Core Insights - The company has received approval from the National Medical Products Administration of China for its product "Mebsartan Potassium Tablets" (trademark: Kuanopeng), which is indicated for the treatment of primary hypertension [1][2] - "Mebsartan Potassium" is a significant addition to the company's product pipeline in the cardiovascular system sector, providing more treatment options for adult patients with primary hypertension [2] Group 1: Product Details - "Mebsartan Potassium" is an angiotensin II receptor antagonist that converts rapidly to its active form, Azilsartan, after oral administration, effectively lowering blood pressure by blocking angiotensin II hormone [1] - The product is classified as a Category B drug by the National Medical Insurance Administration, with no restrictions on insurance indications or disease types, making it a first-line antihypertensive medication for adults [1] Group 2: Market Context - The "sartan" class of antihypertensive drugs holds over 80% market share in the overall renin-angiotensin system (RAS) market, with sales exceeding 10 billion RMB in 2022, highlighting its importance in the hypertension drug family [1] - The company’s "Mebsartan Potassium Tablets" are available in 40mg and 80mg dosages, catering to both mild to moderate and severe hypertension patients [2]

在整体肾素—血管紧张素系统(RAS)市场中，有超过80%的份额被"沙坦"类单一及各类联合疗法用药占 据，2022年销售额超100亿元人民币，"沙坦"类降压药在整个高血压药物家族中占据重要位置。 "美阿沙坦钾片"的主要成分美阿沙坦钾属于血管紧张素II受体拮抗剂，口服吸收后迅速转化为活性成分 阿齐沙坦，可通过阻断血管紧张素II荷尔蒙而起到降压的作用。 "美阿沙坦钾片"是国家医疗保障局乙类药物，且无医保适应症及病种限制，目前已成为国内外治疗成人 原发性高血压的一线降压药物。其具有降压效果显著;降压作用持久、稳定;器官保护作用更强等优势。 我公司开发的"美阿沙坦钾片"，与原研剂型一致，通过药学和临床(BE)研究达到其品质和疗效与参比制 剂一致，保障患者用药安全、有效，风险—获益比与参比制剂相当。 福森药业(01652)发布公告，本集团的全资附属公司嘉亨(珠海横琴)医药科技有限公司研发的"美阿沙坦 钾片"(商标：快诺平)，上市申请已获得中国国家药品监督管理局批准，批准用于原发性高血压的治 疗。 "美阿沙坦钾片"是本集团又一重要产品，进一步丰富了本集团在血液循环系统领域的医疗产品管线。 40mg和80mg两种规格，可分别 ...

Core Viewpoint - The approval of Azilsartan by the National Medical Products Administration of China marks a significant milestone for the company, allowing it to be used as an active pharmaceutical ingredient in marketed formulations [1] Company Summary - The company, Stone Four Pharmaceutical Group, has received regulatory approval for Azilsartan, which is classified as an angiotensin II receptor blocker (ARB) [1] - Azilsartan is primarily indicated for the treatment of hypertension by blocking the effects of angiotensin II to lower blood pressure [1]

自願公告 產品開發的最新進展 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不會就因本公告全部或任何部份內容而產生 或因倚賴該等內容而引致之任何損失承擔任何責任。 本公告為本公司自願發佈，目的是使股東及潛在投資者瞭解本集團最新業務發展情況。 承董事局命 執行董事兼公司秘書 周興揚 香港，二零二五年八月十四日 於本公告日期，董事局成員包括執行董事曲繼廣先生、蘇學軍先生、孟國先生、周興揚先生及 曲婉蓉女士，非執行董事劉文軍先生，以及獨立非執行董事王亦兵先生、周國偉先生及姜廣策 先生。 石四藥集團有限公司（「本公司」，連同其附屬公司，「本集團」）董事局（「董事局」）欣然公告， 本集團的阿齊沙坦已獲中國國家藥品監督管理局批准登記成為在上市製劑使用的原料藥。阿齊 沙坦是一種血管緊張素 II 受體拮抗劑（ARB），通過阻斷血管緊張素 II 的作用而降低血壓，主 要用於治療高血壓。 ...