Core Viewpoint - Semaglutide, a drug for treating type 2 diabetes and long-term weight management, is recognized for its effective blood sugar reduction and rapid weight loss, leading to its popularity as a "weight loss miracle drug" [4]. Group 1: Mechanism of GLP-1 - The human body can produce a natural version of these drugs, known as GLP-1, which is influenced by specific gut bacteria that convert indigestible food components into appetite-reducing hormones [6]. - GLP-1 and other hormones like PYY help regulate blood sugar through the pancreas and signal the brain about satiety, slowing down food movement in the digestive tract [6]. Group 2: Foods that Promote Natural GLP-1 Production - Eggs are rich in protein and monounsaturated fats, which can enhance GLP-1 secretion, leading to lower post-meal blood sugar levels and reduced hunger [8]. - Nuts such as almonds, pistachios, and peanuts may increase GLP-1 levels due to their protein, fiber, and healthy fat content, which also aids in insulin sensitivity [8]. - High-fiber grains like oats, barley, and whole wheat can stimulate GLP-1 release by slowing digestion and producing short-chain fatty acids through fermentation [9]. - Avocados, due to their high fiber and monounsaturated fat content, can also boost GLP-1 levels and improve overall meal satisfaction [10]. - Olive oil, rich in unsaturated fats, has been shown to enhance GLP-1 release compared to saturated fats, improving insulin sensitivity and lowering blood sugar levels [10]. - Vegetables such as Brussels sprouts, broccoli, and carrots are beneficial for regulating blood sugar and may positively influence GLP-1 levels [10]. Group 3: Lifestyle Factors - A healthy lifestyle, including regular exercise, stress management, sleep, outdoor activities, and a balanced diet, is crucial for managing metabolic diseases and overall health [11]. - Incorporating minimally processed foods rich in fiber and polyphenols can significantly support metabolic health and appetite control [11]. Group 4: Potential Side Effects of GLP-1 Drugs - While GLP-1 drugs can be effective for weight loss, they may have side effects such as nausea, vomiting, diarrhea, abdominal pain, and dizziness [12].

Core Viewpoint - Semaglutide and Tirzepatide are breakthrough drugs for weight loss and diabetes management, targeting the underlying pathways of obesity and diabetes [1] Group 1: Mechanism of Action - The body produces natural versions of these drugs, known as incretin hormones, in the gut, which are regulated by nutrients and gut microbiota [2] - Specific bacteria in the lower gut convert indigestible food components into molecules that stimulate appetite and metabolism-controlling hormones like GLP-1, the natural version of Semaglutide [3] - GLP-1 and other hormones help regulate blood sugar through the pancreas and signal the brain about satiety, slowing down food movement in the digestive tract [3][4] Group 2: Impact of Processed Foods - The rise of processed foods has led to the removal of bioactive molecules like fiber and polyphenols, which are essential for regulating metabolic pathways [3] - The loss of these key food components and the resulting decline in gut microbiota diversity may significantly contribute to the increase in obesity and diabetes [6] Group 3: Dietary Recommendations - A healthy lifestyle, including regular exercise, stress management, sleep, outdoor activities, and a balanced diet, is crucial for managing metabolic diseases [5] - Introducing minimally processed foods rich in fiber and polyphenols can enhance GLP-1 levels and address the obesity and metabolic disease epidemic [5] Group 4: Foods that Stimulate GLP-1 Production - Eggs are rich in protein and monounsaturated fats, which can enhance GLP-1 secretion [8] - Nuts like almonds, pistachios, and peanuts may increase GLP-1 levels due to their protein, fiber, and healthy fat content [8] - High-fiber grains such as oats, barley, and whole wheat can stimulate GLP-1 release through soluble fiber and short-chain fatty acids produced during fermentation [9] - Avocados can increase GLP-1 levels due to their high fiber and monounsaturated fat content [9] - Olive oil, rich in unsaturated fats, has been shown to stimulate GLP-1 release more effectively than saturated fats [10] - Vegetables like Brussels sprouts, broccoli, and carrots are beneficial for regulating blood sugar and may influence GLP-1 levels [10]