就在今年5月，患者腹壁脓腔合并的肉芽肿已经突破了皮肤，再次手术也无法去除感染灶。绝望之 际，朱同玉教授噬菌体团队通过精准配型，找到裂解性噬菌体。 记者 顾泳 抗生素耐药已成为全球临床医学一大难题。数据统计，全球每年抗生素耐药相关死亡病例达400万 人，直接死亡病例达130万人。如何应对棘手的抗生素耐药？19日起在复旦大学附属中山医院召开的中 国生物工程学会噬菌体大会暨第八届中国噬菌体治疗大会传出消息，噬菌体疗法或成破解抗生素耐药的 全新突破口。 复旦大学医学院副院长朱同玉教授为记者介绍临床案例。56岁男性肾移植术后七年，两年前因移植 肾周和腹壁感染反复多次入院就医，髂窝移植肾周穿刺引流和腹壁脓肿分泌物培养均提示大肠埃希菌 （多重耐药），予以多种抗菌药物治疗后，细菌难以清除。患者前后进行了三次手术切除，效果也不 佳。 噬菌体治疗像剥洋葱一样，一步步摧毁患者体内的感染病灶。在经过多轮噬菌体局部治疗后，患者 伤口愈合，伤口下的感染灶已明显缩小好转。目前患者一般情况稳定，无需使用抗生素，体温正常，各 项感染指标持续好转中。 什么是噬菌体？朱同玉解释：生态环境可谓"一物降一物"，噬菌体是侵袭细菌的病毒，也是赋予宿 主菌 ...

Core Insights - The article discusses the potential of phage therapy as a solution to the challenges posed by multi-drug resistant bacteria, which traditional antibiotics struggle to combat [1][2] - Phage therapy offers targeted action with minimal side effects and a lower likelihood of inducing resistance, addressing critical clinical treatment challenges [1] Group 1: Phage Therapy Overview - Phage therapy is a treatment method that utilizes bacteriophages, viruses that specifically infect bacteria, to treat bacterial infections [1] - Unlike traditional antibiotics, phages can precisely identify and lyse specific bacteria while maintaining the balance of normal human microbiota [1] Group 2: Historical Context and Case Study - Phage therapy was previously used in the 1920s and 1930s for various infections but fell out of favor with the advent of antibiotics [2] - A case study is presented involving an 18-year-old patient with cystic fibrosis who was infected with carbapenem-resistant Pseudomonas aeruginosa, where traditional antibiotics were ineffective [2] - The patient underwent a 42-day treatment using phage therapy, resulting in significant health improvements, including normalization of temperature and weight gain of 3 kilograms [2] Group 3: Future Directions - Experts are exploring the potential of gene editing technologies to modify phages, which may lead to personalized treatment options in the future [2]