长时程增强(LTP)
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雄性“越胜越勇”,雌性“波澜不惊”,胡海岚团队解析“胜者效应”的性别差异
生物世界· 2025-10-17 04:04
撰文丨王聪 编辑丨王多鱼 排版丨水成文 在生活中,我们常常看到"连胜"现象:一次胜利往往会增加后续获胜的概率。这种被称 为" 胜者效应 " ( winner effect ) 的心理现象,在体育比赛、商业竞争等多个领域都有体现。 以往的研究表明, " 胜者效应 " 在雄性中表现得更为明显。例如,在网球、柔道等竞技项目中,男性运动 员在获胜后,后续比赛获胜的概率会显著提升,女性运动员则没有表现出同样的规律。 然而, " 胜者效应 "的 这种 性别差异 背后的神经机制一直是个谜。 2025 年 10 月 15 日, 浙江大学 胡海岚 教授团队 ( 郑迪 旸 为论文第一作者 ) 在 Cell 子刊 N euron 上 发表题为: Neural mechanism of the sexually dimorphic winner effect in mice 的研究论文。 该研究 解析了 " 胜者效应 "的 性别差异机制 ,雌性小鼠同样具有 "胜者效应",但其强度却显著弱于雄性 小鼠,即表现出 弱 "胜者效应" ,这一性别差异 是由 背内侧前额叶皮层 (dmPFC) 中的一类抑制性神经 元—— 小清蛋白中间神经元 ( ...
布扎基自传:记忆研究的黄金年代,还能再现吗?
Tai Mei Ti A P P· 2025-05-15 04:18
Group 1 - The article discusses the contributions of György Buzsáki to the field of hippocampal research, particularly focusing on neural syntax and the role of inhibitory interneurons in network oscillations [1][3][4] - Buzsáki's research established the concept of feed-forward inhibition, demonstrating how excitatory inputs can activate interneurons before pyramidal cells, thus regulating neuronal activity [9][12][25] - The significance of theta waves, gamma oscillations, and sharp wave-ripple events in memory consolidation and cognitive functions is highlighted, showcasing the interconnectedness of these phenomena [46][49] Group 2 - The historical context of hippocampal research is explored, emphasizing the collaborative nature of scientific discovery and the evolution of key concepts over time [2][3][26] - Buzsáki's journey through various institutions and collaborations with prominent neuroscientists illustrates the importance of interdisciplinary approaches in advancing understanding of neural mechanisms [15][18][34] - The article reflects on the development of terminology in neuroscience, such as "gamma oscillations" and "long-term potentiation," and how these terms have shaped the discourse in the field [37][42]