Core Insights - The article discusses a significant research paper published in Cell Genomics, focusing on the multi-omic underpinnings of heterogeneous aging across multiple organ systems [4][6]. - The research aims to shift the paradigm of age-related disease management from a "divide and conquer" approach to a "unified prevention" strategy by understanding the molecular mechanisms of aging [7][9]. Research Objectives - The study aims to clarify the genetic associations between organ-specific aging and blood-based epigenetic aging, revealing phenotypic clusters related to heterogeneous aging across multiple organ systems [7]. - It seeks to identify candidate gene drug targets associated with these heterogeneous aging processes and evaluate opportunities for repurposing existing drugs [7]. - The research intends to uncover downstream proteomic and metabolomic effects driven by organ-specific and blood-based epigenetic aging, identifying detectable biomarkers [7]. - The study integrates findings to map the interaction networks of heterogeneous aging across multiple organ systems and their potential cross-layer molecular regulatory mechanisms [7][10]. Key Findings - The research team developed a framework based on R/Shiny, accessible online, providing a comprehensive multi-omic molecular map of heterogeneous aging [9]. - The study advances the understanding of aging heterogeneity, offering insights for precision medical strategies aimed at delaying organ-specific aging and preventing or treating related chronic diseases [9][10]. - Heterogeneous aging phenotypic clusters exhibit distinct biological characteristics, and genomic approaches have identified priority drug targets for addressing this aging heterogeneity [10].