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髓系细胞衔接器(MCE)
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科望医药港股招股书更新:冲刺MCE第一股 多家明星资本“护航”
Zheng Quan Ri Bao Wang· 2025-11-26 07:15
Core Insights - The article discusses the updated prospectus of Kewang Pharmaceutical Group, which is primarily focused on developing innovative therapies for cancer and autoimmune diseases through a novel technology called Myeloid Cell Engager (MCE) [1][2]. Company Overview - Kewang Pharmaceutical was established in 2017 and is a research-driven clinical-stage biopharmaceutical company [1]. - The company aims to regulate immune cells to treat tumors and autoimmune diseases, positioning itself as the first company to utilize MCE technology in this field [1]. Technology and Product Pipeline - Kewang Pharmaceutical's MCE technology employs bispecific antibodies to modulate myeloid cells, such as macrophages, for therapeutic effects [1]. - The company has three products in clinical development for cancer treatment, with ES102 targeting OX40 currently in Phase II trials in China, aimed at patients with non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) [2]. - ES104 is the only clinical-stage VEGF/DLL4 bispecific antibody in China, showing anti-tumor activity across various cancer types [3]. - ES014 is a globally pioneering CD39/TGFβ bispecific antibody, expected to treat NSCLC and other tumors [3]. Market Context - Major pharmaceutical companies like Novartis, Sanofi, and Eli Lilly are also investing in the MCE space, indicating a growing interest in this therapeutic approach [2]. - Kewang Pharmaceutical has attracted investments from prominent firms such as Hillhouse Capital and Tencent Investment, reflecting confidence in its technology and market potential [2]. Leadership Team - The founding team of Kewang Pharmaceutical has over 25 years of experience in the biopharmaceutical industry, with backgrounds in leading companies like Roche and Bayer [4].