the weight loss market with its application for orforglipron, a weight loss pill that has shown promising results in clinical trials [7] - The competitive dynamics in the weight management market are intensifying, with both companies vying for a larger share of the growing demand for weight loss therapies [6][7]

Core Viewpoint - Novo Nordisk has received FDA approval for its oral weight loss drug Wegovy, set to launch in January 2026 at a starting price of $149 per month, potentially making it more accessible than its injectable counterpart [5][14]. Group 1: Novo Nordisk's Product Launch - The oral version of Wegovy is designed to provide weight loss results comparable to the injectable version, with the added convenience of daily oral administration [5]. - The active ingredient in the oral drug is semaglutide, the same as in the injectable Wegovy and Ozempic, but with a higher dosage in the new formulation [5]. - Novo Nordisk has reached an agreement with Trump to allow self-paying patients to purchase the drug at the same price through a new website launching in January [5]. Group 2: Competitive Landscape - Eli Lilly, a major competitor, is also developing an oral weight loss drug and has submitted it for FDA approval, which is expected to follow shortly after Novo Nordisk's approval [7]. - Eli Lilly's injectable weight loss drugs use tirzepatide, while its oral formulation is based on a new ingredient, orforglipron [7]. - Recent performance shows Eli Lilly's Zepbound has surpassed Novo Nordisk's Wegovy in revenue contribution [8]. Group 3: Drug Efficacy and Development - Novo Nordisk's oral drug includes a protective component, SNAC, to prevent rapid degradation in the stomach, requiring patients to take it on an empty stomach [11]. - Clinical studies indicate that Novo Nordisk's oral formulation achieves weight loss comparable to its injectable version over 64 weeks, while Eli Lilly's oral drug shows less efficacy compared to its injectable [11]. - Both companies are exploring next-generation drugs, with Novo Nordisk researching cagrilintide and Eli Lilly focusing on retatrutide, which may offer enhanced weight loss and metabolic benefits [12]. Group 4: Market Impact and Stock Performance - Following the approval of the oral weight loss drug, Novo Nordisk's stock rose by 7.30%, reaching a market capitalization of $175 billion, although it has seen a year-to-date decline of 38.35% [14]. - Eli Lilly's stock has increased by 39.54% year-to-date, reflecting strong market confidence in its weight loss products [14]. - Pfizer has entered the weight loss drug market by acquiring Metsera for approximately $100 billion, aiming to develop a monthly injectable GLP-1 receptor agonist [13][14].

The pill is 25 milligrams of semaglutide, the same active ingredient in injectable Wegovy and Ozempic, and will be sold under the brand name Wegovy. Novo already sells an oral semaglutide for type 2 diabetes, Rybelsus. The U.S. Food and Drug Administration approved Novo Nordisk's weight-loss pill on Monday, giving the Danish drugmaker a leg up in the race to market a potent oral medication for shedding pounds as it looks to regain lost ground from rival Eli Lilly. The approval could help spur a turnaround f ...

Key Takeaways NVO leans on GLP-1 leadership, with Ozempic, Wegovy and Rybelsus driving growth but facing rising competition.AMGN benefits from diversification, with oncology, rare disease, biosimilars, and obesity studies underway.NVO shares fell sharply over six months, while AMGN stock gained as earnings estimates trended higher.Both Novo Nordisk (NVO) and Amgen (AMGN) are large-cap, innovation-driven healthcare leaders with global scale, strong balance sheets, and a track record of turning scientific bre ...

Core Viewpoint - The approval of the first oral GLP-1 weight loss medication, Wegovy, by the U.S. regulatory authorities marks the beginning of a new era in obesity treatment, with potential for further expansion in this category [1]. Group 1: Company Developments - Following the announcement, the stock of Novo Nordisk rose approximately 10% in after-hours trading, ultimately closing with a gain of 9.5% [2]. - The approval is a significant victory for Novo Nordisk, which has faced intense competition from Eli Lilly in the weight loss drug market, leading to pressure on its stock earlier in the year [3]. - Novo Nordisk plans to launch the new oral medication in early January at a cash price of $149 per month, with potential costs as low as $25 per month for insured patients [4]. Group 2: Clinical and Market Insights - The oral medication contains 25 mg of semaglutide, the same active ingredient found in the injectable versions of Wegovy and Ozempic, and is expected to provide significant weight loss results [4]. - Clinical trial results from the Oasis 4 study indicated that patients taking the 25 mg dose lost an average of approximately 16.6% of their body weight over 64 weeks, supporting the drug's efficacy [4]. - The FDA approval also allows the drug to be used for reducing the risk of major cardiovascular events in adults with obesity and diagnosed cardiovascular disease [4]. Group 3: Competitive Landscape - Analysts note that the approval of the GLP-1 weight loss pill is a much-needed win for Novo Nordisk amid challenges to maintain its market share in the incretin market [5]. - Earlier this year, Eli Lilly captured a significant market share with its injection drug Zepbound, which has been shown to be more effective than Novo Nordisk's Wegovy [6]. - The market for weight loss drugs is expected to grow significantly, with Goldman Sachs analysts projecting that by 2030, weight loss medications could account for 24% of the global weight loss drug market, approximately $22 billion [6].

在经历了股价下滑、盈利预警、注射类药物Wegovy销售放缓、来自礼来的激烈竞争和复方药的压力等 动荡的一年之后，此次批准可能有助于诺和诺德扭转局面。 获批消息公布后，诺和诺德在美国上市的股票在盘后交易中上涨了6%。 一项为期64周的晚期研究显示，每天服用一次25毫克口服司美格鲁肽的参与者平均减轻了16.6%的体 重，而服用安慰剂的参与者平均减轻了2.7%的体重。 该药丸被批准用于肥胖或超重且至少有一种相关健康状况的成年人的慢性体重管理，在保险公司、雇主 和政府都在努力应对与肥胖相关的医疗成本不断上升之际，扩大了潜在的患者群体。 来源：环球市场播报 美国食品和药物管理局（FDA）周一批准了诺和诺德的减肥药丸，使这家丹麦制药商有望从竞争对手礼 来（Eli Lilly）手中夺回失地，在推销一种有效的口服减肥药的竞争中占据上风。 这种药丸含有25毫克的司美格鲁肽（semaglutide），与注射用Wegovy和Ozempic中的活性成分相同，并 将以Wegovy的品牌名称销售。目前诺和诺德已经在销售一种治疗2型糖尿病的口服司美格鲁肽药物，名 为Rybelsus。 ...

Core Insights - Eli Lilly's oral weight loss drug orforglipron has shown significant progress in late-stage clinical trials, demonstrating its ability to help patients maintain weight loss after switching from injectable treatments [1][3] - The FDA has received a submission for orforglipron's approval, which could provide a non-injection long-term weight management solution for obesity patients [1] - The oral weight loss drug market is expected to be dominated by Eli Lilly and Novo Nordisk, with Eli Lilly potentially capturing a significant share of the maintenance patient market [2] Clinical Trial Results - The ATTAIN-MAINTAIN phase 3 clinical trial included over 300 obesity patients who previously received 72 weeks of treatment with Wegovy or Zepbound injections, followed by a 52-week observation period after switching to orforglipron or a placebo [3] - The trial met its primary endpoint, showing that orforglipron significantly outperformed the placebo in maintaining weight after the injection treatment plateau, with patients switching from Wegovy regaining an average of only 2 pounds, while those switching from Zepbound regained about 11 pounds [3] Competitive Landscape - Analysts believe the trial results provide Eli Lilly with a unique opportunity to capture revenue from patients who have been on long-term treatment with Novo Nordisk's semaglutide products [4] - Unlike Novo Nordisk's oral medications, orforglipron is not a peptide drug, making it easier for the body to absorb and potentially offering better patient compliance and long-term convenience [4] Safety and Market Share Projections - Safety data for orforglipron aligns with previous studies, with gastrointestinal symptoms being the most common side effects, typically mild to moderate in severity [5] - Discontinuation rates due to side effects were low, with 4.8% for the Wegovy switch group and 7.2% for the Zepbound switch group, compared to 7.6% and 6.3% for the placebo groups, respectively [5] - Goldman Sachs analysts project that the oral weight loss drug market will reach approximately $22 billion by 2030, with orforglipron expected to capture about 60% of this market share [6]