​Salesforce, Inc. (NYSE:CRM) is one of the Best Quality Stocks to Buy Before 2026. On December 17, Salesforce, Inc. (NYSE:CRM) announced that Novartis (NYSE:NVS) has selected the company’s Agentforce Life Sciences for Customer Engagement to connect patients and Healthcare professional experiences. ​Novartis has already invested in the company through Agentforce Health, 360 for Health & Life Sciences, MuleSoft for Life Sciences, and Agentforce Marketing. Now it plans to unify the engagement across marketin ...

Core Insights - Salesforce, Inc. (NYSE:CRM) is recognized as one of the best quality stocks to buy before 2026, particularly following its announcement of a partnership with Novartis to enhance customer engagement in the healthcare sector [1] Group 1: Partnership and Investment - Novartis has previously invested in Salesforce through various platforms including Agentforce Health and MuleSoft for Life Sciences, and now aims to unify engagement across multiple teams over the next five years [2] - The partnership will involve the global deployment of Agentforce 360 for Life Sciences, indicating a significant commitment to integrating Salesforce's technology within Novartis [2] Group 2: Market Sentiment and Analyst Ratings - Wall Street analysts are optimistic about Salesforce, with BTIG's Allan Verkhovski initiating coverage with a Buy rating and a price target of $335, while Mizuho Securities' Gregg Moskowitz reiterated a Buy rating with a $340 price target [3] - Analyst Verkhovski appreciates Salesforce's re-architecture of its core platform and anticipates that the company's net new annual order value will accelerate, leading to a return to double-digit subscription revenue growth by fiscal Q4 2027 [4]

Core Viewpoint - The article discusses the challenges of treating castration-resistant prostate cancer (CRPC), particularly the neuroendocrine subtype (CRPC-NE), and highlights a new dual-targeting therapeutic strategy involving NSD2 and androgen receptor (AR) to address drug resistance and tumor plasticity [1][2][6]. Group 1: CRPC and Its Subtypes - CRPC often retains adenocarcinoma histological features and AR expression but can progress to neuroendocrine subtypes that are highly resistant to AR inhibitors [1][4]. - CRPC-NE occurs in approximately 5%-25% of metastatic CRPC cases and is characterized by aggressive behavior, treatment resistance, and poor clinical prognosis [1][4]. Group 2: NSD2 Targeting Research - A study published in Nature indicates that targeting NSD2 can reverse plasticity and drug resistance in prostate cancer, providing a potential new treatment avenue for lethal CRPC subtypes [2][6]. - NSD2, a histone lysine methyltransferase, plays a crucial role in regulating chromatin structure and gene expression, and its inhibition can successfully reverse treatment resistance in CRPC [4][5]. Group 3: Mechanism of Action - In engineered mouse models and human CRPC-NE organoids, knocking out NSD2 can revert the CRPC-NE phenotype back to adenocarcinoma, restoring sensitivity to AR inhibitors like enzalutamide [5]. - The use of first-in-class NSD2 small molecule inhibitors has shown promise in reversing tumor plasticity and enhancing the efficacy of AR inhibitors in various CRPC subtypes [5][6]. Group 4: Broader Implications - The findings suggest that targeting the NSD2-H3K36me2 signaling axis could serve as an effective treatment strategy for difficult-to-treat cancers, including lung and pancreatic cancers, as indicated by related research [7][9].

Group 1 - Capital is increasingly directed towards high-growth AI companies, leading to a neglect of other investment opportunities due to the prevailing AI trend in the markets [1] - There is a concern regarding a potential patent cliff, which refers to the loss of revenue from drugs that are going off-patent [1] Group 2 - The article emphasizes the importance of combining top-down macro analysis with bottom-up stock selection to identify mispriced opportunities in the market [1] - The focus areas include earnings, technological disruption, policy shifts, and capital flows, which are critical for investment decision-making [1]

Group 1 - Capital is increasingly directed towards high-growth AI companies, leading to a neglect of other investment opportunities due to the prevailing AI trend in the markets [1] - There is a concern regarding a potential patent cliff, which refers to the loss of revenue from drugs that are going off-patent, impacting pharmaceutical companies [1] Group 2 - The article emphasizes the importance of combining top-down macro analysis with bottom-up stock selection to identify mispriced opportunities in the market [1] - It highlights the focus on earnings, technological disruption, policy shifts, and capital flows as key factors in investment decision-making [1]

Market Overview - Asian shares exhibited mixed performance amid thin holiday trading, with most markets closed for Christmas. The Nikkei 225 in Tokyo increased by 0.1% to 50,407.79, marking a nearly 30% gain for the year [1] - The Shanghai Composite index in mainland China rose by 0.5% to 3,959.62, while Hong Kong's exchange was closed [1] Central Bank Actions - The People's Bank of China (PBOC) reassured investors by committing to ensure adequate money supply to support financing, economic growth, and inflation targets. The PBOC maintained its key short-term lending rates earlier in the week [2] US Market Performance - The S&P 500 index increased by 0.3% to 6,932.05, while the Dow Jones Industrial Average rose by 0.6% to 48,731.16, and the Nasdaq composite added 0.2% to 23,613.31 [3] - The S&P 500 has gained over 17% this year, driven by investor optimism regarding the Trump administration's deregulatory policies and the potential of artificial intelligence to enhance profits across various sectors [5] Economic Indicators - The US economy experienced a robust growth rate of 4.3% annually in Q3, the fastest in two years, primarily fueled by consumer spending despite high inflation [7] - Jobless claims in the US decreased by 10,000 to 214,000 for the week ending December 20, remaining below the forecast of 232,000 new applications, indicating a still healthy labor market [8] Company News - Dynavax Technologies' shares surged by 38.2% following Sanofi's announcement of acquiring the company for $2.2 billion, which will enhance Sanofi's vaccine portfolio [9] - Novo Nordisk's shares rose by 1.8% after receiving US regulatory approval for a pill version of its weight loss drug Wegovy, although the company’s shares are down nearly 40% this year due to increased competition from Eli Lilly, whose shares have increased by 40% this year [10]

Core Insights - Rezolute, Inc. experienced a significant decline in its stock price following disappointing results from its Phase 3 sunRIZE clinical trial for its lead drug candidate, ersodetug, which failed to meet primary and key secondary endpoints [4][5] Group 1: Company Overview - Rezolute, Inc. is publicly traded on NASDAQ under the ticker RZLT [2] - The company is focused on developing treatments for congenital hyperinsulinism [4] Group 2: Clinical Trial Results - The Phase 3 sunRIZE clinical trial for ersodetug did not achieve statistically significant reductions in hypoglycemia events compared to placebo [4] - The highest dose in the trial showed reductions that were not statistically significant [4] Group 3: Stock Performance - On December 11, 2025, Rezolute's stock price plummeted from approximately $10.94 to an intraday low of around $0.90, marking an approximate 85-90% drop [5] - Trading was halted under Nasdaq's volatility controls due to the drastic decline [5]

Core Viewpoint - Rosen Law Firm is reminding investors who purchased Telix Pharmaceuticals Ltd. securities between February 21, 2025, and August 28, 2025, about the January 9, 2026, deadline to become a lead plaintiff in a securities class action lawsuit [1]. Group 1: Class Action Details - Investors who purchased Telix securities during the specified Class Period may be entitled to compensation without any out-of-pocket fees through a contingency fee arrangement [2]. - A class action lawsuit has already been filed, and interested parties can join by contacting Rosen Law Firm [3]. - The lawsuit alleges that defendants made materially false and misleading statements regarding Telix's progress in prostate cancer therapeutic candidates and the quality of its supply chain, leading to investor damages when the truth was revealed [5]. Group 2: Rosen Law Firm's Credentials - Rosen Law Firm emphasizes the importance of selecting qualified legal counsel with a successful track record in securities class actions, highlighting its own achievements, including the largest securities class action settlement against a Chinese company [4]. - The firm has been ranked No. 1 for securities class action settlements in 2017 and has consistently ranked in the top 4 since 2013, recovering hundreds of millions of dollars for investors [4].

Core Insights - The article discusses the rising popularity of glucagon-like peptide-1 (GLP-1) agonists, particularly Ozempic, as effective weight management solutions for individuals struggling with obesity and diabetes [1][3][4]. Group 1: Ozempic Overview - Ozempic is an injectable medication primarily used for managing blood sugar levels in adults with type 2 diabetes, but it has gained attention for its potential weight loss effects [7][22]. - The active ingredient in Ozempic, semaglutide, is FDA-approved in higher doses for treating obesity under the name Wegovy [7][26]. - Ozempic is administered once a week via a pre-filled pen injector, making it a long-acting option compared to other diabetes medications [23]. Group 2: Weight Loss Efficacy - Clinical trials indicate that individuals taking Ozempic can experience weight loss, with an average loss of approximately 8 lbs over 30 weeks at a 0.5 mg dose, and up to 15 lbs at a 2 mg dose over 40 weeks [39][40]. - Wegovy, with a higher dosage of 2.4 mg, has shown that individuals can lose 10% of their initial body weight in the first 20 weeks [41]. - The weight loss effects of semaglutide are attributed to its ability to modulate hunger centers in the brain and slow gastric emptying, leading to reduced appetite and prolonged feelings of fullness [28][27]. Group 3: Market Demand and Shortages - The popularity of Ozempic has led to shortages as demand increases, particularly for off-label use in weight loss among individuals without diabetes [3][34]. - The high demand for Wegovy has also resulted in significant availability issues, prompting many to seek Ozempic as an alternative [34]. Group 4: Alternative Solutions - PhenQ is presented as an alternative weight loss supplement that claims to suppress cravings and assist in fat loss, although it is not a direct substitute for Ozempic [12][25]. - The article highlights the importance of lifestyle modifications, including diet and exercise, to maximize the benefits of medications like Ozempic and Wegovy [42].

Core Viewpoint - AbbVie has shown strong financial performance and growth potential, making it an attractive investment option heading into 2026 [2][3][11] Financial Performance - AbbVie's revenue increased by 8% year over year to $44.5 billion in the first nine months of the year [3] - Adjusted earnings per share declined to $7.29 from $7.96, primarily due to acquisition-related charges, but this is not a major concern [3] - The company projects high single-digit revenue growth through 2029, indicating sustained financial momentum [3] Growth Drivers - AbbVie has revised its 2027 sales projections for Skyrizi and Rinvoq, increasing it by $4 billion, which are key growth drivers [5] - Other contributors to growth include Vraylar for schizophrenia and Qulipta for migraines [6] - Humira, despite losing patent exclusivity, generated $3.3 billion in sales in the first nine months of 2025, although its revenue declined by 55% year over year [6] Challenges - The U.S. government has targeted Vraylar for drug price negotiations, effective in 2027, but management does not expect significant long-term impacts [7] - AbbVie anticipates no loss of patent exclusivity for major growth drivers through the end of the decade [7] Valuation and Dividend - AbbVie is trading at 16.1 times forward earnings, below the healthcare sector average of 18.2, suggesting reasonable valuation [9] - The company's PEG ratio is currently 0.4, indicating that shares are undervalued [10] - AbbVie has a strong dividend program, with a forward yield of 3% and a cash payout ratio of 61.8%, making it a Dividend King with 54 consecutive annual dividend increases [10][11]