Core Viewpoint - The article emphasizes the harmful impact of sugary drinks on the progression of colorectal cancer (CRC), highlighting a significant correlation between the consumption of these beverages and the increased incidence and mortality rates of CRC among younger populations [2][6][9]. Group 1: Sugary Drinks and Colorectal Cancer - Sugary drinks, defined as liquids containing added sugars like sucrose and high-fructose corn syrup, have seen a global increase in consumption since the 1980s, closely linked to metabolic diseases such as obesity and diabetes [2][6]. - A study published by researchers at the MD Anderson Cancer Center indicates that fructose and glucose from sugary drinks enhance CRC metastasis through the activation of the enzyme sorbitol dehydrogenase (SORD) [3][9]. - Epidemiological studies have shown that the intake of sugary drinks is associated with a doubling of the risk of developing CRC in younger individuals [6]. Group 2: Mechanisms of Action - The latest research reveals that a combination of glucose and fructose enhances the migratory and metastatic potential of CRC cells compared to glucose alone, reflecting the composition of sugary drinks [7]. - The mechanism involves the activation of the polyol pathway, which increases the NAD⁺/NADH ratio, thereby accelerating glycolytic activity and promoting the activation of the mevalonate pathway, ultimately facilitating cancer cell migration and metastasis [7][9]. Group 3: Implications for Treatment - The findings suggest potential dietary interventions and treatment strategies to inhibit the metastasis of CRC in patients, highlighting the need for awareness regarding the consumption of sugary drinks [9].