Group 1 - The article highlights the publication of seven papers in the prestigious journal Cell, with six authored by Chinese scholars, indicating a significant contribution to the field of scientific research [3]. - AAVLINK, a new strategy for gene therapy, was developed to overcome delivery size limitations, achieving efficient gene recombination and expression of autism-related gene Shank3 and epilepsy-related gene SCN1A in mouse models [5][7]. - The POCKET device, a flexible bioelectronic patch, was created for precise intracellular delivery, demonstrating high delivery efficiency and spatial control in various organs, which could enhance drug delivery and gene transfection [10][12]. Group 2 - A study revealed a novel GPCR-G protein-β-arrestin megacomplex regulated by a versatile allosteric modulator, which could lead to new therapeutic approaches targeting GPCRs, crucial for many clinical drugs [19][21]. - The research on systemic stomatal immunity in plants identified a mobile peptide that transmits danger signals from infected to uninfected leaves, enhancing plant defense mechanisms against pathogens [25][27]. - An innovative urine liquid biopsy method for bladder cancer was developed, improving specificity by removing field effect mutations, which could guide personalized treatment strategies for non-muscle invasive bladder cancer patients [30][32].

Core Viewpoint - The article discusses the discovery of a novel global immune system in plants called systemic stomatal immunity (SSIM), which allows plants to rapidly respond to pathogen threats by transmitting immune signals from infected to uninfected leaves [3][8]. Group 1: Research Findings - The research identifies a mobile peptide encoded by upstream open reading frames (uORF) that mediates systemic stomatal immunity, termed USIC [5][6]. - Infected local leaves transmit danger signals to distal uninfected leaves, triggering stomatal closure and initiating the SSIM defense mechanism [5][6]. - The peptide USIC is recognized by the SIRK1-KIN7 receptor complex in systemic leaves, leading to a cascade of molecular interactions that regulate stomatal immunity [5][6]. Group 2: Implications - This discovery of SSIM represents a significant advancement in plant immunology, distinguishing it from the slower systemic acquired resistance (SAR) that relies on salicylic acid pathways [8]. - The findings provide a theoretical foundation for developing crops with broad-spectrum and rapid disease resistance traits, potentially enhancing agricultural resilience [8].