Core Viewpoint - Nanjing Valiant BioTech Co., Ltd. is leading in next-generation tumor immunotherapy and has successfully listed on the Hong Kong Stock Exchange, raising up to $189 million through its IPO at a price of HKD 35 per share [1][2][11] Financing and Investment - The IPO attracted cornerstone investors totaling approximately HKD 542 million, including prominent medical funds and long-term institutions such as OrbiMed, TruMed, and domestic public funds like E Fund [2] - The net proceeds from the IPO will be allocated as follows: approximately 65% for clinical development, 15% for preclinical assets and pipeline expansion, 10% for production capacity enhancement, and 10% for working capital and general corporate purposes [2] Company Overview - Established in 2012, the company focuses on discovering, developing, and commercializing new therapies for cancer, autoimmune diseases, and other major diseases [3][10] - The company has developed a diverse product portfolio with 14 innovative candidates, of which 6 are in clinical stages and 4 are leading globally in clinical progress [11] Product Pipeline - The core product LBL-024 is a PD-L1 and 4-1BB bispecific antibody, currently in registration clinical stage, and is the first targeted therapy for the 4-1BB receptor [3][11] - The company has a total of 12 products in its tumor pipeline, including 3 monoclonal antibodies, 5 bispecific antibodies, and 3 antibody-drug conjugates (ADCs) [3] Technological Innovation - The company employs a science-driven R&D approach and has developed proprietary technology platforms such as LeadsBody™ and X-body™ for innovative drug development [4][12] - The LeadsBody™ platform supports the development of bispecific antibodies targeting CD3, optimizing efficacy and safety by minimizing systemic toxicity [4][12] Clinical Development - The company has established comprehensive capabilities across early research, translational medicine, clinical development, and business expansion, enabling efficient drug development processes [10][12] - The company aims to become a comprehensive biotechnology firm, with plans to establish commercial-scale production facilities as clinical assets approach commercialization [10]

Core Viewpoint - The successful IPO of Nanjing Weilizhibo Biotech Co., Ltd. has injected confidence into the biotech sector for future listings in Hong Kong, showcasing strong market performance and investor interest [2][4]. Company Overview - Weilizhibo, established in 2012, focuses on discovering, developing, and commercializing new therapies for cancer and autoimmune diseases, with a strategic emphasis on tumor immunology, T-cell engagers, and antibody-drug conjugates [5]. - The company has a diverse product portfolio with 14 innovative candidates, including 4 core products that are leading in global clinical progress [5]. IPO Details - Weilizhibo's IPO on July 25, 2025, involved the issuance of 36,862,500 H-shares at an offering price of HKD 35.00 per share, raising a total of HKD 1.29 billion [2]. - The company attracted 9 cornerstone investors, collectively subscribing USD 69 million (approximately HKD 541.6 million) [2]. Market Performance - As of 9:50 AM on the listing day, Weilizhibo's share price reached HKD 77.65, reflecting a 121.86% increase from the offering price, with a market capitalization of HKD 14.986 billion [3]. Product Pipeline - The core product LBL-024 is a pioneering dual-specific antibody targeting PD-L1/4-1BB, which has entered the registration clinical stage and is recognized as a breakthrough therapy for neuroendocrine carcinoma by NMPA and granted orphan drug status by the FDA [6]. - LBL-024 is being studied for various cancers, including small cell lung cancer and ovarian cancer, showing promising initial efficacy signals [7]. T-cell Engager Products - Weilizhibo has developed a matrix of 6 differentiated T-cell engager products targeting hematological malignancies, solid tumors, and autoimmune diseases, with several candidates already in clinical research [8]. Use of IPO Proceeds - Approximately 65% of the net proceeds from the IPO will be allocated to clinical development and regulatory affairs for ongoing and planned candidates, while 15% will enhance preclinical assets and expand existing pipelines [9].

Core Viewpoint - Nanjing Weilizhibo Biotechnology Co., Ltd. officially listed on the Hong Kong Stock Exchange on July 25, 2025, with an IPO price of HKD 35 per share, aiming to raise approximately USD 189 million for clinical development and operational enhancements [1][2]. Company Overview - Founded in 2012, Weilizhibo is a clinical-stage biotechnology company focused on discovering, developing, and commercializing new therapies for cancer, autoimmune diseases, and other major diseases [2]. - The company has a diverse product portfolio with 14 innovative candidates, including 4 core products, all of which are leading in global clinical progress within their respective categories [2]. Business Model and Technology Platforms - Weilizhibo's core business model emphasizes self-discovery, development, and commercialization of tumor immunotherapies, focusing on three main areas: IO 2.0, T-cell engagers (TCE), and antibody-drug conjugates (ADC) [2][4]. - The company has developed proprietary technology platforms, including LeadsBody™ and X-body™, which support the development of bispecific antibodies and enhance therapeutic efficacy while minimizing systemic toxicity [4]. Clinical Pipeline and Research Highlights - The company has established a robust pipeline with 12 products targeting tumors, including 3 monoclonal antibodies, 5 bispecific antibodies, and 3 ADCs [2][4]. - LBL-024, a bispecific antibody targeting PD-L1 and 4-1BB, has shown promising results in clinical trials for treating advanced pulmonary neuroendocrine carcinoma, achieving an objective response rate (ORR) of 75% and a disease control rate (DCR) of 92.3% [7][8]. - LBL-024 is the first targeted therapy for the 4-1BB receptor in the registration clinical stage, with potential applications across various cancers, including small cell lung cancer and ovarian cancer [8][10]. Funding Utilization - The proceeds from the IPO will be allocated as follows: approximately 65% for clinical development and regulatory affairs, 15% for enhancing preclinical assets and expanding the pipeline, 10% for capacity enhancement and commercialization, and 10% for working capital and general corporate purposes [1].

Core Viewpoint - The Hong Kong IPO market has experienced its strongest recovery in nearly a decade, with significant increases in both the number of IPOs and the quality of listed companies, driven by improved liquidity, optimized listing regulations, and restored investor confidence [1] Company Overview - Weili Zhibo, known as "China's TCE first stock," is set to officially list on the Hong Kong Stock Exchange on July 25, 2025, with a global offering of approximately 36.86 million shares at a price of HKD 35 per share [1] - The company has attracted significant interest from top-tier domestic and international pharmaceutical investment institutions, with a retail subscription rate of 3,494.8 times, setting a record for the Hong Kong 18A medical innovation sector [1] Market Potential - The global tumor immunotherapy market is projected to reach USD 97.1 billion by 2025, with a compound annual growth rate (CAGR) of 17.3%, potentially growing to USD 216 billion by 2030 [2] - The TCE (T-cell engagers) market is expected to reach CNY 8.3 billion by 2030, with a CAGR of 67.4% from 2024 to 2030, indicating a vast market opportunity [5] Product Pipeline - Weili Zhibo has developed a diverse pipeline of 14 candidate drugs, including monoclonal antibodies, bispecific antibodies, antibody-drug conjugates (ADCs), and others, with six candidates already in clinical stages [3][4] - The company's core product, LBL-034, has shown promising clinical results, with an objective response rate of 77.8% in trials for relapsed/refractory multiple myeloma [6] Innovation Strategy - The company employs a differentiated innovation strategy focusing on T-cell connectors (TCE), tumor immunotherapy 2.0 (IO 2.0), and ADCs, establishing a globally competitive research and development pipeline [3][11] - LBL-024, a key product in the IO 2.0 field, is the first and only 4-1BB antibody drug to enter the registration clinical stage, targeting various cancers with significant unmet medical needs [9][10] Competitive Advantage - Weili Zhibo's unique technology integration allows it to provide comprehensive solutions for different tumor types, enhancing its ability to address complex clinical challenges [11] - The company's strategic focus on innovation positions it to capitalize on the growing demand for effective cancer treatments, potentially leading to substantial market value growth [12]