Summary of OmniAb's OmniUltra Launch Conference Call Company Overview - **Company**: OmniAb, Inc. - **Event**: OmniUltra Launch virtual investor event - **Date**: December 15, 2025 Key Points Industry and Technology - **New Technology**: OmniUltra, a novel platform for discovering ultra-long cDRH3 antibodies and peptides [5][6] - **Unique Features**: OmniUltra is the first transgenic chicken engineered to produce ultra-long cDRH3s, a structural feature typically found in cow antibodies, but with human sequences for therapeutic use [5][6] - **Evolutionary Advantage**: The use of chickens allows for robust immune responses to human targets due to their evolutionary distance from mammals [10][11] Scientific Advancements - **Therapeutic Discovery**: OmniUltra enables the discovery of unique binding fragments called Pico bodies, which can access previously unreachable therapeutic targets [6][7] - **Peptide Therapeutics**: The technology allows for the synthesis of peptides that retain binding activity, providing a new avenue for therapeutic development [12][13] - **Market Growth**: There is a significant increase in the number of new peptides entering clinical trials, indicating a growing interest in peptide therapeutics [17][18] Business Opportunities - **Market Potential**: OmniUltra opens up new licensing opportunities and collaborations, targeting over 130 companies involved in peptide development [18][26] - **Client Engagement**: The technology is expected to attract new partners and revive interest from existing partners, enhancing business development efforts [33][34] - **Revenue Generation**: The platform is anticipated to drive service revenue and increase deal-making diversity [18][19] Competitive Edge - **Biological Intelligence**: The concept that in vivo generated molecules are superior due to natural optimization processes, enhancing specificity and developability [9][10] - **Reduced Immunogenicity**: Smaller peptide structures and stabilized formats are expected to lower immunogenicity risks compared to traditional antibody formats [30][31] Future Outlook - **Partnership Growth**: The launch of OmniUltra is expected to increase the cadence of new partnerships and collaborations in the coming years [32][34] - **Investment in Infrastructure**: OmniAb has made prior investments in facilities and infrastructure, allowing for scalable operations without significant incremental costs [36] Additional Insights - **Scientific Presentations**: OmniUltra was showcased at the Antibody Engineering and Therapeutics Conference, highlighting its innovative capabilities [4][5] - **Confidential Programs**: Three partner programs utilizing OmniUltra technology are currently confidential, but they are generating excitement within the industry [20][21] This summary encapsulates the critical aspects of OmniAb's conference call regarding the launch of their new technology, OmniUltra, and its implications for the industry and the company's future.

PresentationGood afternoon, and welcome to the TriSalus Life Sciences Virtual KOL event. [Operator Instructions] As a reminder, this call is being recorded, and a replay will be made available on the TriSalus website following the conclusion of the event. I'd now like to turn the call over to Mary Szela, Chief Executive Officer and President at TriSalus Life Sciences. Please go ahead, Mary.Mary SzelaCEO, President & Director Thank you, and thank you all for joining today. I'm really excited to kick off this ...

The oncology specialist's targeted therapies could improve thousands of lives.Shares of Immunome (IMNM +15.51%) jumped over 15% on Monday after the biotech company announced positive clinical results for varegacestat, an investigational treatment for patients with progressing desmoid tumors. A destructive diseaseDesmoid tumors can be debilitating and lead to life-threatening organ damage. Each year, 1,000 to 1,650 people are diagnosed with the health condition in the U.S. alone."Desmoid tumors can have a d ...

Financial Data and Key Metrics Changes - Total revenue for Q2 2026 was $15 million, an increase of 11% year-over-year from $13.5 million in Q2 2025, driven by improved conversion of booked work due to a lower level of cancellations [8][9] - Income from operations for the quarter was $185,000, and adjusted EBITDA was approximately $800,000, with the company on track to achieve full-year positive adjusted EBITDA [8][9] - Gross margin improved to 52% compared to 45% in the previous year, supported by flat cost of sales despite increased revenue [9] Business Line Data and Key Metrics Changes - The company reported continued success in radiolabeling and radiopharmaceutical support workflows, which are expected to become a more significant part of the service offering over time [4][5] - Investments in the data platform are ongoing, enhancing its functionality and expanding utility for pharma partners, which is viewed as a critical long-term value driver [5][6] Market Data and Key Metrics Changes - The broader environment shows gradual improvement across pharma and biotech budgets, with customer engagement and opportunity pipeline generation improving relative to the previous year and a half [3] - A recent survey indicated that over a third of biotech executives plan to increase outsourcing next year, suggesting a positive trend for the company's services [15] Company Strategy and Development Direction - The company aims to deliver year-on-year revenue growth, invest in growth levers like data platforms, and maintain fiscal discipline to avoid shareholder dilution [2][3] - Focus remains on execution, maximizing conversion of existing bookings, improving operational efficiency, and advancing capabilities to distinguish the company in the market [3][7] Management's Comments on Operating Environment and Future Outlook - Management expressed cautious optimism for booking momentum in the next calendar year as R&D budgets reset for 2026 [3] - The company is encouraged by improved operational discipline, a strengthening commercial position, and strategic investments in areas with competitive advantages [7][11] Other Important Information - Corelia, a wholly-owned subsidiary focused on target discovery, is making progress in discussions with potential venture capital funding partners, with plans to redirect investment dollars toward accelerating growth in the data business once funding is secured [6] Q&A Session Summary Question: Has there been an uptick in inbound call volume regarding RFPs, and how quickly can the company return to double-digit revenue growth? - Management noted optimism regarding opportunity generation and improvements in the market, with investments in the commercial team positioning the company well for recovery [15] Question: Are sales and marketing investments targeting the data opportunity exclusively? - Management highlighted a recent hire to lead the data business, emphasizing the strategic mindset and domain expertise brought to the team, which will support both data and other services [16] Question: What are the expectations for gross margins moving forward? - Management indicated that gross margins for the service business are expected to remain in the 50%-52% range, with potential fluctuations due to various expenses [19][20] Question: Can the company provide updates on Corelia's drug candidates and potential valuations? - Management refrained from sharing specific details about Corelia but expressed excitement about the data and traction with venture capital partners [22]

Financial Data and Key Metrics Changes - Total revenue for Q2 2026 was $15 million, an increase of 11% year-over-year from $13.5 million, driven by improved conversion of booked work due to a lower level of cancellations [8][9] - Income from operations for the quarter was $185,000, and adjusted EBITDA was approximately $800,000, with the company on track to achieve full-year positive adjusted EBITDA [8][9] - Gross margin improved to 52% compared to 45% last year, supported by flat cost of sales despite increased revenue [9] Business Line Data and Key Metrics Changes - The company reported continued success in radiolabeling and radiopharmaceutical support workflows, which are becoming increasingly significant in oncology drug development [4][5] - Investments in the data platform are ongoing, enhancing its functionality and expanding utility for pharma partners, which is viewed as a critical long-term value driver [5][6] Market Data and Key Metrics Changes - The broader environment shows gradual improvement across pharma and biotech budgets, with customer engagement and opportunity pipeline generation improving relative to the previous year and a half [3] - A recent survey indicated that over a third of biotech executives plan to increase outsourcing next year, suggesting a positive trend for the company's services [15] Company Strategy and Development Direction - The company aims to deliver year-on-year revenue growth, invest in growth levers like data platforms, and maintain fiscal discipline to avoid shareholder dilution [2][3] - Focus remains on execution, maximizing conversion of existing bookings, improving operational efficiency, and advancing capabilities to distinguish the company in the market [3][7] Management's Comments on Operating Environment and Future Outlook - Management expressed cautious optimism for booking momentum in the next calendar year as R&D budgets reset for 2026 [3] - The company is encouraged by improved operational discipline, a strengthening commercial position, and strategic investments in areas with competitive advantages [7][11] Other Important Information - The company ended the quarter with $8.5 million in cash and no debt, maintaining a solid financial position [10] - Corelia, a wholly-owned subsidiary focused on target discovery, is making progress in discussions with potential venture capital funding partners [6] Q&A Session Summary Question: Has there been an uptick in inbound call volume regarding RFPs, and how quickly can the company return to double-digit revenue growth? - Management noted optimism regarding opportunity generation and improvements in the market, with investments in the commercial team positioning the company well for recovery [15] Question: Are sales and marketing investments targeting the data opportunity exclusively? - Management highlighted a recent hire to lead the data business, emphasizing the strategic mindset and domain expertise brought to the team [16] Question: What are the expectations for gross margins moving forward? - Management indicated that gross margins for the service business are expected to remain in the 50%-52% range, with potential fluctuations due to various expenses [19][20] Question: Can the company provide updates on Corelia's drug candidates and potential valuations? - Management refrained from sharing specific details but expressed excitement about the data and traction with VC partners [22]

Financial Data and Key Metrics Changes - Total revenue for Q2 2026 was $15 million, an increase of 11% year-over-year from $13.5 million in Q2 2025, driven by improved conversion of booked work due to a lower level of cancellations [9][10] - Gross margin improved to 52% compared to 45% in the same quarter last year, supported by operational efficiencies [10] - Adjusted EBITDA for the quarter was approximately $800,000, with income from operations at $185,000 [9][10] Business Line Data and Key Metrics Changes - The company reported continued success in radiolabeling and radiopharmaceutical support workflows, which are expected to become increasingly significant in their service offerings [4][5] - Investments in the data platform are ongoing, enhancing its functionality and expanding utility for pharma partners, which is viewed as a critical long-term value driver [5][6] Market Data and Key Metrics Changes - The broader pharma and biotech budgets are gradually improving, with customer engagement and opportunity pipeline generation showing signs of recovery [3] - A recent survey indicated that over a third of biotech executives plan to increase outsourcing next year, reflecting a positive trend in the market [15] Company Strategy and Development Direction - The company aims to deliver year-on-year revenue growth, invest in growth levers like data platforms, and maintain fiscal discipline to achieve positive Adjusted EBITDA without shareholder dilution [2][3] - The focus remains on execution, maximizing conversion of existing bookings, and improving operational efficiency [3][8] Management's Comments on Operating Environment and Future Outlook - Management expressed cautious optimism regarding booking momentum as R&D budgets reset for calendar 2026, indicating a potential for improved performance in the next year [3] - The company is encouraged by its operational discipline and strategic investments in areas where it holds competitive advantages, such as its tumor bank and data platform [7][8] Other Important Information - Corelia, a wholly-owned subsidiary focused on target discovery, is making progress in discussions with potential venture capital partners, with plans to redirect investment dollars toward accelerating growth in the data business once external funding is secured [6] Q&A Session Summary Question: Has there been an uptick in inbound call volume regarding RFPs? - Management noted an improvement in opportunity generation and optimism about the market recovery, with a survey indicating increased outsourcing plans among biotech executives [15] Question: Are sales and marketing investments targeting the data opportunity exclusively? - Management highlighted a recent hire, Dr. Tamir Farid, to lead the data business, emphasizing the strategic and domain expertise he brings to enhance growth opportunities [16] Question: What are the expectations for gross margins moving forward? - Management expects gross margins for the service business to remain in the 50%-52% range, with potential fluctuations due to various expenses, including outsourced lab service costs [19][20] Question: Can you comment on the progress of Corelia's drug candidates? - Management refrained from sharing specific details but expressed excitement about the data and traction with venture capital partners, indicating that more information will be shared in the future [23]

 Toronto, Ontario – TheNewswire - 15 December, 2025 – Helix BioPharma Corp. (TSX: “HBP”, OTC PINK: “HBPCD”, FRANKFURT: “HBP0”) (“Helix” or the “Company”), a clinical-stage oncology company shaping a near future where today’s hard-to-treat cancers are vincible, announces the filing of the Company’s unaudited interim financial statements as of and for the three month period ended October 31, 2025 (the “Financial Statements”), the management’s discussion and analysis (“MD&A”), and the certifications of the Ch ...

All right, folks. Now, each January, investors wait with baiter breath for my next guest to post his 10 predictions. So, let's bring him in.Cross Mark Global, their CEO and CIO, Bob Dah. Uh, Bob, so we we got your 2025 recap as usual. It's pretty good.A lot more checks than X's. Uh, we can't go over the whole thing, but I do want to zero in on the equal weight outperforming because even though that wasn't the case for the year, recently that has been the case. >> We got that so wrong.You're absolutely right ...

OmniUltra Platform Overview - OmniUltra is the first and only transgenic chicken producing antibodies on a human framework with ultralong CDRH3s, similar to those found in cows[24] - Ultralong CDRH3s can reach binding pockets inaccessible to other antibodies, and can be cleaved to create Picobodies, the smallest functional antibody fragment[24] - OmniUltra is engineered for *in vivo* optimization, generating molecules pre-selected for function, affinity, and structural stability, potentially uncovering novel binding domains[27] - The platform leverages a transgenic chicken host to deliver biologically-optimized structured peptides, unlike phage display or other peptide discovery technologies[28] Competitive Advantages and Biological Intelligence - Antibodies generated *in vivo* are naturally optimized for specificity and developability[37] - The immune system in engineered transgenic animals creates optimized antibodies for human therapeutics, termed Biological Intelligence, increasing the efficiency and probability of success in therapeutic antibody discovery[37] - Greater evolutionary distance yields greater immunogenicity and more antibody diversity in chicken platforms[38] Epitope Coverage and Peptide Discovery - OmniUltra chickens are immunoresponsive to a variety of antigen targets[42] - Ultralong CDRH3 IgG clones bind to overlapping and novel epitopes[45] - OmniUltra can identify naturally-optimized peptide sequences that can be chemically synthesized as picobodies and retain antibody-like affinity and specificity to the immunized target[49] Market Opportunities and Expansion - The estimated total available commercial therapeutic market in 2034 is over $1 trillion, including peptides ($332 billion), bi-specifics ($460 billion), CAR-T ($224 billion), and radiopharma ($14 billion)[64] - Expansion into peptides provides an opportunity to drive service revenue and increases the potential audience of new partners by adding >130 peptide companies[66, 68]

Abivax Presents Third Quarter 2025 Financial Results Cash and cash equivalents of EUR 589.7 (as of September 30, 2025) with a cash runway into Q4 2027 PARIS, France, December 15, 2025, 10:05 p.m. CET – Abivax SA (Euronext Paris: FR0012333284 – ABVX / Nasdaq – ABVX) (“Abivax” or the “Company”), a clinical-stage biotechnology company focused on developing therapeutics that harness the body’s natural regulatory mechanisms to stabilize the immune response in patients with chronic inflammatory diseases, announce ...