司美格鲁肽 作为一种治疗2型糖尿病和长期体重管理的药物， 凭借优秀的 降糖功能和快速的减重效果 这两大标签 ， 它很快就火遍全 球， 被广泛视为"减肥神药 " 。 整理 | GLP1减重宝典内容团队 美国华盛顿大学的胃肠病专家指出，事实上，人体本身就能产生这些药物的 天然版本 ——GLP-1。那究竟 如何促进天然司美格鲁肽生 成，一篇SCI论文给出了答案。 ▍ 天然司美格鲁肽由下肠道产生，可以抑制食欲，减缓胃排空 下肠道中的特殊细菌会吸收你无法消化的食物成分，如纤维和多酚（许多加工食品中去除的植物成分），并将其转化为降低食欲和新陈 代谢的激素分子。这些细菌包括 GLP-1， 这是 Wegovy 和 Ozempic 的天然版本。 GLP-1 和其他激素（如 PYY） 有助于通过胰腺调节血糖。它们还会调节下丘脑神经元告诉您的大脑您已经吃饱了，并让您的胃和肠道 放慢食物沿消化道的移动速度，以便消化。这个系统甚至有一个名字： 结肠制动器。 既然人体能生成天然司美格鲁肽 ， 为什么我们还需要司美格鲁肽等GLP-1类药物？ 这和GLP-1类药物本身的结构不容易降解有关， 且天然司美格鲁肽 是一种由30个氨基酸组成的多肽， ...

Core Viewpoint - Semaglutide and Tirzepatide are breakthrough drugs for weight loss and diabetes management, targeting the underlying pathways of obesity and diabetes [1] Group 1: Mechanism of Action - The body produces natural versions of these drugs, known as incretin hormones, in the gut, which are regulated by nutrients and gut microbiota [2] - Specific bacteria in the lower gut convert indigestible food components into molecules that stimulate appetite and metabolism-controlling hormones like GLP-1, the natural version of Semaglutide [3] - GLP-1 and other hormones help regulate blood sugar through the pancreas and signal the brain about satiety, slowing down food movement in the digestive tract [3][4] Group 2: Impact of Processed Foods - The rise of processed foods has led to the removal of bioactive molecules like fiber and polyphenols, which are essential for regulating metabolic pathways [3] - The loss of these key food components and the resulting decline in gut microbiota diversity may significantly contribute to the increase in obesity and diabetes [6] Group 3: Dietary Recommendations - A healthy lifestyle, including regular exercise, stress management, sleep, outdoor activities, and a balanced diet, is crucial for managing metabolic diseases [5] - Introducing minimally processed foods rich in fiber and polyphenols can enhance GLP-1 levels and address the obesity and metabolic disease epidemic [5] Group 4: Foods that Stimulate GLP-1 Production - Eggs are rich in protein and monounsaturated fats, which can enhance GLP-1 secretion [8] - Nuts like almonds, pistachios, and peanuts may increase GLP-1 levels due to their protein, fiber, and healthy fat content [8] - High-fiber grains such as oats, barley, and whole wheat can stimulate GLP-1 release through soluble fiber and short-chain fatty acids produced during fermentation [9] - Avocados can increase GLP-1 levels due to their high fiber and monounsaturated fat content [9] - Olive oil, rich in unsaturated fats, has been shown to stimulate GLP-1 release more effectively than saturated fats [10] - Vegetables like Brussels sprouts, broccoli, and carrots are beneficial for regulating blood sugar and may influence GLP-1 levels [10]