Core Viewpoint - The article discusses a significant breakthrough in drug delivery technology, specifically through the development of a flexible, implantable bioelectronic device called POCKET, which allows for precise and efficient drug delivery to complex organ surfaces, addressing long-standing issues in traditional drug delivery methods [2][3]. Research Background - The research originated from a clinical challenge faced by doctors regarding hereditary ovarian gene mutations, where traditional gene therapy methods pose risks to reproductive cells. The team shifted focus to a physical method called electroporation to deliver therapeutic agents safely to ovarian surface cells without affecting the eggs [7]. Breakthrough Innovation - The research team drew inspiration from traditional paper-cutting art to create a "customized organ conformal kirigami theory," establishing a quantitative relationship between geometric parameters of the kirigami structure and the curvature of organs, enabling the design of patches that achieve over 95% coverage on organ surfaces [9]. Device Design and Functionality - The POCKET device features a four-layer functional design, including a nanopore array film for direct tissue contact, a hydrogel drug-loading layer, a silver nanowire electrode layer for electric field distribution, and a flexible substrate layer. This design allows for high conformability and large-area adhesion to various organ surfaces [12]. Efficacy Validation 1: Ovarian Cancer Prevention - In animal models, POCKET successfully delivered functional BRCA1 plasmids to ovarian surface cells, significantly reducing cancer risk without affecting reproductive cells. This approach restored ovarian hormone secretion and fertility, providing a viable alternative to surgical removal for women with cancer risk mutations [15]. Efficacy Validation 2: Organ Damage Repair - In kidney transplant scenarios, POCKET was used to deliver anti-inflammatory drugs locally, showing significant improvement in tubular repair and kidney function while avoiding systemic side effects associated with oral medications, highlighting its advantages in chronic disease management [19]. Technology Translation and Clinical Application - The POCKET platform offers new tools for precise treatment of ovarian cancer prevention and organ damage repair, integrating flexible electronics and micro-nano processing for effective control and long-term operation. The technology has progressed from laboratory to industry, with a high-tech company already established and the first product, Ultra-NEP, applied in skin health [22][24].