Core Viewpoint - The article highlights the concerns regarding the accuracy of at-home flu antigen testing kits, particularly in the context of rising flu cases during the winter season, emphasizing the limitations of these tests compared to more reliable methods like nucleic acid testing [1][2][3]. Group 1: Accuracy of Antigen Tests - Antigen tests for flu (H1N1 and H3N2) are generally less sensitive and specific than nucleic acid tests, which are considered the "gold standard" for respiratory infectious disease detection [2][3]. - The optimal time for antigen testing is within 1-3 days post-infection, with the highest positive rate typically occurring on the second day of illness [2][3]. - Factors affecting the accuracy of antigen tests include the patient's immune status, virus strain, and the timing and quality of sample collection [2][3]. Group 2: Self-Testing and Risks - Self-testing for flu using antigen kits can lead to false negatives, as seen in the case of a mother who tested negative multiple times before receiving a positive result through nucleic acid testing [1][3]. - Proper sample collection is crucial, and even trained professionals can struggle with accurate sampling in non-clinical settings [3][4]. - The article stresses the importance of following guidelines for using antigen tests, including selecting approved products and adhering to operational protocols [4]. Group 3: Treatment and Medical Guidance - Positive results from self-testing do not necessarily require immediate antiviral medication, especially for healthy adults, as flu is often self-limiting [6]. - High-risk groups, including young children, the elderly, and those with chronic health conditions, should seek medical attention promptly if they test positive [6][7]. - Caution is advised when self-administering antiviral medications, as they may interact with other prescribed treatments [7]. Group 4: Public Health Recommendations - The article discusses the current flu season's characteristics, noting a predominance of the H3N2 strain and the potential for increased transmission during large public gatherings [8]. - Recommendations for public health include wearing high-quality masks in crowded places, maintaining hand hygiene, and getting vaccinated against the flu [8].