Viking Therapeutics - Viking Therapeutics' stock has declined by 37% this year due to disappointing phase 2 results for its oral GLP-1 weight loss candidate, VK2735, with 20% of participants dropping out due to adverse side effects, primarily gastrointestinal issues [4][5] - Despite the setback, Wall Street analysts remain bullish, with an average price target of $88.78, suggesting a potential upside of 245% from current levels [2] - The phase 2 study showed an average weight loss of 12.2% at the highest dose after 13 weeks, with no weight-loss plateau observed, indicating strong efficacy compared to competitors [6][7] - Viking has a promising pipeline, including a subcutaneous version of VK2735 in phase 3 studies and another candidate, VK2809, for metabolic dysfunction-associated steatohepatitis, expected to advance to phase 3 soon [8][9] Regeneron Pharmaceuticals - Regeneron Pharmaceuticals has faced competition from biosimilars for its Eylea medication, but the newly approved high-dose formulation is helping mitigate losses [10] - The company's revenue increased by 4% year over year to $3.68 billion, driven by strong performance from eczema treatment Dupixent, which saw a 22% increase in worldwide sales to $4.34 billion [11] - Regeneron is expected to earn label expansions for Eylea HD in the U.S. and has recently received approval for Lynozyfic, a new cancer medicine [12] - The company has a robust pipeline, including trevogrumab for muscle loss in patients using GLP-1 weight management medicines and a gene therapy for a type of genetic deafness [13] - Despite current stock declines, Regeneron is positioned to deliver superior long-term returns to patient investors [14]

Core Insights - The analysis on Viking (NASDAQ: VKTX) indicates a promising outlook for the company, suggesting it is emerging as a significant player in its industry [1]. Company Analysis - Viking is positioned to capitalize on market opportunities, with signs pointing towards its potential growth and value creation [1]. Market Context - The investment landscape is characterized by various market cycles, and the analysis reflects a deep understanding of these dynamics, emphasizing the importance of identifying undervalued equities with long-term potential [1].

Core Viewpoint - Viking Therapeutics' shares dropped 36% following mixed results from a mid-stage study of its obesity drug VK2735, raising concerns about the drug's safety and tolerability [1][11]. Company Analysis - VK2735 showed a 12.2% weight loss in patients on the highest dose after 13 weeks, compared to 1.3% in the placebo group, but high dropout rates were noted [1]. - Management suggested that side effects could be mitigated by gradually increasing doses, yet investor sentiment remains negative [2]. - The company currently has no marketed products and faces significant cash burn due to ongoing clinical studies, prompting a focus on the obesity pipeline [8]. Market Competition - The obesity market is projected to reach $100 billion in the U.S. by 2030, with Eli Lilly and Novo Nordisk leading the injectable segment [4]. - Both Eli Lilly and Novo Nordisk are also developing oral weight-loss pills, with recent disappointing results from Lilly's oral GLP-1 pill study [5]. - Novo Nordisk is seeking FDA approval for an oral version of Wegovy, which could enhance its competitive position in the obesity market [6]. Stock Performance and Valuation - Viking Therapeutics' stock has underperformed, dropping 38% this year compared to a 4% growth in the industry [12]. - The stock trades at a premium with a price/book ratio of 3.63, higher than the industry average of 2.98 [14]. - Estimates for losses per share for 2025 and 2026 have widened significantly in the past month [14].

Group 1 - The article discusses the potential for undervalued stocks that are mispriced by the market as of the end of August [1] - It suggests that investors may consider joining a platform for insights on these investment opportunities [1] Group 2 - There is a mention of a potential long position in VKTX that may be initiated within the next 72 hours [2] - The article emphasizes that the opinions expressed are those of the author and not influenced by any compensation from companies mentioned [2] Group 3 - The information provided is intended for informational purposes only and does not constitute a solicitation to buy or sell securities [3] - It highlights the importance of conducting personal research or consulting a financial advisor before making investment decisions [3]

Core Insights - Viking Therapeutics' shares fell 42% following the phase II VENTURE-Oral Dosing study results for VK2735, despite achieving primary and secondary endpoints [1][4] - The study showed significant weight loss in participants, with the highest dose resulting in a 12.2% reduction in body weight [3][6] - High patient dropout rates due to adverse events raised concerns about the drug's tolerability, impacting investor sentiment [4][6] Company Summary - The VENTURE-Oral Dosing study involved approximately 280 adults with obesity or overweight conditions, randomized into six dosing arms [2] - Participants on the highest dose (120 mg) lost an average of 26.6 lbs over 13 weeks, while the placebo group lost only 1.3% [3] - The dropout rate for VK2735 was 28%, compared to 18% for the placebo, leading to skepticism about the drug's market viability [4][6] Industry Context - The obesity market is projected to reach $100 billion in the U.S. by 2030, attracting significant interest from pharmaceutical companies [8] - Eli Lilly and Novo Nordisk are key players in the obesity treatment space, with ongoing developments in oral weight-loss pills [9] - Novo Nordisk is likely to be the first to market an oral obesity pill, with a regulatory filing under FDA review for an oral version of Wegovy [9]

CANADA - 2025/06/14: In this photo illustration, the Viking Therapeutics logo is seen displayed on a smartphone screen. (Photo Illustration by Thomas Fuller/SOPA Images/LightRocket via Getty Images)SOPA Images/LightRocket via Getty ImagesViking Therapeutics (NASDAQ: VKTX) fell 42% on August 19, 2025, after Phase 2 results for its oral obesity pill VK2735 disappointed investors. The oral formulation led to up to 12.2% weight loss over three months, a weaker outcome versus late-stage treatments from Eli Lilly ...

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Core Viewpoint - Viking Therapeutics Inc. experienced its largest single-day stock drop, falling 42%, primarily due to disappointing mid-stage trial results of its experimental oral weight-loss drug, which led to significant short-seller profits [1][2]. Group 1: Stock Performance and Market Reaction - The stock price of Viking Therapeutics fell by 42%, resulting in a single-day profit of $521 million for short-sellers, reversing their earlier losses of approximately $140 million [1]. - The annual profit for short-sellers reached over $380 million following the stock's decline [1]. Group 2: Clinical Trial Results - The decline in stock price was attributed to adverse side effects from the weight-loss drug, with about 28% of patients dropping out of the trial within three months [1]. - High rates of nausea and vomiting were reported across all treatment groups, overshadowing efficacy data [1]. Group 3: Analyst Outlook - Despite the recent stock drop, nearly 90% of analysts covering Viking Therapeutics maintain a "buy" rating, with an average target price of around $90, indicating over three times potential upside [2]. - Oppenheimer & Co. analyst Jay Olson reiterated a "outperform" rating with a target price of $100, suggesting that the market's concerns regarding the drug's tolerability may be overestimated [2].

Group 1 - Viking Therapeutics Inc. experienced a significant stock price drop of 42%, resulting in a one-day gain of $521 million for short sellers, reversing earlier losses for the year [1] - The decline was attributed to adverse mid-stage trial results of an experimental oral weight loss drug, with approximately 28% of patients dropping out due to side effects, undermining market expectations of competition with popular injectable weight loss products from Eli Lilly and Novo Nordisk [1] - Piper Sandler analyst Biren Amin noted that "tolerability issues overshadowed efficacy data," highlighting high rates of nausea and vomiting across all treatment groups in the study [1] Group 2 - Despite the stock price drop, nearly 90% of analysts maintain a "buy" rating for Viking Therapeutics, with an average target price of around $90, indicating over three times potential upside from current trading levels [2] - Oppenheimer & Co. analyst Jay Olson described the stock's weakness as a buying opportunity, suggesting that market concerns regarding tolerability issues are exaggerated, while reiterating a "outperform" rating and a target price of $100 [2]

Core Viewpoint - Viking Therapeutics Inc. experienced a significant stock price drop of 42%, leading to substantial gains for short sellers and reversing earlier losses for the year [1][4] Group 1: Stock Performance - The stock price decline resulted in a paper profit of $521 million for short sellers on that day, bringing their year-to-date profits to over $380 million, compared to a loss of approximately $140 million as of the previous close [1] - This drop marked the largest single-day decline in the company's history [1] Group 2: Clinical Trial Results - The stock price plunge was attributed to disappointing mid-stage trial results for an experimental oral weight-loss drug, which saw about 28% of participants drop out due to side effects [4] - The adverse effects overshadowed efficacy data, with high rates of nausea and vomiting reported across all treatment groups [4] - This incident follows another recent oral weight-loss drug trial from Eli Lilly that also failed to meet Wall Street expectations, resulting in a 14% stock drop, the largest since 2000 [4] Group 3: Analyst Ratings - Despite the negative news, nearly 90% of analysts maintain a "buy" rating for Viking Therapeutics, with an average target price of around $90, indicating over three times potential upside from current trading levels [4] - Oppenheimer & Co. analyst Jay Olson views the stock's decline as a buying opportunity, suggesting that market concerns regarding tolerability issues are overstated, while reiterating a "outperform" rating and a $100 target price [4]