随着研究人员开发出更多基于血液的生物标志物，该领域将能够更好地利用这些工具，并提供更多关于 大脑健康状况的信息。 近日，一项发表在《自然》杂志的来自挪威的研究显示，在70岁以上的人群中，阿尔茨海默病的患病率 接近十分之一；在85岁以上人群中，这一比例更是高达25%。 这项最新发表的研究显示，约19%的失智症患者血液中的pTau217水平较低，这表明他们的认知问题是 由其他原因引起的。 加州大学旧金山分校的神经学家Gil Rabinovici评论称，许多认知障碍患者同时患有阿尔茨海默病和其他 形式的失智症。随着研究人员开发出更多基于血液的生物标志物，该领域将能够更好地利用这些工具， 并提供更多关于大脑健康状况的信息。 阿尔茨海默病是一种进行性中枢神经系统神经退行性疾病，通常在晚年或晚年早期阶段发病，特征是认 知和行为能力逐渐恶化。据国际阿尔茨海默病协会发布的一份《2024年阿尔茨海默病事实与数据》报 告，阿尔茨海默病占全球所有痴呆症病例的60%至80%。 复旦大学附属华山医院神经内科主任医师郁金泰教授告诉第一财经记者，阿尔茨海默病血液检测可以与 其他的检测方法结合使用，可以作为疾病大规模早期筛查及持续监测的一种 ...

Core Insights - An international study involving the Karolinska Institute in Sweden has identified a set of common blood biomarkers that are closely related to the risk of "multimorbidity" and the accumulation of diseases in the elderly [1][2] - The research analyzed the health status of over 2,200 individuals aged 60 and above in Stockholm over a period of 15 years, revealing that 7 out of 54 biomarkers were associated with multimorbidity [1] - The findings suggest that future blood tests could help doctors identify at-risk populations for early health management and intervention [2] Group 1 - The study found that biomarkers such as growth differentiation factor 15, glycated hemoglobin, cystatin C, leptin, and insulin are related to the overall burden of chronic diseases and common disease combinations [1] - Gamma-glutamyl transferase and albumin were primarily associated with the speed of disease progression [1] - The research also validated its findings using health data from 522 individuals in the U.S., which yielded consistent results [1] Group 2 - The researchers emphasized that the findings reveal statistical correlations rather than direct causation of multimorbidity by specific biomarkers [1] - The study indicates that metabolic disorders, stress responses, and energy regulation abnormalities may be significant biological factors driving the occurrence and development of multimorbidity in the elderly [1] - Future research will track how these blood biomarkers change over time and whether lifestyle or medication can influence the related pathological processes [2]