Core Viewpoint - The article emphasizes the importance of understanding common clinical symptoms in laboratory mice and rats to ensure reliable research data and efficient experimental progress. It introduces a guide that helps researchers quickly identify potential health issues in these animals, thereby reducing misdiagnosis and experimental delays [1]. Summary by Sections Clinical Symptoms Guide - The guide includes over 40 high-frequency symptoms with diagnostic illustrations for quick identification [1]. - It provides emergency handling procedures, such as wound disinfection and determining whether to euthanize an animal [1]. - The guide helps differentiate between environmental and pathological factors affecting the animals' health [1]. Observation Process - A complete animal observation process should encompass various aspects, including external and internal examination, dynamic and static observation, and individual versus overall assessment [6]. - The guide aids in accurately identifying health issues, from weight fluctuations to behavioral changes, with reference images and detailed descriptions [6]. Multi-Dimensional Analysis - The guide encourages a multi-faceted approach to identify the underlying causes of health issues by considering environmental factors, dietary conditions, and genetic backgrounds [7]. - It provides tailored recommendations for addressing health problems, considering the animals' health status, experimental needs, and environmental conditions [7]. Common Symptoms and Management - The article lists various symptoms, their common causes, and recommended handling measures, such as addressing issues like hair loss, weight changes, and abnormal behaviors [9]. - Specific examples include managing weight loss due to dietary insufficiencies or health conditions, and recognizing signs of distress or illness in the animals [9].