据英国《自然》杂志网站报道，加拿大麦吉尔大学研究团队开发出迄今世界最小尺寸的3D打印 机，配备的打印头仅2.7毫米宽，安装在一个细长的柔性机械臂末端。机械臂的运动方式类似于大象的 鼻子，可通过手术用内窥镜手动控制将水凝胶精准沉积到用于手术训练的人造声带上。 目前，经过培训的操作人员使用控制器手动控制这一设备，但研究人员希望未来能对这款生物打印 机编程，使其在接收到手术部位的图像后，自主遵循预设的打印路径。 此外，研究人员认为，经过进一步的改进和测试，这一设备在声带修复手术之外也具有多种应用前 景。相关论文已发表在国际期刊《设备》杂志上。 新华社伦敦11月3日电（记者郭爽）受灵活的大象鼻子的启发，加拿大研究人员研发出一款微型3D 生物打印机，可帮助医生在声带手术中精准输送治疗性水凝胶。 患者在接受声带囊肿或增生切除手术后，常因声带瘢痕化变硬而导致发声困难。研究表明，注入能 模拟声带天然结构的水凝胶可有效促进愈合过程，并为新生组织提供支撑。但受限于喉部手术视野，外 科医生始终难以精准投放生物材料。 ...

Core Viewpoint - The OTC2025 forum focuses on the advanced applications of organoids and 3D cell culture, discussing topics such as disease modeling, drug screening, AI-driven organ-on-chip technologies, and quality control in organoid cultivation [1][4]. Group 1: Forum Overview - The forum will take place on July 24-25 in Shanghai, featuring over 50 speakers and more than 800 attendees [1]. - Organized by Shanghai Aoshun Pharmaceutical, Shanghai Bai'ao Tai Pharmaceutical Technology, and Yao Jingtong Bio, with support from various academic and medical institutions [1]. Group 2: Agenda Highlights - The main sessions include discussions on tumor organoid drug sensitivity testing, bone organoids, and AI applications in drug screening [4][5]. - Specific topics include retinal organoid technology, high-throughput analysis of tumor organoids, and the application of organoids in disease modeling and drug screening [5][6][7]. Group 3: Key Participants - Notable speakers include experts from prestigious institutions such as Peking University, Macau University, and various research institutes [5][6][7]. - The forum will also feature discussions on the integration of AI in analyzing large-scale organoid data for personalized drug screening [52]. Group 4: Industry Trends - The forum emphasizes the importance of developing automated cultivation systems to enhance organoid production efficiency and reduce costs [54]. - There is a focus on combining 3D bioprinting and microfluidic technologies to improve the complexity and functionality of organoids [54].

Core Insights - A breakthrough in medical 3D printing has been achieved by a research team from the California Institute of Technology, developing a technology that allows for the in-situ creation of medical implants and customized therapeutic tissues without traditional invasive surgery [1][2] - The new technique, named "Imaging-Guided In-Situ Ultrasound Printing" (DISP), combines focused ultrasound with specially designed "ultrasound ink" to precisely manufacture biomaterials deep within the body, potentially transforming personalized medicine [1][2] Group 1 - The DISP technology utilizes focused ultrasound to trigger a gelation reaction of biological ink, enabling in-situ printing at targeted locations within the body [1] - The "ultrasound ink" consists of biopolymers, imaging contrast agents, and temperature-sensitive liposomes, which can be delivered to deep tissues via injection or catheter [1][2] - An automated ultrasound transducer operates according to a pre-set digital model, generating localized micro-heating to release cross-linking agents, leading to rapid gelation of the ink [1][2] Group 2 - The biological ink used in this technology is highly tunable, allowing for the design of properties such as enhanced conductivity, drug release, tissue adhesion, and even real-time imaging capabilities [2] - Successful experiments demonstrated the printing of drug-loaded functional biomaterials near bladder tumors in mice and in deep muscle tissues of rabbits, showcasing DISP's potential in drug delivery, tissue repair, and bioelectronic device construction [2] - Safety assessments indicated that the technology did not cause significant inflammation or tissue damage, and the gel ink is not naturally cleared by the body within a week, indicating good biocompatibility [2] Group 3 - The biomedical field is a significant application area for 3D printing technology, traditionally involving external printing of patient-matched scaffolds before surgical implantation [2] - The DISP technology addresses the limitations of traditional methods by enabling direct in-body printing of biomaterials, potentially alleviating patient discomfort associated with surgeries [2] - Future advancements, including the integration of artificial intelligence for real-time path planning, may revolutionize the traditional model of constructing and implanting 3D printed biomaterials, further advancing personalized medicine [2]