以往，超声神经调控技术主要被用在功能性脑部疾病的治疗中。此次，研究团队探索将其用在脑部恶性 程度最高的胶质母细胞瘤的治疗中。胶质母细胞瘤的恶性程度非常高，在脑部恶性肿瘤中占比约三成。 总体而言，患者生存时间在16个月左右。据悉，以往胶质母细胞瘤的治疗用的是化学方法，效果都不理 想，因为血脑屏障阻碍了药物进入大脑。 研究团队尝试采用物理方法——以超声作为技术媒介，打开血脑屏障进而提高药物入脑的浓度。史之峰 教授解释，超声波本身十分安全，因此可以用在孕产妇的产前检查。在此次研发中，研究团队克服了诸 多技术难点，以确保在最大安全程度下为患者实施最有效的脑肿瘤治疗。 血脑屏障是大脑的保护层，阻止有害物质和细菌进入大脑，在保护人类中枢神经系统的同时，也阻碍了 不少脑部疾病的有效治疗。如何安全打开血脑屏障实现更为有效的治疗，而后顺利闭合血脑屏障，是医 学界致力攻克的难题。 近日，在国家重点研发计划项目：《面向脑肿瘤诊疗一体化的超声脑机植入系统技术研究及样机研制》 启动会上，复旦大学联合华山医院神经外科共同发布了最新研究成果：利用中国自主研制的超声诊疗一 体化装置（UltraBrainPad），专家采用超声神经调控技术，成 ...

Core Viewpoint - The article discusses a breakthrough in medical technology that allows for the safe opening and closing of the blood-brain barrier (BBB) using an ultrasound device called UltraBrainPad, which enhances drug delivery for treating glioblastoma patients [1][2]. Group 1: Technology and Methodology - The UltraBrainPad device enables real-time observation of the brain using a handheld ultrasound probe, allowing doctors to select treatment targets and open the BBB with high precision [2]. - The research team optimized the ultrasound parameters to open the BBB in just 3 minutes, resulting in an average increase of 8 times in drug concentration compared to untreated brain tissue [1][2]. - The technology is described as a "ultrasound brain-machine interface," which not only facilitates drug delivery but also allows for the monitoring and adjustment of brain functions [2][3]. Group 2: Clinical Applications and Future Research - Glioblastoma accounts for approximately 30% of brain tumors, with an average survival time of around 16 months for patients [2]. - Future clinical trials will explore the application of this technology in treating other neurological diseases, including Alzheimer's and Parkinson's disease, as well as various functional neurological disorders [3]. - The research team plans to initiate the "ROAR-BBBO" clinical study to treat recurrent glioblastoma patients, aiming to expand the use of ultrasound brain-machine interface technology beyond drug treatment to include neural regulation and brain-machine integration [3].