Core Viewpoint - OriCell, a subsidiary of Saiye, focuses on cell biology and stem cell technology services, emphasizing the importance of mesenchymal stem cells (MSC) in regenerative medicine and their growing application in clinical trials [2][10]. Group 1: MSC Research and Development - MSCs have unique differentiation potential and immune regulation capabilities, making them a key focus in regenerative medicine [2]. - The National Medical Products Administration (NMPA) has approved nearly 200 clinical trial applications for stem cell products, with the first MSC therapy, "Aimi Maitosai Injection," set to launch in early 2025 for treating hormone-refractory acute graft-versus-host disease [2]. - The application boundaries of MSCs are expanding, serving as a crucial bridge between basic research and clinical translation [2]. Group 2: Research Support and Resources - OriCell has compiled a research guide titled "Mesenchymal Stem Cells: Cultivation and Tri-lineage Induction," aimed at both newcomers and experienced research teams to provide practical technical support [3]. - The guide offers a systematic framework of MSC knowledge, detailing definitions, characteristics from different sources, and biological functions to help establish foundational understanding [5]. - It includes standardized operational processes, breaking down key procedures such as cell passage digestion time, cryopreservation points, and recovery plating density, along with tri-lineage induction steps and identification methods [5]. Group 3: Practical Solutions and Optimization - The guide provides practical solutions to common experimental challenges, analyzing factors like serum quality and culture temperature, and offering validated optimization strategies to avoid typical pitfalls in experiments [5]. - OriCell aims to enhance the confidence in MSC cultivation and induction processes, supporting researchers in overcoming experimental difficulties [7].

编辑丨王多鱼 排版丨水成文 上世纪四十年代，英国学者 Conrad Waddington 提出了著名的 "发 育景观 " 概念：细胞的命运就像是一个小球在山谷间滚动，随着发育的推进，小球会经过不 同的分叉，最终落入各自的谷底，成为神经元、肌肉细胞或免疫细胞 等 。这一生动的比喻奠定了我们理解细胞命运的基本框架 。 今天，我们已经知道，细胞的命运并非单向不可逆转。干细胞研究和重编程实验表明，代表细胞的小球并不是只能顺着山谷 "滚"下去，它完全可能被"推回"到高 处，甚至转入另一条全新的轨迹。逆分化和转分化的发现，揭示了细胞命运的可塑性。这让一个新的问题浮现—— 如果细胞的路径可以被改变，我们能否真正描 绘并操控这张命运地图？ 这正是细胞生物学 领域 长期以来追寻的 "圣杯问题" 。如果能够解决这一难题，我们将不仅能更深刻地理解发育与疾病的规律，更可能对医学和生命科学带来深 远的影响。我们或许能够在再生医学中实现受损组织的精准修复；在肿瘤研究中找到阻止恶性转化的关键节点，从而更高效地开发个性化疗法；在药物研发中预 测细胞对干预措施的反应路径，优化候选药物筛选过程，甚至揭示隐藏的副作用机制。 但遗憾的是， 传统方法 ...