Group 1 - The core viewpoint emphasizes the significant relationship between obesity and various types of cancer, urging the importance of weight management for cancer prevention [1][2][3] - Obesity is defined as excessive fat accumulation leading to weight beyond the normal range, which increases the risk of not only metabolic diseases but also cancer [2] - The International Agency for Research on Cancer (IARC) identifies a correlation between obesity and the risk of 13 types of cancer, including breast, colorectal, pancreatic, and endometrial cancers [2] Group 2 - The relationship between obesity and cancer involves complex biological mechanisms, including hormonal imbalances and chronic inflammation, which create an environment conducive to cancer cell growth [3][4] - Obesity leads to increased levels of inflammatory markers such as TNF-α and IL-6, which can accelerate tumor cell proliferation and metastasis [3] - Elevated estrogen levels due to obesity are linked to the development of breast and endometrial cancers, with postmenopausal women experiencing a significant increase in estrogen production from fat cells [4] Group 3 - Obesity is associated with various cancers, including colorectal cancer, where chronic inflammation and metabolic abnormalities are key risk factors [6] - The risk of breast cancer is notably higher in obese postmenopausal women, with obesity contributing to poorer prognosis and treatment response [6] - Obesity is a significant risk factor for liver and pancreatic cancers, often linked to insulin resistance and chronic inflammation [6] Group 4 - Effective weight management through diet and exercise is crucial for reducing cancer risk, with recommendations for a balanced diet low in calories, trans fats, and refined sugars [8][9] - Regular physical activity is essential, with guidelines suggesting at least 150 minutes of moderate-intensity aerobic exercise weekly to improve metabolic function and reduce inflammation [10] - Lifestyle adjustments, including smoking cessation and alcohol moderation, are recommended to further mitigate cancer risk [11]