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加科思-B(01167.HK)深度研究报告:PAN-KRAS抑制剂价值重估空间大
Ge Long Hui· 2026-02-26 06:59
Core Insights - The company has successfully launched its first commercial product, the KRAS G12C inhibitor, Goleirese, and is recognized internationally for its research capabilities through collaboration with AstraZeneca on the pan-KRAS inhibitor [1][3] - The company is innovating in the ADC field with tADC and iADC platforms, aiming to overcome traditional treatment limitations and enhance targeted therapies [1][2] Group 1: Product Development - The pan-KRAS inhibitor JAB-23E73 is in collaboration with AstraZeneca, accelerating global development with promising clinical data showing a 10% incidence of grade 1 skin toxicity [1] - The tADC platform, utilizing KRAS inhibitors as payloads, has its first clinical candidate, EGFR G12Di tADC (JAB-BX600), with plans to submit an IND by H2 2026 [1] - The iADC platform aims to deliver STING agonists specifically to tumor cells, with the first candidate HER2-STING iADC (JAB-BX467) also targeting an IND submission by H2 2026 [2] Group 2: Market Expansion - The KRAS G12C inhibitor has received approval for second-line treatment of advanced NSCLC, with further indications being explored, including combination therapies with JAB-3312 [3] - The company has a robust pipeline with multiple undisclosed ADC candidates actively progressing, indicating significant potential for expansion [1][2] Group 3: Financial Outlook - The company has a strong cash reserve, with Goleirese contributing to cash flow, and the collaboration with AstraZeneca expected to enhance global value realization [4] - Projected revenues for 2025-2027 are estimated at 234 million, 627 million, and 508 million yuan, reflecting growth rates of 50.5%, 167.6%, and -19.1% respectively [4] - The company is valued at 8.912 billion HKD, with a target price of 11.26 HKD, indicating a strong buy recommendation [4]