Core Insights - The Zibo Maternal and Child Health Hospital has established itself as a benchmark institution in the field of prenatal diagnosis, achieving an annual outpatient volume of 20,000 and reducing the birth defect rate in Zibo to 1.7% over 20 years [1][12] Group 1: Institutional Achievements - The center has been recognized as the Zibo Prenatal Screening and Diagnosis Quality Control Center and the Zibo Comprehensive Intervention Center for Birth Defects, contributing to a comprehensive three-tier prevention system covering pre-pregnancy, prenatal, and neonatal stages [1] - The center has served over 400,000 outpatient visits, providing critical support for families in Zibo and surrounding areas [1] Group 2: Technological Advancements - The center employs advanced technologies such as high-throughput sequencing capable of detecting millions of genetic loci and minimally invasive procedures like chorionic villus sampling [8] - It has developed a full-cycle diagnostic and intervention system that includes prenatal precision diagnosis, intrauterine minimally invasive interventions, and long-term follow-up management [13] Group 3: Impact on Birth Defects - Since participating in the "Government Livelihood Project" in 2021, the center has provided free screening services to over 70,000 pregnant women, achieving a 100% diagnosis and intervention rate for high-risk pregnancies [9] - The center has completed 11,948 prenatal diagnoses, identifying 807 cases of chromosomal abnormalities and 103 cases of single-gene diseases [9] Group 4: Community Engagement and Education - The center conducts regular training for medical personnel, averaging 300 participants annually, and promotes public awareness of prenatal health through community outreach programs [14] - It has successfully integrated social benefits with medical care, enhancing public awareness of healthy childbirth practices [15]

Group 1 - The Capital Medical University Affiliated Capital Children's Medical Center has established a Fetal Medicine Center to provide timely and accurate neonatal surgical assessments for pregnant women with fetal deformities, aiming to avoid unnecessary pregnancy terminations and determine the optimal timing and method for delivery [1][2] - Birth defects are a leading cause of early miscarriage, stillbirth, perinatal mortality, infant mortality, and congenital disabilities, ranking second in causes of death in China, with approximately 800,000 to 1,200,000 new cases each year [1][2] - The Fetal Medicine Center integrates multiple specialties, including neonatal surgery, neurosurgery, ultrasound imaging, genetic medicine, neonatal internal medicine, and urology, and collaborates with various prenatal diagnosis centers across Beijing and nationwide [2] Group 2 - Between 2018 and 2022, 93.69% of live births with congenital diaphragmatic hernia in Beijing were evaluated prenatally and treated by the neonatal surgical team at the Capital Children's Medical Center, with a significantly lower mortality rate of 15.38% compared to 42.86% at other institutions in Beijing [2] - The survival rate for diaphragmatic hernia infants in Beijing reached 80.82%, with the Capital Children's Medical Center achieving a survival rate of 84.62%, surpassing international rates of 75% in the UK and 74.2% in the US [2] - The Fetal Medicine Center aims to shift the focus from postnatal treatment to prenatal intervention, utilizing advanced minimally invasive techniques to treat life-threatening fetal conditions and optimize opportunities for further treatment after birth [2]