Group 1 - A French foundation has launched a fundraising lottery to raise public awareness and support for Alzheimer's disease research [1] - Participants can donate 100 euros for a chance to win an original Picasso painting valued at approximately 1 million euros [1] - The lottery offers a total of 120,000 donation opportunities, with the award ceremony scheduled for April 14, 2026, at Christie's auction house in Paris [1] Group 2 - Proceeds from the fundraising event will be donated to the Alzheimer's disease research foundation [1]

Core Viewpoint - A French foundation has launched a fundraising lottery to raise public awareness and support for Alzheimer's disease research, offering a chance to win a Picasso painting valued at approximately €1 million for a €100 donation [1] Group 1: Fundraising Activity - The lottery will provide 120,000 donation opportunities, with the award ceremony scheduled for April 14, 2026, at Christie's auction house in Paris [1] - Proceeds from the event will be donated to the Alzheimer's disease research foundation [1] Group 2: Artwork Details - The featured artwork is a watercolor titled "Head of a Woman," created by Pablo Picasso in 1941, depicting his model Dora Maar [1] - The event has received support from the Picasso family and the foundation [1] Group 3: Previous Events - The organizing body previously held similar lottery events in 2013 and 2020, with winners from Pennsylvania, USA, and Ventimiglia, Italy, respectively [1]

Core Insights - The article discusses the relationship between tau protein and cognitive decline in Alzheimer's disease (AD), highlighting that soluble tau protein, rather than tangles, is closely associated with the clinical progression of AD [2][3][5] - Recent research published in the journal Cell reveals that high-molecular-weight tau protein derived from Alzheimer's patients impairs the bursting activity of hippocampal neurons, indicating a cellular mechanism behind tau-dependent cognitive decline [3][5] Group 1: Research Findings - The study confirms that tau protein selectively weakens the complex bursting activity of CA1 neurons in the hippocampus, which is essential for learning and memory [5] - Impairment of bursting activity is linked to changes in hippocampal network activity, associated with theta rhythms and high-frequency ripple waves, along with a reduction in CaV2.3 calcium channel expression [5] - The research identifies soluble high-molecular-weight tau protein as a key subtype that inhibits bursting activity, suggesting it as a potential therapeutic target for Alzheimer's disease [5] Group 2: Upcoming Events - An online lecture titled "Tau's Structure, Modification, and Pathogenicity: Breakthroughs in Diagnosis and Treatment of Neurodegenerative Diseases" will be held on September 18, focusing on tau protein's dual role in neurons and neurodegenerative diseases [8]