以下文章来源于赛业生物订阅号 ，作者小赛 赛业生物订阅号 . 分享生命科学领域的前沿资讯、解读行业动态、讲解实用的学科知识、实验方法和技巧。 国自然 （NSFC） 的资助方向是学科发展的晴雨表。2026年申报在即，洞察热点趋势对于课题设计至关重 要。基于对历年资助项目与前沿发表的综合分析，我们猜测，以下几个热点领域，在新的一年将继续保持高 热度和高竞争力。 ➢ 核心机制类： 免疫调控 （巨噬细胞极化、中性粒细胞、T细胞耗竭） 、线粒体功能与稳态、新型细胞死 亡 （铁死亡、焦亡） 、代谢重编程 （糖酵解、乳酸化） 、蛋白质翻译后修饰 （泛素化、SUMO化、组蛋 白修饰） ； ➢前沿交叉类： 表观转录组学 （RNA修饰，如m6A、m7G） 、细胞间通讯 （外泌体） 、宿 主-微生物互作 （肠道菌群） 、干细胞与再生医学； ➢关键技术类： 单细胞与空间多组学、类器官与疾病模型、人工智能/机器学习驱动的靶点发现与数据分析 这些方向并非孤立存在，例如铁死亡不仅是一种程序性细胞死亡机制，更与免疫代谢、蛋白质修饰网络和 RNA表观调控紧密相连；外泌体则作为载体，跨界调控着肿瘤免疫与神经疾病中的细胞命运……因此， 从单 一热 ...

Core Insights - Two Japanese research teams, including Nobel Prize winner Shimon Sakaguchi, have developed an efficient method to convert pathogenic T cells into regulatory T cells, showing promise for treating autoimmune diseases in mouse models [1][2] Group 1: Research Methodology - The Osaka University team established an innovative strategy to generate antigen-specific regulatory T cells from existing T cell resources in the human body, successfully activating effector T cells and promoting the expression of the key transcription factor Foxp3 [2] - The method demonstrated broad applicability across various human and mouse memory and effector T cells, effectively controlling autoimmune responses in inflammatory bowel disease and graft-versus-host disease [2] Group 2: Clinical Applications - Keio University applied the same technology to a mouse model of pemphigus vulgaris, a disease driven by autoreactive CD4+ T cells, successfully converting pathogenic T cells into stable regulatory T cells [2] - The converted regulatory T cells migrated to skin-associated lymph nodes, effectively suppressing the activation of pathogenic T cells and the production of autoantibodies, leading to alleviation of skin lesions [2]

Core Insights - The recent Nobel Prize in Physiology or Medicine has reignited global interest in immunology, particularly focusing on immune tolerance and regulation, which aligns with the scientific core of the company's product CKBA [1][2][3] Company Overview - TianKang is recognized as a leading Chinese innovative pharmaceutical company, making significant strides in the immunotherapy sector with its core product CKBA, which indicates a forward-looking approach in precision medicine [1][4] - The company has shifted from a traditional sales-driven model to an integrated "research-production-sales" model, with a cumulative R&D investment of nearly 320 million yuan from 2023 to 2024, maintaining an R&D intensity exceeding 20%, significantly higher than the industry average [4] Product Development - CKBA is the world's first innovative small molecule targeting T cell fatty acid metabolism pathways, specifically binding to fatty acid metabolism enzymes ACC1/MFE-2, allowing for precise regulation of CD8+ cytotoxic T lymphocytes (CTLs) [3][5] - The clinical advancement of CKBA has been rapid, with Phase II clinical trials for vitiligo showing significant efficacy and safety advantages, and plans for Phase III trials are underway [4][5] Market Positioning - The immunotherapy market is growing at an annual rate of over 10%, but it is highly competitive and saturated. CKBA's targeted immune regulation offers a differentiated advantage, potentially creating a new market space [5] - The product's development reflects a broader industry shift from "immune suppression" to "immune reconstruction," resonating with the foundational research recognized by the Nobel Prize [5]

Core Viewpoint - The company TianKang (301263) clarified that CKBA is not the specific research outcome of the 2025 Nobel Prize in Medicine, but it focuses on the core areas of immunological "immune tolerance" and "immune regulation" [1] Summary by Relevant Categories - **Product Development** - CKBA is not a broad immunosuppressant but offers a more targeted approach compared to traditional immunosuppressants, providing a new strategy for restoring self-immune balance [1]

Core Viewpoint - The article discusses the groundbreaking discoveries by Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi, who were awarded the 2025 Nobel Prize in Physiology or Medicine for their work on regulatory T cells (Treg cells) and their role in peripheral immune tolerance, significantly enhancing the understanding of immune regulation and its implications for autoimmune diseases and cancer [3][11][19]. Group 1: Key Discoveries - The researchers identified and defined CD4+ CD25+ FOXP3+ regulatory T cells (Treg cells) and their critical role in controlling self-reactive responses, leading to the establishment of a new field of study in immune tolerance [3][11][19]. - Shimon Sakaguchi made the first key discovery in 1995, demonstrating that immune tolerance is more complex than previously thought, revealing a previously unknown T cell type that protects against autoimmune diseases [11][14]. - In 2001, Brunkow and Ramsdell discovered a gene mutation in specific mouse strains that made them prone to autoimmune diseases, naming the gene Foxp3, which is also linked to a severe autoimmune disease in humans known as IPEX syndrome [14][18]. Group 2: Implications and Future Directions - The findings of these researchers have opened new avenues in the treatment of cancer and autoimmune diseases, with potential to improve organ transplant success rates, as therapies based on their discoveries are currently in clinical trials [19][20]. - There are over 200 clinical trials involving Treg cells aimed at treating common diseases such as asthma, inflammatory bowel disease, and skin-related conditions, or improving organ transplant outcomes [23]. - The achievements of Brunkow, Ramsdell, and Sakaguchi highlight the importance of scientific perseverance and the integration of clinical observations with basic research, paving the way for enhanced understanding and therapeutic applications of Treg cells [24].