Core Viewpoint - The study reveals that genetic-nutrition interactions control diurnal enhancer-promoter dynamics and liver lipid metabolism, highlighting the importance of genetic and environmental factors in metabolic processes [3][5]. Group 1 - Genetic variations lead to differences in the circadian patterns of gene expression in the liver of humans and mice [4]. - Nutritional challenges alter the rhythmic expression of liver genes in a strain-specific manner [4]. - Over 80% of rhythmic genes and enhancer-promoter interactions are interdependent on genetic and nutritional factors [5]. Group 2 - An atypical clock regulatory factor, estrogen-related receptor gamma (ESRRγ), emerges as a key transcription factor in the study [4]. - Knockout of the Esrrγ gene in mice eliminates strain-specific metabolic responses to diet [4]. - Single nucleotide polymorphisms (SNPs) associated with rhythmic gene expression are enriched in enhancer-promoter interactions and correlate with lipid metabolism characteristics in humans [6]. Group 3 - The findings emphasize the previously underappreciated temporal dimension of genetic-environment interactions in regulating lipid metabolism traits [8]. - The research has significant implications for understanding individual differences in susceptibility to obesity-related diseases and personalized timing therapies [8].