撰文丨王聪 编辑丨王多鱼 排版丨水成文 长期以来，我们都知道， 运动学习 涉及神经网络中突触强度的动态调整。突触在反复激活后会增强的活动 依赖性 突触强化 （ Synaptic Potentiation ） 是记忆和技能形成的基本过程。但同样重要的是，大脑必须 要有能力防止这些突触在强化后出现不适当的 突触去强化 （ Synaptic Depotentiation ） ，以确保新获得 的技能得以保留而非丧失。 在 运动学习 （ Motor Learning，指通过 反复练习和经验积累 ，个体逐渐掌握、优化和巩固运动技能的过 程） 期间，控制这种突触强化与突触去强化之间微妙平衡的分子和细胞机制，在很大程度上仍然是个谜。 2025 年 10 月 13 日，深圳湾实验室 甘文标 团队在 Nature 子刊 Nature Neuroscience 上发表了题为 ： Astrocytic Ca 2+ prevents synaptic depotentiation by limiting repetitive activity in dendrites during motor learning 的研究论文。 这项开创 ...

Core Viewpoint - The article highlights the inspiring journey of Lu Yibei, a 50-year-old fitness coach who transitioned from being a full-time mother to a professional trainer, demonstrating that age should not limit one's aspirations and capabilities in pursuing a fulfilling career in fitness [1][9][25]. Group 1: Personal Journey and Transformation - Lu Yibei began her fitness journey eight years ago as a full-time mother, initially seeking to relieve stress through weightlifting [9][10]. - After two years of training, she obtained a national fitness coach certification and started working at a local gym [14]. - Despite being considered a "senior" coach, Lu Yibei maintains impressive fitness metrics, including a body fat percentage of 14.4%, a bench press of 50 kg, and a deadlift of 90 kg [1][8]. Group 2: Teaching Style and Impact - Lu Yibei conducts high-intensity mixed training classes, focusing on detailed instruction and adapting to the varying levels of her students [2][4]. - She has built a strong rapport with her students, many of whom are women over 30, and provides tailored guidance based on her own experiences [20][22]. - Her dedication to continuous learning and improvement has earned her respect and trust among her clients, as she consistently ranks among the top in her coaching assessments [16][18]. Group 3: Philosophy and Outlook - Lu Yibei believes that age is not a barrier but rather an asset that enriches one's life experiences and perspectives [18][25]. - She emphasizes the importance of strength training as a lifelong practice that can enhance quality of life, regardless of age or gender [24]. - Her story serves as a motivation for others to embrace fitness and pursue their passions without being constrained by societal expectations related to age [19][25].