Industry Overview - The fourth-quarter 2025 reporting season for the Medical sector is nearing its final stretch, with only a few pharma and biotech companies left to report [1] - As of February 11, 73.3% of companies in the Medical sector, representing 91% of the sector's market capitalization, reported quarterly earnings, with 86.4% exceeding both earnings and sales estimates [2][10] - Overall, fourth-quarter earnings in the medical sector are expected to decrease by 0.6%, while sales are projected to rise by 10.4% compared to the previous year [4] Company Performance Johnson & Johnson - Reported strong fourth-quarter results, beating estimates for both earnings and sales [3] Novartis - Beat earnings estimates but faced revenue pressure due to generic competition for key drugs like Entresto and Promacta [3] Bristol Myers Squibb - Beat both earnings and sales estimates and issued encouraging guidance [3] Gilead Sciences - Earnings exceeded both top and bottom lines, supported by higher sales of HIV and Liver Diseases drugs [3] Bausch Health - Mixed performance with two earnings beats and two misses in the last four quarters, delivering a four-quarter average negative surprise of 6.26% [5] - Scheduled to report on February 18, with an Earnings ESP of -8.84% and a Zacks Rank 3 [7] Amicus Therapeutics - Disappointing earnings track record with three misses and one beat in the last four quarters, averaging a negative surprise of 20.21% [8] - Set to be acquired by BioMarin, with its lead drug Galafold showing solid uptake [9] BioMarin Pharmaceutical - Impressive track record, beating earnings estimates in each of the last four quarters with an average surprise of 66.51% [11] - Scheduled to report with an Earnings ESP of -3.23% and a Zacks Rank 3, driven by strong demand for its dwarfism drug Voxzogo [12] Insmed - Poor earnings track record with four consecutive misses, averaging a negative surprise of 20.64% [13] - Scheduled to report on February 19, with an Earnings ESP of +7.01% and a Zacks Rank 3 [14] - Lead drug Arikayce gaining traction, with a new drug approval marking a significant milestone [15] Madrigal Pharmaceuticals - Missed earnings expectations in three of the last four quarters, with an average negative surprise of 17.17% [16] - Scheduled to report on February 19, with an Earnings ESP of -852.37% and a Zacks Rank 4 [16][17]

Summary of China Pharma and Biotech Conference Call Industry Overview - **Sector Outlook**: The China Pharma and Biotech sector is experiencing a positive outlook with valuations returning to a more rational range compared to mid-2025. Most stocks have seen a decline of 20-30%, and major healthcare indices are below 2023 post-COVID reopening levels, providing a solid base for growth in 2026 [1][10][11]. - **Growth Drivers**: Accelerated growth and quality improvement in the sector are anticipated, driven by the unique advantages of Chinese drugmakers that support globalization and sector re-rating trends [1][10]. Key Insights on China Biopharma - **R&D Efficiency**: China's early R&D model has matured, with clinical trials costing 60-70% less than in the U.S. Preclinical research averages 1.5 years, and Phase 1 trials take less than 2 years, significantly faster than global standards [2]. - **Global Pipeline Contribution**: China's share of the global biopharma pipeline has increased to 43% in 2025, up from 38% in 2024. However, the percentage of First-in-Class (FIC) drugs remains lower than in developed markets (17% vs. 37%) [2]. - **Out-licensing Trends**: The trend of outbound deals is expected to continue, with innovative models like platform deals and co-development agreements emerging. These deals are seen as avenues for revenue maximization, although they may not impact stock prices as significantly as in 2025 [2][13]. Stock-Specific Catalysts for 2026 - **Oncology Developments**: A significant number of trials (20+) in Non-Small Cell Lung Cancer (NSCLC) are expected to report data, with key players including Kelun, Innovent, and Akeso. New modalities such as multispecific antibodies and ADCs are also anticipated to provide proof of concept data [3]. - **GLP-1 Drugs**: HRS-9531 (Hengrui) and TG103 (CSPC) have submitted New Drug Applications (NDA) in the second half of 2025, with expected approvals in late 2026 or 2027 [3]. Top Stock Picks - **Innovent**: Anticipated strong sales growth for mazdutide and updates on IBI363 trials across various indications [4]. - **Kelun**: Expected to report results from its first global Phase 3 trial and domestic sales growth of approximately 40% [4]. - **Hansoh & Hengrui**: Projected recurring license income to contribute 10-15% of revenue, with net income growth of 20-30% CAGR from 2024 to 2027 [4]. Investment Ratings - **Outperform Ratings**: Hansoh, Kelun-Biotech, Innovent, and Jiangsu Hengrui are rated as outperform [6]. - **Market-Perform Ratings**: Akeso, BeOne Medicines (BeiGene), Sino Biopharm, Zai Lab, and CSPC are rated as market-perform [6]. Financial Projections - **Stock Performance**: The report includes a detailed table of stock ratings, target prices, and financial projections for various companies, indicating significant upside potential for selected stocks [5][9]. Additional Insights - **Market Dynamics**: The sector has transitioned from exuberance to equilibrium, with a notable correction in stock prices since October 2025, following a period of rapid growth [10][11]. - **Approval Trends**: The number of innovative drug approvals by the National Medical Products Administration (NMPA) has accelerated, with 69 approvals in 2025, while the FDA remains receptive to Chinese drug candidates [33]. This summary encapsulates the key points from the conference call, highlighting the positive outlook for the China Pharma and Biotech sector, the efficiency of R&D processes, stock-specific catalysts, and investment recommendations.

Core Viewpoint - The healthcare sector is identified as a potential investment opportunity for 2026, with expectations of a strong recovery and growth, particularly in pharmaceuticals and biotechnology [2][3][5]. Sector Performance - Healthcare has recently shifted from being one of the worst-performing sectors to outperforming financials, with the Health Care Select Sector SPDR ETF (XLV) up approximately 10% year-to-date, compared to a 6%+ gain for the Financial Select Sector SPDR (XLF) [4]. Investment Strategy - Investors are rotating out of technology stocks and seeking growth opportunities in sectors with lower valuations, with healthcare being highlighted as particularly attractive due to its low valuation compared to the S&P 500 [5]. - The healthcare sector is expected to benefit from a "catch-up trade" and valuation rotation, with a bullish outlook for 2025 and beyond, especially in midterm election years like 2026 [6]. Market Sentiment - Despite initial concerns regarding inflation and AI monetization, these risks have not materialized, leading to a more favorable outlook for the healthcare sector [6].

Company Overview - Eli Lilly and Company is represented by Lucas Montarce, CFO, and Mike Czapar, SVP of Investor Relations, during the BofA Securities 2025 Health Care Conference [1][2]. Industry Context - The discussion includes insights on drug pricing policies, particularly referencing the potential impact of political actions, such as those from former President Trump, on the pharmaceutical industry [3]. Financial Leadership - Lucas Montarce has been with Eli Lilly since 2021 and has held the CFO position since September 2024, indicating a strong leadership presence in both U.S. and international roles [1].