Core Viewpoint - The article discusses a breakthrough in hydrogel technology developed by researchers at East China University of Science and Technology, which features a self-repairing gel that can revolutionize precision medicine through its unique ion-responsive properties [1][3][8]. Group 1: Scientific Discovery - The gel was initially thought to be a failed experiment when it disintegrated but surprisingly reformed itself the next day, leading to the discovery of its self-repairing capabilities [1][4]. - The research team identified the Hofmeister effect as the key scientific principle behind the gel's behavior, which involves specific ions affecting the arrangement of water molecules and thus the solubility of biological macromolecules [4][6]. - This discovery combines a century-old theory with modern dynamic self-assembly techniques, resulting in a supramolecular hydrogel capable of transitioning between gel and liquid states based on ionic conditions [6][8]. Group 2: Medical Applications - The ion-responsive gel addresses significant issues in traditional drug delivery systems, which often result in ineffective treatment due to either premature drug release or inability to deliver large molecules [8][11]. - The gel's mechanism allows for precise drug delivery by disintegrating in response to ion concentration changes, ensuring that medication is released directly at the target site [9][11]. - Its biocompatibility is enhanced compared to traditional covalently cross-linked hydrogels, allowing for minimally invasive treatments and easy clearance from the body post-application [11][12]. Group 3: Market Potential - The hydrogel technology has broader applications beyond drug delivery, including potential uses as ion sensors for monitoring specific ion concentrations in the body, which could lead to early disease detection [12][15]. - The Chinese hydrogel market is projected to reach approximately $4 billion by 2024, with expectations for further growth as smart materials become more prevalent [15][17]. - The research has garnered international attention, with publications in prestigious journals, indicating a strong interest in the technology within the academic and commercial sectors [15][17].

Core Viewpoint - Jiangnan Huanyi is a high-end synthetic biotechnology skincare and cosmetic company focusing on the development and production of innovative materials, particularly supermolecular elastic proteins, which aim to revolutionize the skincare industry by providing multifunctional, high-activity, and green manufacturing solutions [3]. Company Overview - Jiangnan Huanyi Biotech (Changzhou, Jiangsu) is an innovative enterprise that integrates synthetic biology, supramolecular chemistry, nanotechnology, and protein materials science [3]. - The company has developed the world's first high-purity (≥95%) supermolecular elastic protein, addressing industry challenges related to the insufficient functionality of small molecules and absorption limitations of large molecules [3]. - Jiangnan Huanyi holds four national invention patents covering protein purification, supramolecular structure design, functionalization, and green fermentation systems [3]. Product Details - The core product, the "supermolecular elastic protein" gel, is designed specifically for skin elasticity enhancement, combining the benefits of hyaluronic acid, collagen, mussel protein, and natural elastic protein [5]. - The product features include anti-wrinkle properties, improvement of skin elasticity, tightening, wrinkle reduction, and deep hydration [5]. - The theoretical annual production capacity of the product is 10,000 boxes, priced at 400 yuan per box [5]. Industrial Collaboration - Jiangnan Huanyi has partnered with Tongkang Youdao Supply Chain (Guangzhou) Co., Ltd. to utilize its 35 GMPC standardized production lines, which have an annual capacity of 400 million units, ensuring high-quality packaging services for the supermolecular elastic protein gel [6]. - The collaboration aims to create a sustainable and efficient industrial chain, enhancing market promotion and supply capabilities [6]. - Additionally, Jiangnan Huanyi is working with Yangzhong Jiao Cheng Biotechnology Research Co., Ltd. to establish a dedicated strain expression system for the industrial production of supermolecular elastic proteins [6]. Industry Platform - Jiangnan Huanyi has joined the global bio-based and bio-manufacturing industry service platform, bio-basedlink, which aims to provide efficient supplier matching services across various sectors, including materials, energy, and synthetic biology [2][7].