Core Insights - Wuxi AppTec reported a strong performance in the first half of 2025, with revenue reaching 20.799 billion yuan, a year-on-year increase of 20.64% [1] - The net profit attributable to shareholders was 8.56 billion yuan, reflecting a significant year-on-year growth of 101.92% [1] - The company plans to increase its full-year revenue forecast to between 42.5 billion and 43.5 billion yuan, up from the previous estimate of 41.5 billion to 43 billion yuan [4] Financial Performance - Revenue from continuing operations grew by 24.24% year-on-year [1] - Adjusted net profit (non-IFRS) for the first half of 2025 increased by 44.4% [5] - The company achieved a record high of 56.7 billion yuan in backlog orders for continuing operations [5] Shareholder Returns - Wuxi AppTec announced a special dividend of approximately 1 billion yuan, which has already been completed [5] - The board approved a mid-year profit distribution plan, proposing a total cash dividend of around 1 billion yuan [5] - The company has executed multiple share repurchase plans totaling 4 billion yuan since 2024, with the latest repurchase amounting to 1 billion yuan [6][8] Future Outlook - The company expects its continuing operations revenue growth to return to double digits, with an adjusted growth rate of 13-17% [4] - Capital expenditures for 2025 are projected to reach 7-8 billion yuan, with free cash flow expectations adjusted to 5-6 billion yuan [5]

Core Viewpoint - The FDA has updated its policy to gradually eliminate mandatory animal testing for monoclonal antibody therapies and other drug developments, which has raised significant concerns in the industry, particularly for companies like Zhaoyan New Drug that rely heavily on animal testing [1][2]. Group 1: FDA Policy Changes - The FDA's new policy encourages the use of alternative methods such as computational models, organ-on-a-chip technology, and cross-species data integration to replace animal testing [1][4]. - The FDA's push for alternatives is seen as a potential milestone in drug development, which could impact not only domestic CRO companies but also global pharmaceutical research [4][5]. Group 2: Impact on Zhaoyan New Drug - Zhaoyan New Drug, which derives 95% of its revenue from non-clinical research, faces direct challenges as approximately 70% of its business involves animal testing [10][11]. - The company has a significant portion of its business (78%) from the domestic market, with only 22% from international markets, primarily the U.S. [10][11]. Group 3: Feasibility of Alternatives - The feasibility of AI and organ-on-a-chip technologies as alternatives to animal testing is being explored, with some advancements already noted in clinical trials [5][7]. - The FDA has previously approved a new drug based solely on organ-on-a-chip data, indicating that there is a pathway for these technologies to be integrated into drug development [7]. Group 4: Financial Implications - If animal testing is reduced, the cost of monkeys used in experiments may decline significantly, impacting Zhaoyan New Drug's investments in animal resources [14]. - The company's financial growth may increasingly depend on its clinical business, which is facing intense competition and declining profit margins [15].

股票简称：万邦医药 股票代码：301520 安徽万邦医药科技股份有限公司 Anhui Wanbang Pharmaceutical Technology Co.,Ltd. （安徽省合肥市高新区明珠大道与火龙地路交口西南角安徽万邦医药 1 号楼） 二零二三年九月 特别提示 安徽万邦医药科技股份有限公司（以下简称"万邦医药"、"本公司"或"发 行人"、"公司"）股票将于 2023 年 9 月 25 日在深圳证券交易所创业板上市， 该市场具有较高的投资风险。创业板公司具有业绩不稳定、经营风险高、退市风 险大等特点，投资者面临较大的市场风险。投资者应充分了解创业板市场的投资 风险及本公司所披露的风险因素，审慎做出投资决定。 本公司提醒投资者应充分了解股票市场风险以及本公司披露的风险因素，在 新股上市初期切忌盲目跟风"炒新"，应当审慎决策、理性投资。 如无特别说明，本上市公告书中的简称或名词的释义与本公司首次公开发行 股票并在创业板上市招股说明书中的相同。 首次公开发行股票并在创业板上市 之 上市公告书 保荐人（主承销商） （中国（上海）自由贸易试验区浦明路 8 号） 1 | | | | 特别提示 | 1 | | -- ...