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Is it Prudent to Retain Charles River Stock in Your Portfolio Now?
ZACKS· 2025-07-16 13:21
Core Insights - Charles River Laboratories International, Inc. (CRL) is expanding its product and service offerings in drug discovery and early-stage development through strategic partnerships and acquisitions [1][6] - The Discovery and Safety Assessment (DSA) segment shows signs of stabilization with improved bookings, although macroeconomic challenges and currency fluctuations present risks [1][8] Financial Performance - Year-to-date, CRL's shares have declined by 16.4%, while the industry has seen a 4.2% decline, and the S&P 500 has increased by 6% [2] - The company has a market capitalization of $7.76 billion and an earnings yield of 6%, outperforming the industry's 4.1% [2] - CRL has consistently beaten earnings estimates over the past four quarters, with an average surprise of 10.9% [2] Growth Drivers - The DSA segment is a potential growth driver, being the largest provider of outsourced drug discovery and non-clinical development services globally [4] - In Q1 2025, DSA's net book-to-bill ratio exceeded 1X for the first time in over two years, indicating improved quarterly bookings and expected incremental revenues in 2025 [5][9] - Strategic partnerships, such as those with Akron Bio, Deciphex, H. Lundbeck A/S, and Autobahn Labs, are enhancing CRL's capabilities in drug development and research [6][7] Challenges - The company faces a cautious spending environment among biopharmaceutical and biotechnology clients, particularly due to reduced research grants from the NIH [8] - Macroeconomic factors, including tariffs on imports from key supplier countries, are impacting CRL's operations [8] - Foreign exchange fluctuations pose significant challenges, as a considerable portion of CRL's revenues is generated outside the U.S., with the strengthening dollar exacerbating these issues [10] Earnings Estimates - The Zacks Consensus Estimate for CRL's 2025 earnings remains at $9.62 per share, while revenues are projected at $3.89 billion, reflecting a 3.9% decrease from the previous year [11]
Cell Research：邓宏魁/屈默龙/顾晋团队构建新型患者来源类器官模型，捕获结直肠癌胎儿样可塑性状态
生物世界· 2025-07-06 07:34
撰文丨王聪 编辑丨王多鱼 排版丨水成文 表型可塑性 （ Phenotypic plasticity ） 是驱动癌症进展、转移和治疗耐药性的显著特征。胎儿样 （ Fetal-like ） 转录程序在促进细胞的可塑性状态方面的作用 日益受到关注，但由于现有培养模型的局限性，其作用仍难以研究。 2025 年 7 月 4 日，北京大学 邓宏魁 教授、 屈默龙 副研究员、北京大学首钢医院/北京大学肿瘤医院 顾晋 教授团队 （ 熊亮 、 徐莹 、 高兆亚 为共同第一作 者 ） 在 Cell Research 期刊发表了题为 ： A patient-derived organoid model captures fetal-like plasticity in colorectal cancer 的研究论文。 该研究开发了一种 化学成分明确的患者来源的类器官系统 （ CiPDO ） ，并用该类器官系统捕捉到了 结直肠癌 的 胎儿样可塑性 状态 。 在这项最新研究中，研究团队建立了一种 化学成分明确的患者来源的类器官系统 （ CiPDO ） ，培养条件是 EGF + CHIR99021 （Wnt激动剂） + LDN- 214 ...
Cuprina Provides Update on Research Studies with Three Leading Education Institutes
Globenewswire· 2025-06-30 12:00
SINGAPORE, June 30, 2025 (GLOBE NEWSWIRE) -- Cuprina Holdings (Cayman) Limited (Nasdaq: CUPR) (“Cuprina” or “the Company”), a biomedical and biotechnology company dedicated to the development and commercialization of products for the management of chronic wounds and infertility, as well as cosmeceuticals for the health and beauty sector, today provided an update on progress achieved in relation to three studies carried out with institutes of higher learning. The studies, each one year in length, were aimed ...
对谈斯坦福 Biomni 作者黄柯鑫：AI Scientist 领域将出现 Cursor 级别的机会｜Best Minds
海外独角兽· 2025-06-20 11:18
嘉宾：黄柯鑫 访谈：Penny、Cage 随着语言模型在强化学习和 agentic 领域的进步，agent 正在从通用领域快速渗透到垂直领域，科学和生物医药这类高价值领域尤其受到关注。如 果说 AlphaFold 在 foundation model 层面是生命科学的重要里程碑，AI scientist 就是在 agent 层面，能够给科研带来和 alphafold 同样重要的影响。 今年 5 月，前谷歌 CEO Eric Schmidt 投资的 AI lab FutureHouse 推出了四款 AI scientist agent，一个月后，他们又宣布自己的 AI 系统 Robin 成功发 现了新药。两天前，OpenAI 也发布博客强调 AI 在生物学领域的能力正在不断增强。AI scientist 已经在改写科研和药物开发范式。 随着 multi-agent 技术的发展，AI 可能不再只是"工具箱"，而是能自主完成跨学科复杂研究，从而推动科学发现走向全新模式。 最近，斯坦福大学也发布了一个生物医学通用 agent Biomni，Biomni 搭建了一个适合 agent 的环境，通过整合不同的工具、数据库、 ...
