Core Insights - The global GLP-1 market, particularly for weight loss and diabetes management, has seen significant sales growth, but high discontinuation rates among users pose a challenge for sustainable growth [1][5][10] - Novo Nordisk and Eli Lilly, the top producers of GLP-1 drugs, have experienced stock price declines due to lowered performance guidance and disappointing drug development data [1][4][5] - The market for GLP-1 drugs, especially for weight loss, is projected to grow substantially, with estimates suggesting it could reach $1 trillion by 2035 [3][9] Company Performance - Novo Nordisk reported a sales figure of 112.76 billion Danish Krone (approximately $16.6 billion) for its semaglutide in the first half of 2025, surpassing the sales of the cancer drug pembrolizumab [2] - Eli Lilly's tirzepatide achieved sales of $14.73 billion in the same period, marking a significant increase [2][12] - Both companies have faced stock price drops, with Novo Nordisk's stock falling 21.83% in one day after lowering its sales growth forecast [5][12] Market Dynamics - The GLP-1 market is characterized by a high discontinuation rate, with a study showing that 72.2% of patients stopped using GLP-1 drugs within two years [6][7] - The reasons for discontinuation include lack of significant weight loss, side effects, and the achievement of weight loss goals [7][8] - The weight loss segment of the GLP-1 market is expected to account for a significant portion of future sales, with projections indicating it could reach $2.17 trillion by 2031 [9][12] Competitive Landscape - Eli Lilly's tirzepatide is seen as a strong competitor to Novo Nordisk's semaglutide, with sales growth for tirzepatide outpacing that of semaglutide [12][16] - The entry of generic versions of GLP-1 drugs is anticipated, with several companies preparing to launch their versions in the near future [15][16] - The market is becoming increasingly competitive, with over 180 GLP-1 products in development globally, leading to cautious investor sentiment [19][20]