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Cell Research：邓宏魁/屈默龙/顾晋团队构建新型患者来源类器官模型，捕获结直肠癌胎儿样可塑性状态
生物世界· 2025-07-06 07:34
撰文丨王聪 编辑丨王多鱼 排版丨水成文 表型可塑性 （ Phenotypic plasticity ） 是驱动癌症进展、转移和治疗耐药性的显著特征。胎儿样 （ Fetal-like ） 转录程序在促进细胞的可塑性状态方面的作用 日益受到关注，但由于现有培养模型的局限性，其作用仍难以研究。 2025 年 7 月 4 日，北京大学 邓宏魁 教授、 屈默龙 副研究员、北京大学首钢医院/北京大学肿瘤医院 顾晋 教授团队 （ 熊亮 、 徐莹 、 高兆亚 为共同第一作 者 ） 在 Cell Research 期刊发表了题为 ： A patient-derived organoid model captures fetal-like plasticity in colorectal cancer 的研究论文。 该研究开发了一种 化学成分明确的患者来源的类器官系统 （ CiPDO ） ，并用该类器官系统捕捉到了 结直肠癌 的 胎儿样可塑性 状态 。 在这项最新研究中，研究团队建立了一种 化学成分明确的患者来源的类器官系统 （ CiPDO ） ，培养条件是 EGF + CHIR99021 （Wnt激动剂） + LDN- 214 ...
细菌巧造人工耳！马竞/张天宇团队突破耳廓畸形修复难题，利用细菌编织人工耳廓支架
生物世界· 2025-05-27 03:57
Core Viewpoint - The article discusses a breakthrough in reconstructive surgery for ear deformities, utilizing bacteria as a "biological 3D printer" to create customizable artificial ear scaffolds, potentially transforming clinical practices in auricular reconstruction [2][4]. Group 1: Challenges in Traditional Methods - Traditional ear reconstruction methods involve harvesting rib cartilage, which presents three main challenges: insufficient rib cartilage in children requiring multiple surgeries, the complexity of sculpting and stitching that relies heavily on the surgeon's skill, and the risk of postoperative complications such as infections and scaffold exposure [4][5]. - Existing artificial materials used as cartilage substitutes also face issues, including manual shaping and stitching, along with the risk of rejection [4]. Group 2: Innovative Approach - The research team focused on the bacterium Komagataeibacter xylinus, which can synthesize bacterial cellulose known for its high purity, nanoscale network structure, excellent biocompatibility, and functionalization properties [4][5]. - The bacteria exhibit an "oxygen navigation" feature, allowing them to gather in oxygen-rich areas and secrete nanofibers, which are utilized to create the ear scaffold [5]. Group 3: Key Innovations in Scaffold Production - The team designed a high-oxygen-permeable silicone mold to achieve three critical controls: precise molds created from 3D-printed ear models, dynamic oxygen supply to guide bacteria evenly throughout the scaffold, and nanometer-level precision in the cellulose fibers produced [5][7]. - The cellulose fibers have a diameter of 20-100 nanometers and form a cartilage-like network structure with mechanical strength comparable to real ear cartilage, with an elastic modulus ranging from 3.89 to 9.56 MPa [5][8]. Group 4: Performance and Clinical Implications - After 21 days of bacterial "biomanufacturing" and purification, the artificial ear scaffolds demonstrated remarkable characteristics: precise replication of ear structures, high tensile strength with no deformation after 50 days of immersion, long-term stability in the body, and extremely low endotoxin levels [8][9]. - The scaffolds show over 95% survival rates for cartilage and skin cells, allowing for rapid integration with surrounding tissues, indicating significant clinical application potential for personalized ear reconstruction [9]. Group 5: Broader Impact - This research marks the first application of microbial manufacturing technology in organ reconstruction, offering hope for patients with ear deformities and paving the way for future developments in complex tissue engineering, potentially extending to heart valves and vascular networks [9].
KROGER PARTNERING WITH THE LEUKEMIA & LYMPHOMA SOCIETY (LLS) TO HELP KIDS WITH BLOOD CANCER
Prnewswire· 2025-05-14 13:00
Core Insights - The Leukemia & Lymphoma Society (LLS) has partnered with Kroger's Dallas Division to raise funds for The Dare to Dream Project, aimed at improving treatments for pediatric blood cancer patients and providing support for their families [1][2][4] Group 1: The Dare to Dream Project - The Dare to Dream Project is a $175 million campaign focused on funding pediatric blood cancer research, advocating for healthcare policy changes, and expanding support services for affected children and families [8] - Only 5% of cancer drugs have been approved for first-time use in children, and 80% of childhood cancer survivors face chronic health issues due to their treatments [3] Group 2: Fundraising Efforts - From May 14 to June 3, 2025, Kroger encourages customers to donate at checkout in 110 stores across North and East Texas and Louisiana to support LLS's Dare to Dream Project [2] - Funds raised will exclusively benefit the life-saving work of The Dare to Dream Project, helping to ensure better treatment outcomes for children with blood cancer [1][2] Group 3: LLS's Commitment - LLS is pioneering pediatric blood cancer research, including the establishment of the first-ever pediatric AML Data Commons and the launch of the LLS PedAL Master Clinical Trial [4] - The organization has been dedicated to improving the quality of life for blood cancer patients and their families for over 75 years [6]
