pH依赖性转录凝聚体

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华人学者本周发表5篇Cell论文:AAV替代受体、低碳水饮食促癌、大脑实时指挥血液流动、pH调控炎症反应、甲状腺激素大脑转运
生物世界· 2025-07-19 07:01
Core Insights - The article highlights significant research published in the journal Cell, with a focus on studies led by Chinese scholars, covering various biological mechanisms and their implications for health and disease [2]. Group 1: Adeno-Associated Virus Research - A study identified an alternative receptor for adeno-associated viruses (AAV), named AAVR2, which can restore transduction in the absence of AAVR and provide a unique entry pathway for unclassified AAVs [4][6]. - The research suggests that overexpressing a minimal functional AAVR2 can enhance AAV transduction in vivo, allowing low doses of AAV to achieve similar therapeutic effects [6][8]. Group 2: Glucose Restriction and Tumor Metastasis - Research revealed that glucose restriction influences the pre-metastatic immune landscape in the lungs through exosomal TRAIL, suggesting a new mechanism of immune regulation [10][11]. - The study warns that extreme low-carbohydrate diets may inhibit tumor growth but could also promote lung metastasis, highlighting the need for careful evaluation of metabolic intervention strategies [11][13]. Group 3: Neurovascular Coupling - A study demonstrated that endothelial gap junction coupling enables rapid propagation of vasodilation during neurovascular coupling, crucial for meeting the brain's instantaneous energy demands [15][16]. - The findings indicate that the molecular composition of gap junctions varies along the arterial-venous axis, with the strongest connections found in the arterial segments [16][18]. Group 4: pH-Dependent Inflammatory Responses - Research uncovered how acidic environments during inflammation regulate immune responses through pH-dependent transcriptional condensates, identifying BRD4 condensates as pH sensors [20][21]. - The study suggests that pH acts not only as a byproduct of inflammation but also as an active regulator of the inflammatory response, providing new insights into chronic inflammation and autoimmune diseases [23]. Group 5: Thyroid Hormone Transport Mechanism - A study elucidated the structural mechanisms of thyroid hormone transport via MCT8 and OATP1C1, revealing their binding interactions with active thyroid hormones [25][26]. - The research highlights the importance of these transport mechanisms in development and disease, providing insights into the pathogenic mechanisms of related mutations [28].