Summary of iBio (IBIO) Conference Call - June 24, 2025 Company Overview - **Company**: iBio (IBIO) - **Focus**: Development of next-generation antibody medicines targeting obesity and its cardiometabolic complications [2][28] Industry Context - **Current Treatments**: First-generation GLP-1 receptor agonists and incretin-based therapies have transformed obesity treatment but have limitations, including gastrointestinal side effects and weight regain after discontinuation [3][4][6] - **Market Need**: There is a growing demand for new therapies that can provide durable weight loss, preserve muscle mass, and have better tolerability profiles [6][28] Core Programs and Developments 1. **iBio 600**: - **Type**: Long-acting anti-myostatin inhibitor - **Current Status**: In IND-enabling studies, with GLP toxicology studies about to begin [10][12] - **Mechanism**: Targets myostatin and GDF11, aiming to increase muscle mass and reduce fat mass [13][15] - **Preclinical Results**: In nonhuman primates, a single dose led to an 8% increase in muscle mass and a 12-15% reduction in fat mass [15] - **Projected Half-Life**: 74 to 130 days in humans, allowing for potential biannual dosing [14] 2. **iBio 610**: - **Type**: First-in-class Actin E antibody - **Current Status**: Development candidate selected, testing in nonhuman primates expected to yield data by Q3 2025 [11][19] - **Mechanism**: Promotes fat-specific weight loss without affecting muscle [19][21] - **Preclinical Results**: In obese rodents, led to a 9% reduction in total body weight, with a 26% reduction in fat mass [21] 3. **Amylin Receptor Program**: - **Current Status**: Advanced from early to late discovery, in vivo testing of multiple candidate molecules [23][24] - **Mechanism**: Targets amylin receptors to promote satiety and slow gastric emptying, potentially addressing obesity and cardiometabolic diseases [24][26] - **Unique Approach**: Utilizes AI-driven antibody discovery to create selective agonists for amylin receptor subtypes, avoiding calcitonin receptor activation [26][27] Competitive Advantages - **Integrated AI Platform**: iBio's discovery platform allows for rapid development of antibodies with high specificity and manufacturability [7][29] - **Focus on Developability**: The design process incorporates manufacturability and stability from the outset, ensuring that developed antibodies are ready for clinical use [8][29] - **Strategic Pipeline**: The company has a clear strategy to complement existing therapies and address unmet needs in obesity treatment [9][28] Market Positioning and Future Outlook - **Regulatory Goals**: iBio 600 aims for IND filing in Q1 2026 and patient dosing in Q2 2026 [12][13] - **Potential for Combination Therapies**: iBio's programs are designed to work alongside existing treatments, enhancing efficacy and addressing muscle preservation during weight loss [16][18][22] - **Long-Term Vision**: iBio is positioned to lead in the next wave of obesity therapeutics, focusing on genetically validated targets and innovative treatment strategies [29] Key Takeaways - iBio is addressing significant gaps in current obesity treatments with innovative antibody therapies - The company is leveraging advanced technology and a strategic approach to develop differentiated products - There is a strong emphasis on preclinical data supporting the efficacy and safety of their lead programs, with promising results in animal models [15][21][22]

Summary of First Financial Bancorp (FFBC) Conference Call on Acquisition of Westfield Bancorp Company and Industry - **Company**: First Financial Bancorp (FFBC) - **Acquisition Target**: Westfield Bancorp - **Industry**: Banking and Financial Services Core Points and Arguments 1. **Acquisition Announcement**: FFBC announced the acquisition of Westfield Bancorp from Ohio Farmers Insurance Company, enhancing its presence in the Cleveland, Ohio market [2][3] 2. **Financial Impact**: The acquisition will more than triple FFBC's loan commitments in Northeast Ohio to approximately $1.5 billion and add $1.5 billion in local deposits [3][4] 3. **Branch Network and Talent**: The deal provides FFBC with a highly efficient branch network and talent across multiple business lines, positioning it as a premium alternative to larger banks [3][4] 4. **Earnings Accretion**: The acquisition is financially attractive with strong earnings accretion and a tangible book value earn back within acceptable parameters [4][8] 5. **Asset Quality**: Westfield has a strong record regarding asset quality, with net charge-offs averaging four basis points over the last five years, aligning with FFBC's lending and credit administration approach [5][6] 6. **Market Position**: Post-acquisition, FFBC will become the fourth largest Ohio-based banking company and the only community bank among the top eight banks in the state [6][8] 7. **Transaction Structure**: The transaction is structured as approximately 80% cash and 20% stock, with shareholder approval from Ohio Farmers already received [7][8] 8. **Future Growth Opportunities**: FFBC anticipates significant growth opportunities in consumer lending, wealth management, and specialty banking post-acquisition [10][49] Additional Important Content 1. **Cultural Compatibility**: Both companies share a strong commitment to associates, clients, and communities, which is expected to facilitate the integration process [5][6] 2. **Cost Savings and Renovations**: Initial branch renovations are estimated at $800,000, with plans for branding refreshes post-merger [17][18] 3. **NIM Strategy**: FFBC aims to rebuild the net interest margin (NIM) to around 4% by remixing acquired loans and enhancing commercial product offerings [19][20] 4. **Credit Quality**: The acquisition is expected to slightly improve charge-off rates due to Westfield's strong credit history [41][42] 5. **Future Acquisition Appetite**: FFBC remains open to future acquisitions, depending on size and timing, while maintaining a target tangible common equity (TCE) ratio of 7.5% [30][54] 6. **CECL Adoption**: The impact of the new CECL accounting standard is currently uncertain, but it is not expected to significantly affect the acquisition due to Westfield's clean credit profile [61][62] This summary encapsulates the key points discussed during the conference call regarding the acquisition of Westfield Bancorp by First Financial Bancorp, highlighting the strategic, financial, and operational implications of the deal.

Financial Data and Key Metrics Changes - Mastercard reported strong financial performance with a 25% adjusted EPS CAGR on a currency neutral basis for the three years ending 2024 [46] - The company achieved an 18% currency neutral adjusted net revenue CAGR for the same period [46] - In 2024, Mastercard returned $13.5 billion to shareholders through buybacks and dividends, totaling over $90 billion since its IPO in 2006 [47] Business Line Data and Key Metrics Changes - Services accounted for close to 40% of net revenue in 2022, reflecting a healthy growth pace [37] - The company processed over 159 billion transactions, growing both volumes and transactions by 11% on a local currency basis [45] - Mastercard issued over 3.5 billion cards and had approximately 150 million acceptance points globally [45] Market Data and Key Metrics Changes - Mastercard generates around 70% of its net revenue outside the United States, indicating strong international presence [33] - The company is expanding its domestic switching capabilities across China, enhancing its global acceptance [33] Company Strategy and Development Direction - Mastercard's strategy focuses on three key areas: consumer payments, commercial new payment flows, and value-added services and solutions, which are expected to drive growth [62] - The company emphasizes innovation and trust as core components of its competitive differentiation in the digital economy [38][42] - Mastercard is investing in stablecoin integration and partnerships to enhance its offerings in the digital asset space [56][57] Management's Comments on Operating Environment and Future Outlook - Management highlighted the importance of adapting to geopolitical and macroeconomic changes while maintaining a diversified business model [62] - The company is optimistic about the growth potential in digital payments and the integration of stablecoins into mainstream finance [53][59] Other Important Information - The stockholder proposals for a racial equity audit report and a report on affirmative action risks were not approved [24] - Mastercard has been recognized as one of the most trusted companies in America by Forbes and Newsweek for 2025 [44] Q&A Session Summary Question: How does Mastercard approach executive compensation? - The primary objective of the compensation program is to attract, motivate, and retain executives, ensuring alignment with business strategy and performance metrics [51][52] Question: What are the opportunities and risks associated with stablecoins? - Stablecoins present exciting growth opportunities, and Mastercard is integrating them into its network to provide secure and reliable payment experiences [53][54][56] Question: Is Mastercard ready to adapt to a changing political environment? - Mastercard does not take political stances but operates to serve all geographies, respecting a range of political views grounded in goodwill and tolerance [60][61] Question: What will be the main growth drivers in the coming year? - Key growth drivers include consumer payments, commercial new payment flows, and value-added services, which are expected to fuel long-term growth [62]

智通财经APP获悉，利嘉阁地产研究部主管陈海潮表示，今年一季度，香港私宅落成量达香港差估署预 测(全年20862伙)的34%，预计年内有不少大型项目将陆续取得入伙纸，包括将军澳日出康城12B 期"PARK SEASONS"(685伙)及12A期"SEASONS PLACE"(650伙)、元朗"柏珑III"(680伙)、长沙湾"晓柏 峰"(492伙)等，加上其他中小型项目，初步估计今年落成量约2万至2.1万伙水平，可达到与香港差估署 预测相近数字。 （原标题：利嘉阁：初步估计今年香港私宅落成量约2万至2.1万伙） 根据资料显示，4月份香港共有5个私宅项目正式落成，当中规模最大的是长沙湾"Belgravia Place I期"， 涉及714伙；其次为涉及658伙的油塘"亲海駅II期"。至于，大角咀"利奥坊.首隅"(234伙)、深水湾道6号 (2伙)及何文田布力架街36A号(2伙)亦于期内竣工。 按地区划分，今年前四个月九龙区共有16个项目、合共6729个单位落成，占整体比例约94.8%；港岛区 共有5个项目落成，涉及单位总数368伙，占同期整体私宅落成量约5.2%；新界区则暂未有私宅项目落 成。 根据香港屋宇署的 ...

5月份，杭州二手房市场又降温，市区（含富阳、临安）成交了7716套，成交均价为28833元/㎡，成交量和价格双双下跌，环比分别下降18.1%和2.7%。 (这个成交均价是平均价格有高价位的，也有低价位的，像我们普通人和马云的存款平均数一样)。 杭州钱江晚报旗下潮新闻提供的数据显示，杭州最便宜的单价已经达到了7110元每平米，单格在1万上下的也很正常，甚至在市区的板块的单价也不贵， 普遍在2万上下。当然，有的板块也有5万~10万左右的单价，比如滨江、拱墅、西湖等区域，房价和小区、户型都有很大的关系。 | | 引滨江区成交活跃楼盘均价涨跌情 | | | | --- | --- | --- | --- | | 八区 | 5月成交均价 (元/㎡) | 4月成交均价 (元/㎡) | 环比涨跌情况 | | 银杏汇 | 97720 | | | | 滨江金茂府 | 90750 | 89752 | 1.11% | | 绿城晓风印月 | 90080 | 87500 | 2.95% | | 杭州壹号院 | 88140 | 83800 | 5.18% | | 水晶城 | 55400 | 57290 | -3.30% | | 寰宇天下 ...

这4宗地均按照"价高者得"为原则确定竞得人。地块网上挂牌期限为：7月14日9时至7月25日16时整。 4宗约123亩商住用地 地块一：地籍编号LH8-1-50，宗地位于莲湖区规划路（西斜路）以南、规划路（潘家村北路）以西，净用地面积10.752亩，住宅、商服共用宗。 规划地上总建筑面积17920㎡，地块容积率2.5，建筑密度不大于35%，绿地率不小于35%。起始价9301万元，竞买保证金1900万元。 6月24日，莲湖区4宗约123亩商住用地出让，起始价合计为12.49亿元。 莲湖区出让的这4宗地均位于二环内，位置优势明显，容积率均为2.5。 其中LH11-4-165宗地位于西电城市更新板块，地块近西二环，且距离周边地铁1号线、8号线较近，地块周边交通非常便利。 另外，地块周边分布着万达广场、太奥广场、以及大庆路上的风华茂等商业，购物非常方便。地块所在板块分布有莲湖区劳动路小学、莲湖行知小学、西 电中学、西电集团医院、劳动公园等配套设施，居住非常便利。 | 序号 | 地块编号 | 土地位置 | 净用地 | 净用地 | 地上总 | 土地 周途 | 用非 | | 竞头 | | | 规划指标要求 | | 挂牌期限 ...

154轮竞价、75.7%溢价率——近日，厦门国贸地产集团有限公司（下称"国贸地产"）杀出重围，以23.26亿元摘得成都起拍价最高、 成交单价历史第二高的地块。 国贸地产"豪赌"高价地 6月19日，成都两宗地迎来土拍，其中，锦江区东大街板块位于黄金二环位置，总土地出让面积6.2万平方米，总建筑规划面积15.66 万平方米，总起始价26.16亿元，起始楼面价为20200元/平方米，是成都起始楼面价最高的地块。 由于地理位置优越且周边配套丰富，这块地吸引了包括华润置地、保利发展、金茂、越秀、华发、国贸、招商蛇口、中海等实力房 企参与，最终由国贸地产以35500元/平方米的楼面价竞得，成交总价约23.26亿元，溢价率为75.74%，成功跻身为成都涉宅用地成交 楼面价TOP2。 高溢价将这块地收入囊中，国贸地产的机遇和挑战并存。对此，同策研究院联席院长宋红卫认为："3.5万元/平方米的楼面价，2.55 的容积率限制了低密产品的打造，会有一定压力，但也有很多机会。从市场来看，核心城市目前成交的主力都是中高端改善项目， 成都也是如此；周边优质二手房价格坚挺，因此，这个项目未来或可达到（单价）6万+的水平。" 而此次敢在成都 ...

新京报贝壳财经讯 （记者段文平）杭州土地市场持续呈现"核心区火热、外围遇冷"的分化格局。据中 指研究院统计，6月24日，杭州迎来3宗住宅用地出让，2宗位于临平区、1宗位于钱塘区，总土地出让面 积88181平方米，总规划建筑面积104620平方米，总起始价11.67亿元。最终，3宗地块均底价成交，共 收金11.67亿元。 在中指研究院华东大区常务副总高院生看来，3宗地块均以起始价完成交易，未出现溢价现象，直接反 映出当前杭州土地市场的降温态势。 临平、钱塘3宗地底价成交 而核心区则是另一番风景，5月29日，绿城竞得拱墅区康桥单元住宅用地，成交金额13.74亿元，溢价率 40.33%；5月20日，保利置业竞得西湖区三墩单元XH010401-24地块，成交总价17.09亿元，溢价率 51.38%；拱墅区东新单元XC0603-R21-01地块，则由杭州西湖房地产以总价16.25亿元竞得，成交楼面 价41305元/平方米，溢价率41.93%。 具体来看，临平区昌达路与顺意路交会处西南地块、五洲路与顺意路交会处西北地块，均由浙江杰立房 地产开发有限公司和杭州承弘置业有限公司组成的联合体摘得。前者规划建筑面积37596平方 ...

ATHENS, Greece, June 24, 2025 (GLOBE NEWSWIRE) -- Performance Shipping Inc. (NASDAQ: PSHG), (“we” or the “Company”), a global shipping company specializing in the ownership of tanker vessels, today announced that it has accepted a commitment letter whereby it intends to enter into an agreement for a refinancing of the existing loan outstanding of US$29,750,000 with Alpha Bank A.E. (the “Facility”) through two separate wholly-owned subsidiaries of the Company. This Facility is subject to the completion of cu ...

WISe.ART Launches Mayte Spínola’s “Galactic Christ” into Space Aboard SpaceX Mission Pioneering Space-Based Art NFTs and Digital Expression Geneva, Switzerland, June 24, 2025 –WISeKey International Holding Ltd (“WISeKey”) (SIX: WIHN, NASDAQ: WKEY), a leading global cybersecurity, blockchain, and IoT company, today announces that WISe.ART, its secure NFT marketplace subsidiary has successfully launched Spanish artist Mayte Spínola’s digital artwork El Cristo Cósmico (“The Galactic Christ”) into low Earth o ...